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排序方式: 共有235条查询结果,搜索用时 298 毫秒
1.
N Shinoura T Kondo I Muraoka Y Tsukamoto M Yoshioka H Miyazawa 《No shinkei geka. Neurological surgery》1990,18(6):557-561
Two cases of sacrococcygeal teratoma in female infants are reported. Case 1. A newborn baby with a hemispheric mass on her hip underwent surgery 3 days after birth and the lesion proved to be an immature teratoma. The serum AFP level was very high but became normal one month after the operation. The child also had agenesis of the corpus callosum and arachnoid cysts in right middle fossa. She died after developing shunt infection. Case 2. A newborn baby with a mature teratoma was operated on the day following birth. The tumor was subtotally removed, and there has been no recurrence after 6 months. Sacrococcygeal teratoma in female infants is often associated with agenesis of the corpus callosum and arachnoid cysts. They tend to develop almost at the same time as the teratoma. It is often difficult to determine whether the infant should be treated by chemotherapy or not if the teratoma is immature, especially when it has been totally removed, the serum AFP is normal, and the tumor is pathologically of a low grade. 相似文献
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Preclinical studies in animal models and human clinical trials have evaluated the safety and efficacy of adenoviral vectors for cancer gene therapy. These studies have indicated that gene delivery via adenoviral vectors, including p53 gene therapy, represents a promising therapeutic modality for many types of human cancers. This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis-related genes, including Fas ligand, Fas, FADD, caspase-8, p53, p33ING1, p73alpha, Bax, Apaf-1, caspase-9, IkappaBdN, caspase-3, Bcl-2, and Bcl-X(L). We conclude that adenoviral vector-mediated delivery of apoptosis-related genes other than p53 is a potentially useful gene therapy approach toward the treatment of human brain tumors. 相似文献
4.
Nakamura K Funabashi N Miyauchi H Aminaka M Uehara M Ueda M Murayama T Hori Y Nakayama T Daimon M Kuroda N Kobayashi Y Komuro I 《International journal of cardiology》2008,127(3):437-441
We report the case of a 38-year-old Asian man with a pericardial hemangioma on the left main coronary artery. The patient presented initially at our hospital after cardiopulmonary resuscitation following an episode of ventricular fibrillation (VF). Because of spontaneous coved-type ST segment elevation on the higher intercostal space V1 to V2 in a 12-lead electrocardiogram, documented VF in the absence of structural heart disease, and a family history of sudden death, he was diagnosed with Brugada syndrome. Transesophageal echocardiography showed a smooth-surfaced mass with well-demarcated borders, directly above the left main coronary artery. Computed tomography confirmed the presence of the mass, which showed no enhancement at early phase, but did demonstrate homogenous enhancement at delay phase by contrast material. There were no findings from either the nuclear medicine or the tumor marker investigations which indicated that the mass located just above the main coronary arteries was malignant. Therefore, taken together, these findings suggested that the tumor might be a pericardial hemangioma. The relationship between the location of the hemangioma just above the left main coronary artery and the occurrence of VF was not clear, i.e. whether the presence of the hemangioma caused the stimulation of the left main coronary artery and as a result, led to the spasm of the left main coronary artery and the occurrence of VF. Furthermore, as the tumor did not extend into any of the adjacent structures, such as the coronary arteries or the right ventricular outflow tract, surgical resection was not performed; instead, the patient received a dual chamber implantable cardioverter-defibrillator. 相似文献
5.
