全文获取类型
收费全文 | 207篇 |
免费 | 15篇 |
专业分类
儿科学 | 5篇 |
妇产科学 | 25篇 |
基础医学 | 24篇 |
口腔科学 | 14篇 |
临床医学 | 18篇 |
内科学 | 35篇 |
神经病学 | 5篇 |
特种医学 | 14篇 |
外科学 | 14篇 |
综合类 | 25篇 |
预防医学 | 6篇 |
药学 | 21篇 |
中国医学 | 6篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 8篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 4篇 |
2013年 | 8篇 |
2012年 | 8篇 |
2011年 | 6篇 |
2010年 | 3篇 |
2009年 | 5篇 |
2008年 | 1篇 |
2007年 | 2篇 |
2006年 | 11篇 |
2005年 | 9篇 |
2004年 | 5篇 |
2003年 | 9篇 |
2002年 | 3篇 |
2001年 | 5篇 |
2000年 | 12篇 |
1999年 | 16篇 |
1998年 | 9篇 |
1997年 | 19篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 4篇 |
1983年 | 1篇 |
1980年 | 3篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有222条查询结果,搜索用时 15 毫秒
1.
Regnier V; Meddeb M; Lecointre G; Richard F; Duverger A; Nguyen VC; Dutrillaux B; Bernheim A; Danglot G 《Human molecular genetics》1997,6(1):9-16
Type 1 neurofibromatosis (NF1) gene encodes for a member of the GTPase
activating protein family and is considered to be a tumor suppressor gene.
Its very high rate of de novo mutation in humans led us to study a specific
feature of this gene: the presence of numerous NF1-related sequences.
According to our results, the human genome contains at least 11 NF1-related
sequences, nine of which are scattered near centromeric sequences of seven
different chromosomes. These NF1-related sequences, whose extent is quite
varied according to loci, are unprocessed copies of the NF1 gene, and bear
numerous mutations. A phylogenetic analysis of the six largest sequences
indicates that they are all derived from a common ancestor, which would
have appeared 22-33 million years ago, and was subsequently duplicated
several times during hominoid evolution. The most recent duplication and
interchromosomal transposition occurred in the last million years
suggesting that the process could still be ongoing. Intriguing similarities
between the evolution of alpha- satellite DNA and NF1-related sequences
suggest the involvement of a common genetic mechanism for the generation
and pericentric spreading of these NF1 partial copies.
相似文献
2.
G. M. Brieger M. Mongelli L. Y. Hin T. K. H. Chung 《International urogynecology journal》1997,8(4):191-195
The epidemiology of urinary dysfunction in a Chinese population living in Hong Kong was investigated. Fifteen hundred ethnic
Chinese women answered a telephone questionnaire including symptoms of urinary dysfunction, anthropometric measurements, obstetric
history and place of birth. The relative predictive value of these factors was analyzed using logistic regression. The prevalence
of urinary dysfunction was 13%. Ten percent reported stress incontinence, and 4% had urgency or urge incontinence. The strongest
predictor was place of birth, with women born in mainland China having the highest prevalence of pure stress incontinence
(OR 1.33, CI 1.1–1.6). For the symptoms of detrusor instability age was the strongest predictor, with women over 50 years
being at greater risk (OR 2.8, CI 1.6–5.0). Contrary to earlier beliefs, urinary dysfunction in Chinese women is as common
as in Caucasian women. Place of birth is the strongest predictor for pure stress incontinence, with women born in mainland
China being at greater risk. This suggests that environmental factors in early life have a differential effect on the development
of urinary incontinence.
EDITORIAL COMMENT: Taiwan Chinese women have a comparable prevalence of urinary dysfunction with Hong Kong Chinese women.
A survey representing a multistage sample of 82 678 women aged 18 years or older was conducted in the Taipei area from January
to June 1993. A total of 818 cases were interviewed by trained students. One hundred and eighty-nine (23.1%) of the respondents
reported having had some degree of incontinence in the preceding 12 months, 28 (3.4%) reporting regular incontinence. Most
presented with stress urinary incontinence, whereas urge incontinence and mixed incontinence were more commonly seen in the
elderly group (aged 60 years or older). The risk factors for urinary incontinence included age, number of vaginal deliveries
(>3), number of abortions (>2) and maternal history of incontinence. Voiding symptoms (irritative or obstructive) and constipation
were significantly more prevalent among respondents with incontinence than those without (P<0.001). This evidence also indicates that the long-held belief that Chinese women have a much lower prevalence of urinary
dysfunction than western women has all but ended. 相似文献
3.
