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排序方式: 共有73条查询结果,搜索用时 77 毫秒
1.
Chukwuedozie K. Ajaero Clifford O. Odimegwu Vesper Chisumpa Nkechi Obisie-Nmehielle 《International Journal of Mental Health Promotion, The》2017,19(4):189-201
Mental health status is fundamental to overall health and well-being but most studies on the relationship between migration and mental health status deal with international migration and neglects internal migration. Therefore, this study compares the mental health status of internal migrants with that of non-migrants; and also appraises the socio-demographic factors associated with mental health status in South Africa. Data were from the National Income Dynamics Study (NIDS), waves 3 (2012), and 4 (2014) of South Africa. Univariate analysis was used to describe the study population, bivariate analysis was use to explain the mental health status of the population, and binary logistic regression was used analyze the socio-demographic factors associated with mental health status. The study found significant differences in the mental health status of migrants and non-migrants across the waves of NIDS used for this study. While, the migrants had better mental health status in 2012, the non-migrants had better mental health status in 2014. In addition, factors significantly associated with mental health status in 2012, were marital status, income, and province of residence. On the other hand, only race, and province of residence were significantly associated with mental health status in 2014. 相似文献
2.
Kingsley Iyoko Iseko Solomon M. Awoyemi Meraiyebu Aminyene Essien Akafa Tensaba Nkechi Gift Inyang Josephine Bosede Iseko Friday Olah 《Radiology Case Reports》2022,17(2):392
Primary intraosseous synovial sarcoma is an extremely rare malignancy that occurs primarily in young adults. We present a case of a primary intraosseous synovial sarcoma of the right distal ulna in a 19-year-old female. It has a propensity to mimic other radiologic and pathologic diagnosis. Histopathology after a surgical excisional biopsy with a wide margin plus adjunct radio and chemotherapy are necessary to improve prognosis. 相似文献
3.
Khare RK Settimi PD Mba NI Wechsler DS Bratton SL Williams DM 《The Annals of thoracic surgery》2005,80(2):731-733
We present an 11-year-old girl with acute myelogenous leukemia and hemoptysis from abscess erosion into the descending thoracic aorta. We report a pediatric case of an aortobronchial fistula treated with an aortic endograft and discuss the technical limitations and potential complications of this procedure. 相似文献
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Amos S Akah PA Enwerem N Chindo BA Hussaini IM Wambebe C Gamaniel K 《Pharmacology, biochemistry, and behavior》2004,77(4):751-759
The effects of the ethanol extract of Pavetta crassipes on the central nervous system (CNS) and on actions of some selected centrally acting drugs were studied in mice and rats. These studies were carried out using the spontaneous motor activity (SMA), amphetamine-induced hyperactivity and stereotyped behaviour, pentobarbital-induced hypnosis and exploratory activity, apomorphine-induced climbing and haloperidol-induced catalepsy in rats. The results demonstrated that the extract of P. crassipes dose-dependently decreased SMA in mice and attenuated amphetamine-induced hyperactivity and the different episodes of stereotypic behavioural patterns induced by amphetamine. In addition, the extract decreased the number of head dips in the exploratory activity test and potentiated pentobarbital-induced sleeping time in rats. Furthermore, the extract inhibited apomorphine-induced climbing in mice and potentiated haloperidol-induced catalepsy in rats. Our results suggest that the extract of P. crassipes contains biologically active substance(s) that might be acting centrally through the inhibition of dopaminergic pathway or a system linked to this pathway to mediate the observed pharmacological effects. 相似文献
6.
