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Alain Herment PhD Nadjia Kachenoura PhD Muriel Lefort BS Mourad Bensalah MD Anas Dogui MS Frédérique Frouin PhD Elie Mousseaux MD PhD Alain De Cesare PhD 《Journal of magnetic resonance imaging : JMRI》2010,31(4):881-888
Purpose:
To assess if segmentation of the aorta can be accurately achieved using the modulus image of phase contrast (PC) magnetic resonance (MR) acquisitions.Materials and Methods:
PC image sequences containing both the ascending and descending aorta of 52 subjects were acquired using three different MR scanners. An automated segmentation technique, based on a 2D+t deformable surface that takes into account the features of PC aortic images, such as flow‐related effects, was developed. The study was designed to: 1) assess the variability of our approach and its robustness to the type of MR scanner, and 2) determine its sensitivity to aortic dilation and its accuracy against an expert manual tracing.Results:
Interobserver variability in the lumen area was 0.59 ± 0.92% for the automated approach versus 10.09 ± 8.29% for manual segmentation. The mean Dice overlap measure was 0.945 ± 0.014. The method was robust to the aortic size and highly correlated (r = 0.99) with the manual tracing in terms of aortic area and diameter.Conclusion:
A fast and robust automated segmentation of the aortic lumen was developed and successfully tested on images provided by various MR scanners and acquired on healthy volunteers as well as on patients with a dilated aorta. J. Magn. Reson. Imaging 2010;31:881–888. ©2010 Wiley‐Liss, Inc. 相似文献2.
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Ioannis Bargiotas Elie Mousseaux Wen-Chung Yu Bharath Ambale Venkatesh Emilie Bollache Alain de Cesare Joao A.C. Lima Alban Redheuil Nadjia Kachenoura 《Journal of cardiovascular magnetic resonance》2015,17(1)
Background
Aortic pulse wave velocity (PWV), which substantially increases with arterial stiffness and aging, is a major predictor of cardiovascular mortality. It is commonly estimated using applanation tonometry at carotid and femoral arterial sites (cfPWV). More recently, several cardiovascular magnetic resonance (CMR) studies have focused on the measurement of aortic arch PWV (archPWV). Although the excellent anatomical coverage of CMR offers reliable segmental measurement of arterial length, accurate transit time (TT) determination remains a challenge. Recently, it has been demonstrated that Fourier-based methods were more robust to low temporal resolution than time-based approaches.Methods
We developed a wavelet-based method, which enables temporal localization of signal frequencies, to estimate TT from ascending and descending aortic CMR flow curves. This method (archPWVWU) combines the robustness of Fourier-based methods to low temporal resolution with the possibility to restrict the analysis to the reflectionless systolic upslope. We compared this method with Fourier-based (archPWVF) and time domain upslope (archPWVTU) methods in relation to linear correlations with age, cfPWV and effects of decreasing temporal resolution by factors of 2, 3 and 4. We studied 71 healthy subjects (45 ± 15 years, 29 females) who underwent CMR velocity acquisitions and cfPWV measurements.Results
Comparison with age resulted in the highest correlation for the wavelet-based method (archPWVWU:r = 0.84,p < 0.001; archPWVTU:r = 0.74,p < 0.001; archPWVF:r = 0.63,p < 0.001). Associations with cfPWV resulted in the highest correlations for upslope techniques whether based on wavelet (archPWVWU:r = 0.58,p < 0.001) or time (archPWVTU:r = 0.58,p < 0.001) approach. Furthermore, while decreasing temporal resolution by 4-fold induced only a minor decrease in correlation of both archPWVWU (r decreased from 0.84 to 0.80) and archPWVF (r decreased from 0.63 to 0.51) with age, it induced a major decrease for the archPWVTU age relationship (r decreased from 0.74 to 0.38).Conclusions
By CMR, measurement of aortic arch flow TT using systolic upslopes resulted in a better correlation with age and cfPWV, as compared to the Fourier-based approach applied on the entire cardiac cycle. Furthermore, methods based on harmonic decomposition were less affected by low temporal resolution. Since the proposed wavelet approach combines these two advantages, it might help to overcome current technical limitations related to CMR temporal resolution and evaluation of patients with highly stiff arteries. 相似文献4.