Kohki Nakamura MD PhD Takehito Sasaki MD Yutaka Take MD PhD Kentaro Minami MD Mitsuho Inoue MD Chisa Asahina MD Wataru Sasaki MD Shohei Kishi MD Shingo Yoshimura MD Yoshinori Okazaki MD Hiroyuki Motoda MD PhD Katsura Niijima MD PhD Yuko Miki MD PhD Koji Goto MD PhD Kenichi Kaseno MD PhD Eiji Yamashita MD PhD Keiko Koyama MD PhD Nobusada Funabashi MD PhD Shigeto Naito MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):16-26
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H. Sadamori T. Yagi S. Shinoura Y. Umeda R. Yoshida D. Satoh D. Nobuoka M. Utsumi T. Fujiwara 《The British journal of surgery》2013,100(1):122-129
Background:
Bile leakage, and organ and/or space surgical‐site infection (SSI) are common causes of major morbidity after partial hepatectomy for hepatocellular carcinoma (HCC). The purpose of this study was to analyse risk factors for major morbidity and to explore strategies for its reduction after partial hepatectomy for HCC.Methods:
Risk factors for bile leakage and organ/space SSI were analysed in patients who underwent partial hepatectomy for HCC between 2001 and 2010. The causes, management and outcomes of intractable bile leakage requiring endoscopic therapy or percutaneous transhepatic biliary drainage were analysed. In addition, causative bacteria, outcomes and characteristics of organ/space SSI were investigated. Risk factors were identified using multivariable analysis.Results:
Some 359 patients were included in the analysis. The prevalence of bile leakage and organ/space SSI was 12·8 and 8·6 per cent respectively. Repeat hepatectomy and an operating time of at least 300 min were identified as independent risk factors for bile leakage. The main causes of intractable bile leakage were latent strictures of the biliary system caused by previous treatments for HCC and intraoperative injury of the hepatic duct during repeat hepatectomy. Independent risk factors for organ/space SSI were repeat hepatectomy and bile leakage. Methicillin‐resistant Staphylococcus aureus was detected more frequently in organ/space SSI after repeat hepatectomy than after initial partial hepatectomy.Conclusion:
Repeat hepatectomy and prolonged surgery were identified as risk factors for bile leakage after liver resection for HCC. Bile leakage and repeat hepatectomy increased the risk of organ/space SSI. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. 相似文献8.
Hiroshi Sadamori Takahito Yagi Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Daisuke Satoh Daisuke Nobuoka Masashi Utsumi Toshiyoshi Fujiwara 《Journal of gastrointestinal surgery》2013,17(2):403-407
Introduction
The management of a large splenorenal shunt is important because it affects recipient outcome, particularly in living donor liver transplantation.Methods
To manage large splenorenal shunts in living donor liver transplantation, we diverted superior mesenteric vein and splenic portal vein blood flow by ligation at the root of the splenic portal vein.Result
This procedure was applied for five patients in whom superior mesenteric vein blood flow had been completely stolen by a splenorenal shunt preoperatively. Postoperative course was excellent in all cases.Conclusion
This technique completely prevents morbidity related to large splenorenal shunts after living donor liver transplantation. 相似文献9.
Tadashi Shiohama Katsunori Fujii Ryota Ebata Nobusada Funabashi Goro Matsumiya Yuko Kazato Saito Fumie Takechi Yoko Yonemori Yukio Nakatani Naoki Shimojo 《Pediatrics international》2016,58(6):487-490
Williams syndrome is a contiguous gene deletion syndrome resulting from a heterozygous deletion on chromosome 7q11.23, and is characterized by distinctive facial features and supravalvular aortic stenosis (SVAS). This syndrome rarely presents unpredictable cardiac death, and yet, as illustrated in the present case, it is still not possible to predict it, even on close monitoring. We herein describe the case of a 6‐year‐old Japanese girl with Williams syndrome, who had sudden cardiac collapse due to cardiac infarction after pharyngitis. Cardiac failure followed a critical course that did not respond to catecholamine support or heart rest with extracardiac mechanical support. Although marked coronary stenosis was not present, the left coronary cusp abnormally adhered to the aortic wall, which may synergistically cause coronary ostium occlusion with SVAS. Altered hemodynamic state, even that caused by the common cold, may lead to critical myocardial events in Williams syndrome with SVAS. 相似文献
10.
Masae Uehara Nobusada Funabashi Hiroyuki Takaoka Koya Ozawa Shunichi Kushida Junji Kanda Yoshihide Fujimoto Yoshio Kobayashi 《International journal of cardiology》2014