全文获取类型
收费全文 | 8936篇 |
免费 | 669篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 205篇 |
儿科学 | 293篇 |
妇产科学 | 243篇 |
基础医学 | 1117篇 |
口腔科学 | 220篇 |
临床医学 | 879篇 |
内科学 | 1789篇 |
皮肤病学 | 72篇 |
神经病学 | 909篇 |
特种医学 | 385篇 |
外国民族医学 | 2篇 |
外科学 | 1371篇 |
综合类 | 161篇 |
一般理论 | 6篇 |
预防医学 | 809篇 |
眼科学 | 138篇 |
药学 | 527篇 |
2篇 | |
中国医学 | 9篇 |
肿瘤学 | 492篇 |
出版年
2021年 | 111篇 |
2020年 | 79篇 |
2019年 | 123篇 |
2018年 | 122篇 |
2017年 | 90篇 |
2016年 | 100篇 |
2015年 | 146篇 |
2014年 | 182篇 |
2013年 | 249篇 |
2012年 | 370篇 |
2011年 | 426篇 |
2010年 | 258篇 |
2009年 | 230篇 |
2008年 | 366篇 |
2007年 | 397篇 |
2006年 | 333篇 |
2005年 | 359篇 |
2004年 | 339篇 |
2003年 | 329篇 |
2002年 | 334篇 |
2001年 | 285篇 |
2000年 | 277篇 |
1999年 | 235篇 |
1998年 | 99篇 |
1997年 | 104篇 |
1996年 | 95篇 |
1995年 | 100篇 |
1994年 | 85篇 |
1993年 | 88篇 |
1992年 | 212篇 |
1991年 | 214篇 |
1990年 | 208篇 |
1989年 | 204篇 |
1988年 | 182篇 |
1987年 | 192篇 |
1986年 | 195篇 |
1985年 | 183篇 |
1984年 | 137篇 |
1983年 | 114篇 |
1982年 | 79篇 |
1980年 | 72篇 |
1979年 | 132篇 |
1978年 | 98篇 |
1977年 | 71篇 |
1976年 | 81篇 |
1975年 | 88篇 |
1974年 | 79篇 |
1973年 | 76篇 |
1972年 | 90篇 |
1971年 | 75篇 |
排序方式: 共有9629条查询结果,搜索用时 15 毫秒
1.
Nicholas E. Anton Tomoko Mizota Lava R. Timsina Jake A. Whiteside Erinn M. Myers Dimitrios Stefanidis 《American journal of surgery》2019,217(2):266-271
Introduction
Several studies demonstrated that simulator-acquired skill transfer to the operating room is incomplete. Our objective was to identify trainee characteristics that predict the transfer of simulator-acquired skill to the operating room.Methods
Trainees completed baseline assessments including intracorporeal suturing (IS) performance, attentional selectivity, self-reported use of mental skills, and self-reported prior clinical and simulated laparoscopic experience and confidence. Residents then followed proficiency-based laparoscopic skills training, and their skill transfer was assessed on a live-anesthetized porcine model. Predictive characteristics for transfer test performance were assessed using multiple linear regression.Results
Thirty-eight residents completed the study. Automaticity, attentional selectivity, resident perceived ability with laparoscopy and simulators, and post-training IS performance were predictive of IS performance during the transfer test.Conclusions
Promoting automaticity, self-efficacy, and attention selectivity may help improve the transfer of simulator-acquired skill. Mental skills training and training to automaticity may therefore be valuable interventions to achieve this goal. 相似文献2.