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Anas Dogui Nadjia Kachenoura Frédérique Frouin Muriel Lefort Alain De Cesare Elie Mousseaux Alain Herment 《Journal of cardiovascular magnetic resonance》2011,13(1):11
Background
Arterial stiffness is considered as an independent predictor of cardiovascular mortality, and is increasingly used in clinical practice. This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data.Results
Forty-six healthy subjects underwent carotid-femoral pulse wave velocity measurements (CF_PWV) by applanation tonometry and CMR with steady-state free-precession and phase contrast acquisitions at the level of the aortic arch. These data were used for the automated evaluation of the aortic arch pulse wave velocity (Arch_PWV), and the ascending aorta distensibility (AA_Distc, AA_Distb), which were estimated from ascending aorta strain (AA_Strain) combined with either carotid or brachial pulse pressure. The local ascending aorta pulse wave velocity AA_PWVc and AA_PWVb were estimated respectively from these carotid and brachial derived distensibility indices according to the Bramwell-Hill theoretical model, and were compared with the Arch_PWV. In addition, a reproducibility analysis of AA_PWV measurement and its comparison with the standard CF_PWV was performed. Characterization according to the Bramwell-Hill equation resulted in good correlations between Arch_PWV and both local distensibility indices AA_Distc (r = 0.71, p < 0.001) and AA_Distb (r = 0.60, p < 0.001); and between Arch_PWV and both theoretical local indices AA_PWVc (r = 0.78, p < 0.001) and AA_PWVb (r = 0.78, p < 0.001). Furthermore, the Arch_PWV was well related to CF_PWV (r = 0.69, p < 0.001) and its estimation was highly reproducible (inter-operator variability: 7.1%).Conclusions
The present work confirmed the consistency and robustness of the regional index Arch_PWV and the local indices AA_Distc and AA_Distb according to the theoretical model, as well as to the well established measurement of CF_PWV, demonstrating the relevance of the regional and local CMR indices. 相似文献6.
Independent component analysis for rectal bleeding prediction following prostate cancer radiotherapy
Auréline Fargeas Oscar Acosta Juan David Ospina Arrango Amine Ferhat Nathalie Costet Laurent Albera David Azria Pascal Fenoglietto Gilles Créhange Véronique Beckendorf Mathieu Hatt Amar Kachenoura Renaud de Crevoisier 《Radiotherapy and oncology》2018,126(2):263-269
Background and purpose
To evaluate the benefit of independent component analysis (ICA)-based models for predicting rectal bleeding (RB) following prostate cancer radiotherapy.Materials and methods
A total of 593 irradiated prostate cancer patients were prospectively analyzed for Grade ≥2 RB. ICA was used to extract two informative subspaces (presenting RB or not) from the rectal DVHs, enabling a set of new parameters to be estimated. These DVH-based parameters, along with others from the principal component analysis (PCA) and functional PCA, were compared to “standard” features (patient/treatment characteristics and DVH bins) using the Cox proportional hazards model for RB prediction. The whole cohort was divided into: (i) training (N?=?339) for ICA-based subspace identification and Cox regression model identification and (ii) validation (N?=?254) for RB prediction capability evaluation using the C-index and the area under the receiving operating curve (AUC), by comparing predicted and observed toxicity probabilities.Results
In the training cohort, multivariate Cox analysis retained and PC as significant parameters of RB with 0.65 C-index. For the validation cohort, the C-index increased from 0.64 when was not included in the Cox model to 0.78 when including parameters. When was not included, the AUC for 3-, 5-, and 8-year RB prediction were 0.68, 0.66, and 0.64, respectively. When included, the AUC increased to 0.83, 0.80, and 0.78, respectively.Conclusion
Among the many various extracted or calculated features, ICA parameters improved RB prediction following prostate cancer radiotherapy. 相似文献7.
Impaired atrioventricular transport in patients with transposition of the great arteries palliated by atrial switch and preserved systolic right ventricular function: A magnetic resonance imaging study
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Magalie Ladouceur MD Nadjia Kachenoura PhD Gilles Soulat MD Emilie Bollache PhD Alban Redheuil MD PhD Michel Azizi MD PhD Christophe Delclaux MD PhD Gilles Chatellier MD PhD Pierre Boutouyrie MD PhD Laurence Iserin MD Damien Bonnet MD PhD Elie Mousseaux MD PhD 《Congenital heart disease》2017,12(4):458-466
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Nadjia Kachenoura Federico Veronesi Joseph A. Lodato Cristiana Corsi Rupa Mehta Barbara Newby Roberto M. Lang Victor Mor-Avi 《European radiology》2010,20(2):337-347
Background
Although the ability of multi-detector computed tomography (MDCT) to detect perfusion abnormalities associated with acute and chronic myocardial infarction (MI) has been demonstrated, this methodology is based on visual interpretation of selected 2D slices. 相似文献10.
A computer-assisted method is proposed to estimate transmural extent of myocardial infarction. In 40 patients with chronic myocardial infarction and 3 control subjects, late gadolinium enhancement images were acquired with magnetic resonance imaging. Segmental infarct transmural extent was visually assessed by two experts on a 5-point scale. A fuzzy c-means algorithm was applied on both the cavity and myocardium to estimate an enhancement index for 12 sub-regions of each segment. A threshold was defined on a training database (n=29) to establish the transmurality extent of each sub-segment and was applied to the validation database (n=14). Inter-observer reproducibility reached an absolute agreement (Aa) of 85% and a kappa value (kappa) of 0.83 when considering the whole training database; Aa decreased to 62% and kappa to 0.68 when excluding homogeneous segments. On the validation database, segments were subdivided into three angular sub-segments. Then, inter-observer visual reproducibility reached Aa of 93% and kappa of 0.92. Moreover, the absolute comparison of each expert with the computer-assisted method yielded Aa higher than 88% and kappa higher than 0.86. The computer-assisted method quantifies infarct transmurality without defining remote and infarcted regions, and the transmural extent is accurately characterized when dividing each segment into three angular sub-segments. 相似文献