全文获取类型
收费全文 | 1804篇 |
免费 | 107篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 62篇 |
妇产科学 | 23篇 |
基础医学 | 197篇 |
口腔科学 | 23篇 |
临床医学 | 145篇 |
内科学 | 494篇 |
皮肤病学 | 66篇 |
神经病学 | 121篇 |
特种医学 | 76篇 |
外科学 | 324篇 |
综合类 | 6篇 |
预防医学 | 28篇 |
眼科学 | 16篇 |
药学 | 126篇 |
中国医学 | 9篇 |
肿瘤学 | 183篇 |
出版年
2023年 | 8篇 |
2022年 | 12篇 |
2021年 | 42篇 |
2020年 | 21篇 |
2019年 | 21篇 |
2018年 | 37篇 |
2017年 | 29篇 |
2016年 | 38篇 |
2015年 | 44篇 |
2014年 | 50篇 |
2013年 | 59篇 |
2012年 | 96篇 |
2011年 | 102篇 |
2010年 | 64篇 |
2009年 | 48篇 |
2008年 | 109篇 |
2007年 | 103篇 |
2006年 | 86篇 |
2005年 | 103篇 |
2004年 | 85篇 |
2003年 | 96篇 |
2002年 | 74篇 |
2001年 | 39篇 |
2000年 | 38篇 |
1999年 | 46篇 |
1998年 | 24篇 |
1997年 | 17篇 |
1996年 | 11篇 |
1995年 | 17篇 |
1994年 | 16篇 |
1993年 | 20篇 |
1992年 | 40篇 |
1991年 | 26篇 |
1990年 | 40篇 |
1989年 | 28篇 |
1988年 | 35篇 |
1987年 | 14篇 |
1986年 | 20篇 |
1985年 | 21篇 |
1984年 | 14篇 |
1983年 | 15篇 |
1981年 | 9篇 |
1980年 | 6篇 |
1979年 | 14篇 |
1978年 | 16篇 |
1977年 | 9篇 |
1975年 | 10篇 |
1974年 | 6篇 |
1969年 | 7篇 |
1968年 | 15篇 |
排序方式: 共有1922条查询结果,搜索用时 15 毫秒
1.
Active production of anti-human T-lymphotropic virus type I (HTLV-I) IgM antibody in HTLV-I-associated myelopathy 总被引:2,自引:0,他引:2
Kunihiko Nagasato Tatsufumi Nakamura Ohishi Kiyosumi Kohji Shibayama Masakatsu Motomura Ichinose Katsuhiro Mitsuhiro Tsujihata Shigenobu Nagataki 《Journal of neuroimmunology》1991,32(2):105-109
We investigated the presence of anti-human T-lymphotropic virus type I (HTLV-I) IgM in sera and cerebrospinal fluid from patients with HTLV-I-associated myelopathy (HAM) by Western blot analysis. Analyses of 36 serum samples revealed that most patients (31/36; 86.1%) had anti-HTLV-I IgM, whereas only four of 23 (17.4%) HTLV-I carriers had it. In studies of cerebrospinal fluid, anti-HTLV-I IgM was detected in 24 of 36 (66.7%) HAM patients, whereas none was detected in nine HTLV-I carriers. The differences were statistically significant (p less than 0.01). These results suggest that persistent active replication of HTLV-I occurs in the central nervous system as well as in the peripheral blood of HAM patients, and may contribute to the development of HAM. 相似文献
2.
J Hayakawa H Suzuki G Yoshida Y Usuda K Numata 《Masui. The Japanese journal of anesthesiology》1990,39(4):459-464
Arterial blood ketone body ratio (AKBR; acetoacetate/beta-hydroxybutyrate) is known as a parameter to indicate the function of the liver cells. We evaluated the effects of induced hypotension with prostaglandin E1 (PGE1) or trimetaphan (TMP) on AKBR in patients without liver disease undergoing mastectomy. Almost no change was observed in AKBR before, during and after hypotension with PGE1, but slight diminution was observed during hypotension with TMP. No hepatic dysfunction, however, developed in these patients postoperatively. These findings suggest that usual hypotension with TMP may provoke no postoperative hepatic dysfunction in patients without liver disease. For the patient who required either hypotension of long duration or hypotension with other factors affecting function of liver (surgical procedures, drugs and others), we prefer PGE1 to TMP as a hypotensive drug. We should also adopt PGE1 when cardiovascular control with hypotensive drug is necessary in patients with liver disease. 相似文献
3.
A Numata T Masuda T Okayasu M Hashimoto T Tanabe 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1989,37(2):350-354
A case of benign fibrous histiocytoma of the lung in a 8 years old boy was presented. He was first admitted in May, 1983, with recurrent pneumonia. Chest X-ray showed a ill-defined mass in the right lower lobe. Bronchoscopy revealed a round tumor, 1 cm. in maximum diameter, with complete obstruction of the Truncus Intermedius. Endoscopic resection was performed and partial obstruction of the Truncus Intermedius remained. He was re-admitted with pneumonia of the right middle lobe in March, 1986. Bronchoscopy showed severe stenosis of the Truncus Intermedius. Right middle and lower lobectomy was performed. The 4 X 4 X 3 cm tumor was located in the median of the Truncus Intermedius. Microscopically, the lesion composed of fibroblast-like cells and histiocyte-like cells. The patient's post-operative course was uneventful. He has no signs of local recurrence or metastasis. We believe, this is the first reported primary benign fibrous histiocytoma of the lung in a child in Japan. 相似文献
4.
