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1.
This report describes a simple electronic device employing a piezoelectric element which serves as a sensitive detector of motion. The device is useful as a monitor of respiratory motion for nuclear magnetic resonance animal experiments in vivo. It can also provide a trigger pulse for respiratory gating experiments. 相似文献
2.
S M Rahman B T McKibben T G Hardy C D Schloss C C Cho R F Hartmann P S Aguilar K S Khanduja W R Stewart 《Southern medical journal》1990,83(7):774-777
From January 1979 to October 1986, 86 patients with surgically resectable adenocarcinoma of the rectum or rectosigmoid were treated with adjuvant radiotherapy consisting of preoperative 2,400 cGy (22 patients), preoperative 4,000 cGy (14 patients), "sandwich" technique (27 patients), and postoperative irradiation (23 patients). Average follow-up was 42.9 months. The local recurrence rate was 4.5%, 9.1%, 7.4%, and 34.8%, respectively. The distant metastasis rate was 18.2%, 18.2%, 7.4%, and 30.4%, respectively. Preoperative radiotherapy with adequate surgical resection appears more effective in reducing the incidence of local recurrence. 相似文献
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Louis Georges Castonguay Ph.D. Jean Proulx Ph.D. Jocelyn Aubut M.D. André McKibben M.A. Michel Campbell Ph.D. 《Archives of sexual behavior》1993,22(4):325-334
A current method used to assess the sexual preference of sexual aggressors is the recording of their penile responses during the presentation of erotic stimuli. This method is ineffective in subjects who do not obtain sufficient penile responses. Whether variables related either to the subjects or their crimes would correlate with the magnitude of penile responses during sexual preference assessment was studied. The penile responses of 92 subjects were recorded. Older and presentencing subjects showed a lower maximum penile response magnitude than younger and sentenced subjects. Results are discussed as they relate to the validity of physiological assessment of sexual preference. 相似文献
7.
3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors 总被引:2,自引:0,他引:2
Stewart M Steinig AG Ma C Song JP McKibben B Castelhano AL MacLennan SJ 《Biochemical pharmacology》2004,68(2):305-312
Until recently, the characterization of adenosine A(2B) receptors has been hampered by the lack of high affinity radioligands. This study describes the synthesis and in vitro characterization of the radiolabeled derivative of OSIP339391, a novel, potent, and selective pyrrolopyrimidine A(2B) antagonist. OSIP339391 had a selectivity of greater than 70-fold for A(2B) receptors over other human adenosine receptor subtypes. The radiolabel was introduced by hydrogenation of the acetylenic precursor with tritium gas resulting in the incorporation (on average) of three tritium atoms in the molecule, yielding a ligand with specific activity of 87Ci/mmol (3.2TBq/mmol). Using membranes from HEK-293 cells expressing the human recombinant A(2B) receptor, [3H]OSIP339391 was characterized in kinetic, saturation, and competition binding experiments. From the association and dissociation rate studies, the affinity was 0.41nM and in close agreement with that found in saturation binding experiments (0.17nM). In competition, binding studies using 0.5nM [3H]OSIP339391, the affinity of a range of agonists and antagonists was consistent with previously reported data. Thus, [3H]OSIP339391 is a novel, selective, and high affinity radioligand that can be a useful tool in the further exploration and characterization of recombinant and endogenous adenosine A(2B) receptors. 相似文献
8.
The Advisory Committee on Immunization Practices recognizes the need for evidence-based policy to improve the delivery and receipt of immunization services recommended for adults (i.e., persons aged > or = 18 years). Two recent, systematic reviews of the health services research literature recommended standing orders programs as an effective organizational intervention to improve vaccination coverage rates among adults. This report briefly reviews the evidence on the effectiveness of standing orders programs, describes standards for program implementation, and recommends initiating these programs to improve immunization coverage in several traditional and nontraditional settings. 相似文献
9.
Proulx Jean Aubut Jocelyn McKibben André Côté Martine 《Archives of sexual behavior》1994,23(3):295-310
The sexual arousal profile of a subgroup of rapists with a history of low-level physical violence during their offenses was assessed. Twenty subjects participated: 10 rapists and 10 nonrapists. Stimuli consisted of audiotapes with the following five thematic contents: mutually consenting sexual activities; rape involving physical violence; rape involving humiliation; physical aggression without sexual activities; neutral. Penile responses were recorded during stimuli presentation using a mercury-in-rubber strain gauge. Data showed no differences between both groups for the rape stimuli involving physical violence. For the rape stimuli involving humiliation, however, the penile responses of the two groups differed. With those stimuli the average penile response of the rapists was higher than that of the nonrapists. Therefore, for this subgroup of rapists the association between sexual activities and humiliation presents a higher erotic value than the association between sexual activities and physical violence. Implication of these results as to the discriminant validity and classificatory accuracy of phallometry in rapists is discussed. 相似文献
10.
Reti IM Xu JZ Yanofski J McKibben J Uhart M Cheng YJ Zandi P Bienvenu OJ Samuels J Willour V Kasch-Semenza L Costa P Bandeen-Roche K Eaton WW Nestadt G 《Comprehensive psychiatry》2011,(2):188-194