Susan E. Hickman Alexia M. Torke Greg A. Sachs Rebecca L. Sudore Anne L. Myers Qing Tang Giorgos Bakoyannis Bernard J. Hammes 《Journal of pain and symptom management》2019,57(6):1143-1150.e5
ContextIt is especially important that patients are well informed when making high-stakes, preference-sensitive decisions like those on the Physician Orders for Life-Sustaining Treatment (POLST) form. However, there is currently no way to easily evaluate whether patients understand key concepts when making these important decisions.ObjectivesTo develop a POLST knowledge survey.MethodsExpert (n = 62) ratings of key POLST facts were used to select items for a POLST knowledge survey. The survey was administered to nursing facility residents (n = 97) and surrogate decision-makers (n = 112). A subset (n = 135) were re-administered the survey after a standardized advance care planning discussion to assess the scale's responsiveness to change.ResultsThe 19-item survey demonstrated adequate reliability (α = 0.72.). Residents' scores (x = 11.4, standard deviation 3.3) were significantly lower than surrogate scores (x = 14.7, standard deviation 2.5) (P < 0.001). Scores for both groups increased significantly after administration of a standardized advance care planning discussion (P < 0.001). Although being a surrogate, age, race, education, cognitive functioning, and health literacy were significantly associated with higher POLST Knowledge Survey scores in univariate analyses, only being a surrogate (P < 0.001) and being white (P = 0.028) remained significantly associated with higher scores in multivariate analyses.ConclusionThe 19-item POLST Knowledge Survey demonstrated adequate reliability and responsiveness to change. Findings suggest the survey could be used to identify knowledge deficits and provide targeted education to ensure adequate understanding of key clinical decisions when completing POLST. 相似文献
3.
4.
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists 总被引:1,自引:0,他引:1
A P Welbourn C B Chapleo A C Lane P L Myers A G Roach C F Smith M R Stillings I F Tulloch 《Journal of medicinal chemistry》1986,29(10):2000-2003
The resolution of three 2-substituted derivatives of idazoxan is described. The enantiomers show large separations in activity in a variety of in vitro and in vivo tests, and the active isomers are all potent and selective antagonists at the alpha 2-adrenoreceptor. The significance of these results in relation to those published on the enantiomers of idazoxan and to those on optically active alpha 2-adrenoreceptor agonists is discussed. 相似文献
5.
6.
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells 总被引:65,自引:10,他引:55
PADGEM protein (PADGEM), also known as GMP140, is a platelet alpha- granule membrane protein that is translocated to the external membrane after platelet activation. Although the biosynthesis of this protein was originally thought to be confined to megakaryocytes, the synthesis of PADGEM in endothelial cells was recently demonstrated (McEver et al: Blood 70:1974a, 1987). We now describe the subcellular localization of this protein in endothelial cells. Immunofluorescence staining of permeabilized human umbilical vein endothelial cells with KC4, a well characterized monoclonal antibody to PADGEM, showed positively stained elongated structures similar in distribution and shape to Weibel-Palade bodies. Their identity as Weibel-Palade bodies was confirmed by double label immunofluorescence using KC4 and a polyclonal antiserum to von Willebrand factor (vWf), a protein known to be specifically stored in these organelles. All Weibel-Palade bodies were found to contain PADGEM. In contrast to strong perinuclear staining produced with anti- vWf antibodies, no significant perinuclear staining was obtained with KC4, indicating that relatively little PADGEM is present in the endoplasmic reticulum and in the Golgi apparatus. In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, further identifying these structures as Weibel-Palade bodies. This observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWf and PADGEM. 相似文献
7.
A H Myers B Rosner H Abbey W Willet M J Stampfer C Bain R Lipnick C Hennekens F Speizer 《American journal of public health》1987,77(5):628-630
We analyzed smoking behavior of 91,651 married female nurses, aged 30-55 years in 1976. The prevalence of smoking was similar among all birth cohorts. The largest percentage increase in starting to smoke occurred between ages 15 and 25 years; by age 25, 50 per cent had started smoking. The cessation rate was lowest in earlier birth cohorts and among nurses starting to smoke at earlier ages. The cessation rate increased substantially between 1963-73 compared with the period 1948-58. 相似文献
8.
9.
10.