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排序方式: 共有569条查询结果,搜索用时 10 毫秒
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Shigeko Tanaka Minoru Yoshiyama Yukihiro Imanishi Koichi Nakahira Takashi Hanaki Yukari Naito Mizue Imai Masahiro Tanaka 《Magnetic resonance in medical sciences》2006,5(4):207-210
One diagnostic criterion for metabolic syndrome is obesity from the accumulation of visceral fat; others include abdominal circumference and area of visceral fat as measured by computed tomography (CT) at the umbilical level. We evaluated visceral fat using frequency-selective excitation magnetic resonance (MR) imaging SPAIR (spectral attenuation with inversion recovery) water suppression THRIVE (3D T1-high resolution isotropic volume examination). Fifty of 70 slices with 2-mm interval were used to render and measure volume of visceral fat ranging within 10 cm of the umbilicus; the area of visceral fat at the umbilical level was also measured. Imaging was completed using breath hold within 14 s. Image processing was easier than using CT. 相似文献
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V. Ventafridda E. Oliveri A. Caraceni E. Spoldi F. De Conno L. Saita C. Ripamonti 《Journal of pain and symptom management》1987,2(2):77-81
The authors report a retrospective study of 390 cancer pain patients tested with oral morphine during a four-month period. Initial pain scores were reduced to one half after one week of treatment and then maintained throughout the study period. Mean daily dosages of morphine were lower in those patients 65 years and older. No significant changes in performance in relation to therapy were noted except for an increase in hours of sleep. An accurate titration of dosage and continued control of side effects are the main requirements of this method of administration. The presence of side effects and the cause of interruption of treatment are reported. 相似文献
5.
Yuta Ishizuka Yasushi Ishida Qing-Hua Jin Ayumi Shimokawa Mitsuhiko Saita Kazuo Kato Takato Kunitake Takamitsu Hanamori Yoshio Mitsuyama Hiroshi Kannan 《Brain research》1998,789(1):10
Nitric oxide (NO) has recently been shown to modulate the hypothalamic–pituitary–adrenal axis response to interleukin-1β (IL-1β). We measured levels of nitrite (NO2−) and nitrate (NO3−) in the hypothalamic paraventricular nucleus (PVN) region using an in vivo brain microdialysis technique in conscious rats. Intraperitoneally administered IL-1β produced a significant increase in both NO2− and NO3− levels in the PVN region. We also examined the possible involvement of the abdominal vagal afferent nerves in this effect. In abdominal-vagotomized rats, the increase was significantly attenuated compared to that in sham-operated rats. Our results suggest that the abdominal vagal afferent nerves are involved in intraperitoneally administered IL-1β-induced NO release in the PVN region. 相似文献
6.
Nakama S Kikuchi M Yashiro T Sakamoto A Kikkawa I Ookami H Saita K Hoshino Y 《Medical molecular morphology》2005,38(3):173-180
Ossification or calcification of the ligamentum flavum (LF) is relatively common in the middle and lower cervical, thoracic, and lumbar spine but extremely rare in the upper cervical region. This clinical fact suggests that there exist local factors promoting or preventing ossification or calcification of LF. However, little is known about the differences in the ultrastructure and cellular alterations of the LF between the different spinal levels, even in the cervical spine. With electron microscopy, we examined samples of LF collected surgically from the upper and lower cervical spine regions; we then studied the apoptotic appearance of ligament cells using a preferential labeling method. We found direct evidence of apoptosis of ligament cells in the LF. Apoptosis was more apparent in the upper region samples than in the lower region samples. The spaces around the normal fibroblasts were filled with thick collagen fibrils, but the collagen fibrils disappeared around the apoptotic bodies and thin fibrils were formed. The difference of the level of apoptosis may correlate to the ultrastructual difference of LF, and our data will benefit further investigations seeking to clarify the mechanism of various pathological conditions in the human LF. 相似文献
7.
