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排序方式: 共有559条查询结果,搜索用时 15 毫秒
1.
Julie Despres Yasmina Ramdani Marine di Giovanni Magalie Bnard Abderrakib Zahid Mait Montero‐Hadjadje Florent Yvergnaux Thibaut Saguet Azeddine Driouich Marie‐Laure Follet‐Gueye 《Experimental dermatology》2019,28(8):922-932
It is well recognized that the world population is ageing rapidly. Therefore, it is important to understand ageing processes at the cellular and molecular levels to predict the onset of age‐related diseases and prevent them. Recent research has focused on the identification of ageing biomarkers, including those associated with the properties of the Golgi apparatus. In this context, Golgi‐mediated glycosylation of proteins has been well characterized. Additionally, other studies show that the secretion of many compounds, including pro‐inflammatory cytokines and extracellular matrix–degrading enzymes, is modified during ageing, resulting in physical and functional skin degradation. Since the Golgi apparatus is a central organelle of the secretory pathway, we investigated its structural organization in senescent primary human dermal fibroblasts using confocal and electron microscopy. In addition, we monitored the expression of Golgi‐related genes in the same cells. Our data showed a marked alteration in the Golgi morphology during replicative senescence. In contrast to its small and compact structure in non‐senescent cells, the Golgi apparatus exhibited a large and expanded morphology in senescent fibroblasts. Our data also demonstrated that the expression of many genes related to Golgi structural integrity and function was significantly modified in senescent cells, suggesting a relationship between Golgi apparatus function and ageing. 相似文献
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Dana L. McMakin Emily J. Ricketts Erika E. Forbes Jennifer S. Silk Cecile D. Ladouceur Greg J. Siegle 《Journal of clinical child and adolescent psychology》2019,48(2):S284-S297
Sleep disturbance is prevalent in anxious youth and prospectively predicts poor emotional adjustment in adolescence. Study 1 examined whether anxiety treatment improves subjective and objective sleep disturbance in anxious youth. Study 2 examined whether a sleep intervention called Sleeping TIGERS can further improve sleep following anxiety treatment. Study 1 examined 133 youth (ages 9–14; 56% female; 11% ethnic/racial minority) with generalized, social, or separation anxiety over the course of anxiety treatment (cognitive behavioral treatment or client-centered treatment). Sleep-related problems (parent-, child-report) and subjective (diary) and objective (actigraphy) sleep patterns were assessed across treatment in an open trial design. Study 2 included 50 youth (ages 9–14; 68% female; 10% ethnic/racial minority) who continued to report sleep-related problems after anxiety treatment and enrolled in an open trial of Sleeping TIGERS. Pre- and postassessments duplicated Study 1 and included the Focal Interview of Sleep to assess sleep disturbance. Study 1 demonstrated small reductions in sleep problems and improvements in subjective sleep patterns (diary) across anxiety treatment, but outcomes were not deemed clinically significant, and 75% of youth stayed above clinical cutoff. Study 2 showed clinically significant, large reductions in sleep problems and small changes in some subjective sleep patterns (diary). Anxiety treatment improves, but does not resolve, sleep disturbance in peri-pubertal youth, which may portend risk for poor emotional adjustment and mental health. The open trial provides preliminary support that Sleeping TIGERS can improve sleep in anxious youth to a clinically significant degree. 相似文献
3.
Anne-christine Jauneau Alexander Ischenko Alexandra Chatagner Magalie Benard Philippe Chan Marie-therese Schouft Christine Patte Hubert Vaudry Marc Fontaine 《Journal of neuroinflammation》2006,3(1):8-10
C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological
activities through interaction with two G protein-coupled receptors named C3aR and C5aR, respectively. In the brain, these
receptors are expressed on glial cells, and some recent data have suggested that anaphylatoxins could mediate neuroprotection.
In this study, we used RT-PCR and ribonuclease protection assays (RPA) to investigate the role of anaphylatoxins on neurotrophin
expression by the human glioblastoma cell line T98G and by rat astrocytes. Our data show that for both cell types, anaphylatoxins
upregulate expression of NGF mRNA. This response depended on a G protein-coupled pathway since pre-treatment of cells with
pertussis toxin (PTX) completely blocked NGF mRNA increases. This effect was anaphylatoxin-specific since pre-incubation with
anti-C3a or anti-C5aR antibodies abolished the effects of C3a and C5a, respectively. The regulation of NGF mRNA by anaphylatoxins
was not accompanied by translation into protein expression, but there was a significant synergic effect of anaphylatoxins/IL-1b
costimulation. Our demonstration of involvement of anaphylatoxins in the NGF release process by astrocytes suggests that C3a
and C5a could modulate neuronal survival in the CNS. 相似文献
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5.
Robert Ladouceur Francine Ferland Frank Vitaro 《The journal of primary prevention》2004,25(3):329-335
Research on gambling demonstrates that youths are involved in gambling activities. As they take part in these activities, young people develop and maintain irrational thoughts about gambling and become at risk for developing severe gambling problems. In a previous study, a French video was designed specifically to correct misconceptions and increase knowledge about gambling (Ferland, Ladouceur, & Vitaro, 2002). Findings indicated that the video significantly improves subjects' knowledge about gambling and corrects their misconceptions. The present study aims to evaluate the effectiveness of the English version of that video. The sample comprised 506 grade 7 and 8 English speaking students from Canada. The results confirmed the efficacy of the video in increasing knowledge of gambling and correcting misconceptions concerning the outcome of these games. The implications of these results for the prevention of gambling problems are discussed. 相似文献
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