全文获取类型
收费全文 | 1924篇 |
免费 | 126篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 49篇 |
妇产科学 | 112篇 |
基础医学 | 249篇 |
口腔科学 | 68篇 |
临床医学 | 146篇 |
内科学 | 494篇 |
皮肤病学 | 72篇 |
神经病学 | 137篇 |
特种医学 | 35篇 |
外科学 | 208篇 |
综合类 | 4篇 |
预防医学 | 98篇 |
眼科学 | 31篇 |
药学 | 125篇 |
中国医学 | 1篇 |
肿瘤学 | 187篇 |
出版年
2023年 | 19篇 |
2022年 | 49篇 |
2021年 | 72篇 |
2020年 | 53篇 |
2019年 | 66篇 |
2018年 | 81篇 |
2017年 | 63篇 |
2016年 | 52篇 |
2015年 | 54篇 |
2014年 | 90篇 |
2013年 | 108篇 |
2012年 | 134篇 |
2011年 | 136篇 |
2010年 | 70篇 |
2009年 | 59篇 |
2008年 | 115篇 |
2007年 | 111篇 |
2006年 | 96篇 |
2005年 | 88篇 |
2004年 | 82篇 |
2003年 | 94篇 |
2002年 | 74篇 |
2001年 | 29篇 |
2000年 | 30篇 |
1999年 | 32篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 24篇 |
1995年 | 9篇 |
1994年 | 11篇 |
1993年 | 15篇 |
1992年 | 26篇 |
1991年 | 9篇 |
1990年 | 16篇 |
1989年 | 7篇 |
1988年 | 10篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1975年 | 2篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有2069条查询结果,搜索用时 15 毫秒
1.
Exhaled nitric oxide in children with allergic rhinitis: A potential biomarker of asthma development
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
4.
5.
A L Shapiro F G Shechtman R A Guida C P Kimmelman 《Otolaryngology--head and neck surgery》1992,106(3):258-260
A marked increase has recently been noted in the incidence of lymphoma in patients with AIDS. These lymphomas are generally high-grade, of B-cell origin, and often involve extranodal sites. Reported here are twenty patients with AIDS in whom symptoms and physical findings developed related to the head and neck region as a result of lymphoma. The tumor was observed in a variety of sites, including the nasopharynx, orbit, submandibular triangle, anterior and posterior cervical triangles, supraclavicular fossa, and the hypopharynx. Sixteen tumors were large cell nonHodgkin's B-cell lymphomas, three were small cell nonHodgkin's B-cell lymphomas, and one was Hodgkin's disease, mixed cellularity. All were treated with combination chemotherapy. A high degree of suspicion for lymphoma is required in treating any patient with AIDS who has a rapidly enlarging mass in the head and neck. If needle aspiration is nondiagnostic, excisional biopsy should be performed after a complete head and neck evaluation. Although the development of lymphoma associated with AIDS portends a grave prognosis, prompt diagnosis will allow an improved chance of remission of the lymphoma. 相似文献
6.
Maddalena Castellani Pastoris Dr. Biol. Elisabeta Volpi P. Benedetti M.D. D. Greco M.D. N. Billo M.D. MPH Prof. F. J. Fehrenbach M.D. Ingeburg Horbach M.D. P. Hohl M.D. Prof. G. Wewalka M.D. 《Infection》1992,20(2):73-77
Summary The detection of travel-associated legionellosis can be extremely difficult; hence, an extensive case investigation is recommended in pneumonia-striken travellers and tourists, who are particularly at risk of acquiring the disease. On the Island of Ischia (Isola d'Ischia, Naples, Italy) a total of six cases of Legionnaires' disease occurred from 1986 to 1990. All patients (one man and two women from Germany, one Austrian woman, one Swiss man, and one Italian woman) had taken thermal baths and stayed in local hotels; they all experienced severe pneumonia, and three of them died. These cases were associated with hotels, and the hot-water supply was presumed to have transmitted the infection. Remedial procedures were applied to the hot-water plumbing of the hotels according to the WHO recommendations and were proved to be effective. The occurrences described in this paper stress the importance of rapid and accurate reporting of diagnosed cases to the country where the infection was probably acquired, in order to ensure early detection of endemic foci and emerging clusters of legionellosis.