Fleishaker JC McEnroe JD Azie NE Francom SF Carel BJ 《Clinical pharmacology and therapeutics》2002,71(3):169-175
OBJECTIVE: Our objective was to investigate the cardiovascular effects of almotriptan, a 5-hydroxytryptamine 1B/1D agonist, in treated patients with hypertension. METHODS: Twenty patients with hypertension controlled by medication received the following treatments in a randomized, double-blind, crossover design: one placebo tablet, one 12.5-mg almotriptan tablet, and one 25-mg almotriptan tablet. Serial blood samples for analysis of almotriptan were obtained through 24 hours after administration. Serial measurements of supine blood pressure, 12-lead electrocardiograms, and Holter electrocardiographic recordings were also obtained. Plasma almotriptan concentrations were measured with use of a liquid chromatography-tandem mass spectrometry assay. Differences between treatments in pharmacokinetic parameters were assessed with an ANOVA model appropriate for a crossover design. Blood pressure measures and QTc intervals were analyzed for treatment effects with use of a similar model. Analyses were performed on weighted mean and maximal changes from baseline for intervals from 0 to 4 and 0 to 12 hours after administration. RESULTS: Significant linear effects of dose were observed for the maximal change in diastolic blood pressure and for the maximal and mean changes in systolic blood pressure. These effects were consistent for both the 4- and 12-hour periods after dosing. Mean changes from baseline during the interval from 0 to 4 hours were 1.59 +/- 3.88, 1.85 +/- 5.94, and 4.84 +/- 5.99 mm Hg for systolic pressure and 1.38 +/- 6.95, 6.25 +/- 9.54, and 11.0 +/- 10.6 mm Hg for diastolic pressure for placebo, 12.5 mg almotriptan, and 25 mg almotriptan, respectively. No instances of hypertensive crisis were observed. No QTc interval prolongation was observed. CONCLUSIONS: Almotriptan has effects on blood pressure in subjects with controlled hypertension that are consistent with those of other members of the pharmalogic class. 相似文献
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The interaction between almotriptan, a 5-HT1B/1D agonist, and the potent CYP3A4 inhibitor ketoconazole was examined in 16 healthy volunteers. Subjects received (A) 12.5 mg almotriptan orally on Day 2 of a 3-day regimen of 400 mg ketoconazole once daily and (B) 12.5 mg almotriptan in a crossover design. Plasma and urine concentrations of almotriptan were measured by HPLC. Treatment effects on almotriptan pharmacokinetics were assessed by analysis of variance. Ketoconazole coadministration increased mean almotriptan AUC and Cmax from 312 to 490 ng h/mL and 52.6 to 84.5 ng/mL, respectively. Mean oral clearance was decreased from 40.7 to 26.2 L/h by ketoconazole, with an accompanying increase in the fraction of almotriptan excreted unchanged in the urine (40.6% to 53.3%) and a decrease in renal clearance (16.4 to 13.8 L/h). These effects were statistically significant. The effects of ketoconazole on almotriptan clearance were consistent with inhibition of the CYP3A4-mediated metabolism and a slight effect on the active tubular secretion of almotriptan. 相似文献
8.
Faustina Nkechi Osuji Charles Chinedum Onyenekwe Martins Ifeanyichukwu Joseph Ebere Ahaneku Micheal Ezeani Ifeoma Pricilla Ezeugwunne 《Asian Pacific journal of tropical medicine》2012,5(11):841-847
ObjectiveTo determine the antioxidant status of HIV and malaria co-infected participants.MethodsBlood samples collected from the 193 randomly recruited participants were used for HIV screening, Plasmodium falciparum antigen screening, malaria parasite density count, CD4+ T cell count, glutathione reductase, glutathione peroxidase and total antioxidant status measurement. Standard laboratory methods were used for the analysis.ResultsThe results showed that glutathione reductase, glutathione peroxidase, total antioxidant status and CD4+ T cell count were significantly lowered in symptomatic HIV participants with and without malaria co-infection (P<0.01) in each case compared with control participants. Also, glutathione reductase, glutathione peroxidise, total antioxidant status and CD4+ T cell count were significantly lowered in asymptomatic HIV participants with and without malaria co-infection (P<0.05) in each case, compared with control participants without malaria. Similarly, these antioxidants were significantly lowered in control participants with malaria infection (P<0.05) compared with control participants without malaria. The malaria parasite density in symptomatic HIV infected participants was negatively associated with glutathione reductase (r = ?0.906, P<0.01), glutathione peroxidase (r = ?0.719, P<0.01) and total antioxidant status (r = ?0.824, P<0.01).ConclusionsThe antioxidant activity was affected in HIV infected participants with malaria co-infection. Malaria co-infection in HIV seems to exert additional burden on antioxidants. This calls for concern in malaria endemic areas with increasing prevalence of HIV infection. 相似文献
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