Developmental pattern of androgen-regulated proteins in seminal vesicles from the mouse

Proteins from secretions or homogenates of mice seminal vesicles were analysed by polyacrylamide gel electrophoresis. In homogenates about 15 bands were differentially induced with molecular weights (MW's) of 12, 13, 14, 15, 15.5, 71, 120 and 140 kD, or repressed molecular weights of 12.5, 14.3, 28, 30, 53, 73, 90-105 kD). The effects of castration were reversed by testosterone and dihydrotestosterone but not by oestradiol, progesterone or corticosterone. When the androgen-dependence of proteins was investigated using radioactive methionine the protein spectra showed that about 12 bands with molecular weights of 13, 13.7, 14, 15, 15.5, 16, 20.5, 24, 37, 38.5, 56, 68, 96 and 180 kD were differentially induced or repressed by androgens. Of the induced proteins, those with low molecular weight (12-15.5 kD) were accumulated in significant amounts between 20 days and 30 days, coincident with the pubertal increase of androgens in the seminal vesicles. Those induced proteins with high molecular weight (71, 120 and 140 kD) appeared between 40 days and 60 days. The androgen-repressed proteins were strongly evident in immature males, but disappeared after day 40.     

A sporotrichoid-like Mycobacterium kansasii infection of the skin treated with minocycline hydrochloride

A sporotrichoid-like Mycobacterium kansasii infection of the skin is reported. This is the fifth reported case in the English literature of dermatological manifestations of a M. kansasii infection and the first reported case of a response to minocycline hydrochloride therapy.     

A new programme for public health training in Hungary

The emergence of democracy has led the countries of centraland eastern Europe to undertake a fundamental reappraisal oftheir public health services and training requirements. Thispaper describes the thinking behind the changes under way inHungary. These involve a radical departure from the way publichealth medicine was taught. It was traditionally divided betweendepartments of hygiene and social medicine. The hygiene departmentshad a very narrow focus, mainly on aspects of communicable diseaseepidemiology, food hygiene, occupational hygiene, environmentalhygiene and toxicology. Social medicine was principally concernedwith health service management, although more recently it hasincluded some non-communicable disease epidemiology. A new postgraduatetraining programme in public health medicine will be developedin which non-communicable disease epidemiology will be strengthenedand subjects such as health economics and health promotion willbe incorporated. Training will take place in a multi-disciplinarysetting and additional programmes for other professional groupswill be developed and Integrated.