Sechs Fälle von reiseassoziierter Legionärskrankheit in Ischia unter Beteiligung von vier Ländern
Zusammenfassung Der Nachweis reiseassoziierter Legionärskrankheit gestaltet sich häufig schwierig. Eine Überwachung von Touristen und Reisenden, die ein erhöhtes Legionellose-Risiko haben, ist daher zu empfehlen. Zwischen 1986 und 1990 traten auf der Insel Ischia (Neapel, Italien) insgesamt sechs Fälle von Legionärskrankheit auf. Alle Patienten (ein Mann und zwei Frauen aus Deutschland, eine Österreicherin, ein Schweizer und eine Italienerin), die in Hotels auf der Insel wohnten, hatten Thermalbäder besucht. Sie erkrankten an schweren Pneumonien, wobei drei Todesfälle auftraten. Die Ansteckungsquelle konnte mit Hotels in Verbindung gebracht werden, wobei die Übertragung der Infektion über die Warmwasserleitungsnetze als gesichert anzunehmen war. Desinfektionsmaßnahmen in den betreffenden Hotels, die nach den Empfehlungen der WHO ausgeführt wurden, erwiesen sich als wirksam. Das genannte Infektionsgeschehen weist auf die Notwendigkeit hin, Fälle von Legionärskrankheit so rasch wie möglich dem Ursprungsland unter Angabe der vermuteten Infektionsquelle zu melden, um sicherzustellen, daß eine Früherkennung endemischer Herde bzw. assoziierter Legionellosen bekannt gemacht wird.相似文献
7.
The paper presents the reasoning mechanism of COR, a knowledge-based system (KBS) able to provide support for the diagnosis of coronaric ischemia by integrating the interpretation of chest pain, 12-lead ECG, and bio-marker concentrations. Chest pain features are collected interactively through a questionnaire. The ECG signal is acquired in SCP format. Any set of bio-markers can be considered. Data input is incremental and possibly incomplete. Reasoning is based on revised uncertainty calculus, which allows a formal treatment of verbally expressed uncertainty concerning both input data and diagnostic rules. Each diagnosis is supplemented by a linguistic label, expressing the plausibility of the disease identified, given the symptoms observed. 相似文献
8.
9.
Identification of a Promiscuous T-Cell Epitope in Mycobacterium tuberculosis Mce Proteins 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Maddalena Panigada Tiziana Sturniolo Giorgio Besozzi Maria Giovanna Boccieri Francesco Sinigaglia Giuliana Gialdroni Grassi Fabio Grassi 《Infection and immunity》2002,70(1):79-85
The characterization of Mycobacterium tuberculosis antigens inducing CD4(+) T-cell responses could critically contribute to the development of subunit vaccines for M. tuberculosis. Here we performed computational analysis by using T-cell epitope prediction software (known as TEPITOPE) to predict promiscuous HLA-DR ligands in the products of the mce genes of M. tuberculosis. The analysis of the proliferative responses of CD4(+) T cells from patients with pulmonary tuberculosis to selected peptides displaying promiscuous binding to HLA-DR in vitro led us to the identification of a peptide that induced proliferation of CD4(+) cells from 50% of the tested subjects. This study demonstrates that a systematic computational approach can be used to identify T-cell epitopes in proteins expressed by an intracellular pathogen. 相似文献
10.
Neuroendocrine cell markers for pancreatic islets and tumors. 总被引:1,自引:0,他引:1
Guida Maria Portela-Gomes Gerhard W Hacker Raimund Weitgasser 《Applied immunohistochemistry & molecular morphology》2004,12(3):183-192
The authors review the application of a variety of neuroendocrine cell markers to identify pancreatic islet cells and tumors. In the past, several empiric histochemical techniques had been used to demonstrate neuroendocrine cells, particularly the Grimelius argyrophilic stain. The development of immunohistochemistry made it possible to demonstrate specific cell products such as regulatory peptides, thus allowing the classification of pancreatic neuroendocrine tumors with a view to clinical symptoms. However, it is not always possible to visualize regulatory peptides in these tumors. It is therefore important to use broad-spectrum neuroendocrine cell markers to identify the neuroendocrine nature. These markers are proteins localized in the secretory granules (core- or membrane-related), in the cytosol, or in the cellular membrane. The markers most commonly used in routine histopathology are the secretory granule proteins chromogranin A and synaptophysin and the cytosolic enzyme neuronspecific enolase. Other new markers (e.g., synaptic vesicle protein 2) are of general diagnostic value. Region-specific antibodies to chromogranin A can be valuable in differentiating between benign and malignant neuroendocrine tumors. Some markers may be related to the functioning characteristics of pancreatic neuroendocrine tumors, such as prohormone convertases. In addition, markers giving further complementary information have been identified, such as five somatostatin receptor subtypes, the expression of which varies markedly in pancreatic neuroendocrine tumors. Antibodies against all somatostatin receptor subtypes are now commercially available, and immunohistochemical investigation of its expression should be routinely applied when considering treatment with somatostatin analogs. 相似文献