Arbour NC; Zlotogora J; Knowlton RG; Merin S; Rosenmann A; Kanis AB; Rokhlina T; Stone EM; Sheffield VC 《Human molecular genetics》1997,6(5):689-694
Achromatopsia is an autosomal recessive disease of the retina,
characterized clinically by an inability to distinguish colors, impaired
visual acuity, nystagmus and photophobia. A genome-wide search for linkage
was performed using an inbred Jewish kindred from Iran. To facilitate the
genome-wide search, we utilized a DNA pooling strategy which takes
advantage of the likelihood that the disease in this inbred kindred is
inherited by all affected individuals from a common founder. Equal molar
amounts of DNA from all affected individuals were pooled and used as the
PCR template for short tandem repeat polymorphic markers (STRPs). Pooled
DNA from unaffected members of the kindred was used as a control. A
reduction in the number of alleles in the affected versus control pool was
observed at several loci. Upon genotyping of individual family members,
significant linkage was established between the disease phenotype and
markers localized on chromosome 2. The highest LOD score observed was 5.4
(theta = 0). When four additional small unrelated families were genotyped,
the combined peak LOD score was 8.2. Analysis of recombinant chromosomes
revealed that the disease gene lies within a 30 cM interval which spans the
centromere. Additional fine-mapping studies identified a region of
homozygosity in all affected individuals, narrowing the region to 14 cM. A
candidate gene for achromatopsia was excluded from this disease interval by
radiation hybrid mapping. Linkage of achromatopsia to chromosome 2 is an
essential first step in the identification of the disease-causing gene.
相似文献
4.
Two-hundred and eighty bacterial isolates from wound and soft tissue infections were studied for species identification and antibiotic resistance pattern. Amongst them 122 isolates were from community acquired infection and 158 were from nosocomial infections. The common community acquired pathogens were Staphylococcus aureus (67.8%) and Streptococcus pyogenes (10.7%), whereas Staphylococcus aureus (60.1%) and E. Coli (8.9%) were common in nosocomial infection. Only two anaerobes (Cl perfringens) were isolated. Penicillin resistance was found to be 87% and 92% for Staphylococccus aureus in community acquired and noscomial infections respectively. 85% of Proteus isolates were resistant to ampicillin. There was relatively lower level of resistance by all isolates to cefotaxime. Gentamicin showed higher rate of resistance than netilmicin and amikacin. Resistance of E. coli isolates to fluoroquinolones being 79% for norfloxacin, 81% for ciprofloxacin and 60% for ofloxacin. The study showed a higher resistance of methicillin resistant Staphylococcus aureus (MRSA) to other antibiotics. Amikacin and ofloxacin were the best recommended drugs for empirical therapy for all organisms, the susceptibility rate being 80.7% and 80.4%.KEY WORDS: Antibiotic resistance, Soft tissue infections, Wound infections 相似文献
5.
6.
The insecticidal activity of the leaves of Pothomorphe peltata (Piperaceae) was evaluated on Aedes aegypti larvae. The active methanol extract was subjected to a bioactivity-directed fractionation, monitored by the larvicidal assay, and led to the isolation of a catechol derivative, 4-nerolidylcatechol. This compound was quite potent against Aedes aegypti larvae (LC(50) = 9.1 microg/mL). 相似文献
7.
8.
9.
Floriana Campanile Gino Mongelli Dafne Bongiorno Chiara Adembri Milva Ballardini Marco Falcone Francesco Menichetti Antonella Repetto Carla Sabia Assunta Sartor Claudio Scarparo Carlo Tascini Mario Venditti Federica Zoppi Stefania Stefani 《Journal of clinical microbiology》2013,51(4):1256-1259
In order to assess the frequency of clinically relevant linezolid-resistant staphylococcal isolates, and the role of linezolid in maintaining and coselecting multiple resistance mechanisms (cfr, 23S rRNA, L3/L4 mutations), a prospective Italian study was performed from 2010 to 2011 to confirm the diffusion of three major multidrug-resistant clones (ST2, ST5, ST23). 相似文献
10.
Patient perspectives on de‐simplifying their single‐tablet co‐formulated antiretroviral therapy for societal cost savings 下载免费PDF全文