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Waldemar Pruzanski Susan Saito Mahboob Alam Narendranath S. Ranadive 《Inflammation》1988,12(1):99-106
Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP. 相似文献
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Narendranath S. Ranadive I.Aravind Menon Shaila Shirwadkar Suruj D. Persad 《Inflammation》1989,13(5):483-494
The present studies were undertaken to quantitate the initial inflammatory response produced by the photo-generated reactive species in rabbit skin. Rose bengal (RB), a photosensensitizer dye, was injected into the skin sites at various concentrations and exposed to UV-visible light for 30–120 min. The increase in vascular permeability and the accumulation of PMNs were investigated using125I-labeled albumin and51Cr-labeled PMNs. RB at a concentration of 1 nmol with 120-min exposure to light enhanced vascular permeability by 3.7 times and accumulation of PMNs by 3.3 times. As low as 0.01 nmol of RB produced discernible effects.-Carofene (0.1 nmole) inhibited the inflammatory response by 75–100%, suggesting that the reactive species involved in this response was predominantly singlet oxygen. The increase in vascular permeability was inhibited by 48–70% by 25g of chlorpheniramine maleate. It is therefore suggested that histamine plays a major role in the initial vascular response. The studies demonstrate that this rabbit model is suitable for the quantitation of photoinduced inflammatory response which is not observable by gross anatomic procedures.Part of this work was presented at NATO Advanced Study Institute on Photosencitisation, July 1987, Kingston, Canada. This work was supported by research grants from Natural Sciences and Engineering Research Council, Canada and Ontario Ministry of Labour, Canada. 相似文献
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Deepa Jagadeesh MD Navneet S. Majhail MD Yizeng He MS Kwang W. Ahn PhD Carlos Litovich MS Sairah Ahmed MD Mahmoud Aljurf MD Ulrike Bacher MD Sherif M. Badawy MD Nelli Bejanyan MD Mitchell Cairo MD Jan Cerny MD Narendranath Epperla MD Nosha Farhadfar MD César O. Freytes MD Robert Peter Gale MD Bradley Haverkos MD Nasheed Hossain MD David Inwards MD Rammurti T. Kamble MD Vaishalee P. Kenkre MD Hillard M. Lazarus MD Aleksandr Lazaryan MD Lazaros Lekakis MD Matthew Mei MD Hemant S. Murthy MD Alberto Mussetti MD Sunita Nathan MD Taiga Nishihori MD Richard F. Olsson MD Praveen Ramakrishnan Geethakumari MD Bipin N. Savani MD Jean A. Yared MD Timothy S. Fenske MD Mohamed A. Kharfan-Dabaja MD Anna Sureda MD Mehdi Hamadani 《Cancer》2020,126(10):2279-2287
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Gangatirkar P Gangadharan S Narendranath A Nagpal S Salunke DM Karande AA 《Hybridoma and hybridomics》2002,21(4):281-286
Monoclonal antibodies (MAbs) specific to gonadotropin-releasing hormone (GnRH) were obtained using different strategies of conjugation of the peptide to carrier protein and immunization. Of several antibodies obtained, two, namely F1D3C5 and E2D2 bound GnRH in solution phase. Though the epitopes corresponding to the two overlapped, there was a one amino acid shift in the core epitope. These two antibodies were characterized with respect to inhibition of GnRH induced responses in rat pituitary cultures and alpha-T3.1 mouse gonadotrope cell line. 相似文献
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Narendranath Sanji Padmanabha Kaimar Madhusudan Upadya Mohammed K. Riaz 《Indian journal of pharmacology》2013,45(2):204-Apr;45(2):204
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Complex karyotype in patients with mantle cell lymphoma predicts inferior survival and poor response to intensive induction therapy 下载免费PDF全文
I. Brian Greenwell MD Ashley D. Staton MD Michael J. Lee MD Jeffrey M. Switchenko PhD MS Debra F. Saxe PhD Joseph J. Maly MD Kristie A. Blum MD Natalie S. Grover MD Stephanie P. Mathews MD Max J. Gordon MD Alexey V. Danilov MD PhD Narendranath Epperla MD MS Timothy S. Fenske MD Mehdi Hamadani MD Steven I. Park MD Christopher R. Flowers MD MS Jonathon B. Cohen MD MS 《Cancer》2018,124(11):2306-2315
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