Yamanaka T Saita N Kawano O Matsumoto M Kohrogi H Suga M Ando M Hirashima M 《International archives of allergy and immunology》2000,122(1):66-75
BACKGROUND: We established a T cell line, STO-5, which constitutively produced monocyte/macrophage chemotactic activity via human T cell lymphoma-leukemia-virus-induced transformation of normal human T cells. METHODS: We isolated and purified a lactose-binding protein, MCF-pl5-L (MW of about 50 kD, pl of about 5) from a conditioned medium of STO-5. By using highly purified MCF-pl5-L, its biological and physicochemical properties were elucidated in comparison with C5a and MCP-1. RESULTS: MCF-pl5-L exhibited an evident dose-dependent monocyte chemotactic activity (MCA). MCF-pl5-L had no or little affinity for heparin unlike chemokines such as MCP-1. We further found that MCF-pl5-L exhibited potent chemotactic activity not only for monocytes but also for alveolar macrophages. In contrast, C5a and MCP-1 failed to show evident chemotactic activity for alveolar macrophages though they did show MCA. MCF-pl5-L failed to exhibit evident eosinophil and neutrophil chemotactic activities, indicating its chemotactic activity is selective for monocytes/macrophages. Regarding the biological functions of MCF-pl5-L other than MCA and chemotactic activity for alveolar macrophages, we found that MCF-pl5-L but not C5a and MCP-1 could prolong the life span of alveolar macrophages, probably by inhibiting apoptosis of macrophages, and stimulate the production of TNF-alpha from macrophages. CONCLUSIONS: These results suggest that MCF-pl5-L plays a role as an immune modulator for monocytes/macrophages in the site. 相似文献
8.
Robson C. Gutierre Mizue I. Egami Marta M. Antoniazzi Carlos Jared 《Comparative clinical pathology》2008,17(4):221-228
The caecilians (Amphibia, Gymnophiona) constitute one of the least known groups of terrestrial vertebrates because most species
live underground in quite inaccessible environments. Siphonops annulatus is an exclusively fossorial species and is the most extensively distributed caecilian in South America. Little is known of
this order concerning circulating granulocytes, including their morphological and cytochemical structure and ultrastructure.
This paper is part of a project covering the study of granulocytes in representative species of the order Amphibia. Blood
extensions were carried out and submitted to Leishman, Toluidine Blue, Periodic acid Schiff, Sirius Red and hydrogen o-toluidine peroxide methods. Part of the samples was prepared for conventional transmission electron microscopy. Among granular
leukocytes, mature and immature neutrophils and eosinophils were identified, plus basophils. The most frequent granulocyte
encountered in S. annulatus peripheral blood is the neutrophil. This is a cell with a hyper-segmented nucleus and with a very clear cytoplasm when compared
to the eosinophil, which presents large cytoplasmic acidophilic granules. On the other hand, the basophils present basophilic
and metachromatic granules. Glycogen was detected in the cytoplasm of the neutrophils and eosinophils, while basic protein
rich in amino acids was observed in the eosinophil’s granules. Myeloperoxidase activity was detected in the cytoplasm of the
neutrophils and eosinophils. Neutrophils were ultrastructurally detected with three types of small granules: eosinophils with
large and small spherical granules and basophils with large spherical granules with lamellate structures. 相似文献
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Takatsugu Yamamoto Mizue Tamura Toshikazu Hamauzu Akiko Nakayama Kazuo Kawasugi Masahide Kamakura Tadatoshi Kinoshita Yasushi Kuyama Masami Yamanaka Li-man Wang Masaki Sanaka Satoru Mineshita 《Journal of gastroenterology》1997,32(2):241-245
A 45-year-old man with intestinal Behçet's disease noticed an enlarged right cervical lymph node, and was diagnosed with diffuse large cell type, non-Hodgkin's lymphoma. The intrapelvic lymph tract was markedly deformed because of recurrent ileocecal ulceration, and conventional lymphoscintigraphy with a common tracer did not abolish the suspicion that lymphoma cells may have invaded the lymph nodes. Dynamic lymphoscintigraphy with a new tracer,99mtechnetium-diethylene triamine pentaacetic acid-human serum albumin, because of its high detection sensitivity, was very useful for excluding this suspicion, and for determining the clinical stage of lymphoma. Combination induction chemotherapy led to complete remission without any adverse effects, but subsequent supportive therapy with same protocol could not be completed because of progression of the intestinal lesions. Special management for the intestinal lesions, such as bowel rest, may be essential with chemotherapy for patients with intestinal Behçet's disease. 相似文献