5.
C Yajima N Sugai K Hanaoka K Numata K Yamamoto Y Kushida S Murakami H Yamamura 《Masui. The Japanese journal of anesthesiology》1990,39(7):882-889
The pharmacokinetics of pipecuronium bromide was studied in 9 male patients (ASA class 1-2, 20-65 years of age). Following a single intravenous dose of pipecuronium 0.08 mg.kg-1, plasma levels were measured by capillary gas chromatography. Plasma concentration-time curves were evaluated by fitting the data to a bi-exponential equation. The pharmacokinetic parameters of pipecuronium were compared with those of pancuronium (0.08 mg.kg-1) and vecuronium (0.08 mg.kg-1) previously obtained under the same anesthesia (66% N2O, 33% O2 and 1% halothane). With pipecuronium, following pharmacokinetic parameters were obtained; distribution half-life; T1/2 alpha = 3.9 +/- 0.7 min (mean +/- SEM), elimination half-life; T1/2 beta = 102 +/- 12 min, volume of the central compartment; V1 = 95 +/- 13 ml.kg-1, volume of distribution at steady state; Vdss = 264 +/- 41 ml.kg-1, clearance; Cl = 1.8 +/- 0.2 ml.min-1.kg-1. Microconstants of two-compartment open models (k12, k21, k10) were also calculated. Using Mann-Whitney's U-test, these parameters of pipecuronium were compared with those of pancuronium (n = 3) and vecuronium (n = 4). V1 and Vdss of pipecuronium were significantly larger than those of pancuronium (V1; 38 +/- 12 ml.kg-1 and Vdss; 120 +/- 4 ml.kg-1) (both P less than 0.10). Reflecting the larger central volume of pipecuronium, pipecuronium tended to have a larger clearance than that of pancuroniumu (Cl; 1.1 +/- 0.2 ml.min-1.kg-1).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
Yoshiharu Kikawa Akio Nakai Yosuke Shigematsu Masakatsu Sudo Kimitaka Kato Shinichi Haruki 《Pediatric nephrology (Berlin, Germany)》1990,4(4):343-344
Leukotriene B4 (LTB4) production in polymorphonuclear leucocytes (PMN) was examined in ten children with steroid-responsive nephrotic syndrome (SRNS) before, during, and after steroid administration. Comparison of LTB4 production was made in 14 children with non-inflammatory disease who were not receiving steroid therapy. No significant change was noted in PMN LTB4 biosynthesis in children with SRNS throughout any phase of the disease. Furthermore, there was no significant difference in LTB4 biosynthesis in PMN between SRNS patients before steroid therapy and patients with non-inflammatory disease. These findings suggest that inhibition of LTB4 production is not involved in the mechanism underlying steroid action in SRNS. 相似文献
7.
应用Y型迷宫研究了急性与慢性东莨菪碱和吗啡对小鼠记忆能力的影响。单剂量东莨菪碱(1mg/kgip)和吗啡(10mg/kgip)均能显著损害小鼠的短时记忆(workingmemory)。重复给药后东莨菪碱的这种作用很快消失。但吗啡每天一次,连续3次给药这种作用加强,连续5次给药这种作用反而减弱。东莨菪碱不能损害小鼠长时记忆(referencememory),而吗啡对长时记忆有损害作用。结果还提示小鼠短时记忆不受自发活动能力的影响。 相似文献
8.
9.
Gou Takeo Masakatsu Motomura Hidenori Matsuo Kiyosumi Ohishi Toshiro Yoshimura Shigenobu Nagataki Mitsuhiro Tsujihata 《Muscle & nerve》1993,16(8):840-848
We investigated the effect of the lgG from patients with myasthenia gravis (MG) on the degradation of normal rat junctional acetylcholine receptor (AChR) labeled with 125l-α-bungarotoxin (BuTx) and calculated the degradation rate (DR). The DR for the lgG from these patients was significantly higher than that from healthy volunteers and patients with other autoimmune diseases. For MG, DR was significantly correlated with the severity of the disease but not with anti-AChR antibody titer. DR was accelerated by lgG from patients with generalized MG whose antibody titers were in the normal range and by lgG from patients with ocular MG. These results indicate that measurement of the DR of junctional AChR in normal rats is more closely correlated with the severity of the disease than is measurement of anti-AChR antibody and that the former is a sensitive and confirmatory method for evaluating MG. © 1993 John Wiley & Sons, Inc. 相似文献
10.
The FI (partially frozen injectate) system, a new closed-system devised by the authors for thermodilution cardiac output determinations, has two major features: 1) it needs no ice-filled receptacle to keep injectate cold because it uses partially frozen injectate, and 2) it can go without monitoring the injectate temperatures during the whole process of cardiac output determinations. The author evaluated the accuracy and reproducibility of cardiac output determinations with the FI system in 10 critically ill patients, as compared with another closed-system (which is commercially available) and the standard open method. The injectate temperatures in the FI system were also measured in vitro. The mean injectate temperature in the FI system was 0.71 ± 0.26°C and 80% of the injectate temperatures were lower than 1.0°C. Even when no monitoring of injectate temperatures was made, the predicated error in the calculated cardiac output resulted as low as 2% with the FI system. The mean cardiac output values were not statistically different between the FI system and the other two systems.(Maruta H, Usuda Y, Okutsu Y et al.: A new closed-system using partially frozen injectate for thermodilution cardiac output determinations. J Anesth 3: 35–39, 1989) 相似文献