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Usefulness of left ventricular strain analysis in patients with takotsubo syndrome during acute phase 下载免费PDF全文
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Central Line Associated Blood Stream Infections in Pediatric Hematology/Oncology Patients With Different Types of Central Lines 下载免费PDF全文
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Emadi S Clay D Desterke C Guerton B Maquarre E Charpentier A Jasmin C Le Bousse-Kerdilès MC;French INSERM Research Network on MMM 《Blood》2005,105(2):464-473
Myeloproliferation, myelofibrosis, and neoangiogenesis are the 3 major intrinsic pathophysiologic features of myeloid metaplasia with myelofibrosis (MMM). The myeloproliferation is characterized by an increased number of circulating CD34+ progenitors with the prominent amplification of dystrophic megakaryocytic (MK) cells and myeloid metaplasia in the spleen and liver. The various biologic activities of interleukin 8 (IL-8) in hematopoietic progenitor proliferation and mobilization as well as in neoangiogenesis prompted us to analyze its potential role in MMM. We showed that the level of IL-8 chemokine is significantly increased in the serum of patients and that various hematopoietic cells, including platelets, participate in its production. In vitro inhibition of autocrine IL-8 expressed by CD34+ cells with either a neutralizing or an antisense anti-IL-8 treatment increases the proliferation of MMM CD34(+)-derived cells and stimulates their MK differentiation. Moreover, addition of neutralizing anti-IL-8 receptor (CXC chemokine receptor 1 [CXCR1] or 2 [CXCR2]) antibodies to MMM CD34+ cells cultured under MK liquid culture conditions increases the proliferation and differentiation of MMM CD41+ MK cells and restores their polyploidization. Our results suggest that IL-8 and its receptors participate in the altered MK growth that features MMM and open new therapeutic prospects for this still incurable disease. 相似文献
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Chieh-Ju Chao MD Patrick A. DeValeria MD Ayan Sen MD M.Sc Hong Lee MD Dawn M Pedrotty MD PhD Bhavesh Patel MD RDMS Reza Arsanjani MD Tasneem Z. Naqvi MD FRCP MMM 《Echocardiography (Mount Kisco, N.Y.)》2020,37(9):1465-1469
A previously healthy 49-year-old male patient presented with COVID-19 infection and required mechanical ventilation and extracorporeal membrane oxygenation due to severe hypoxemia. Echocardiography showed cardiac dysfunction with an apical sparing strain pattern, which rapidly normalized within a week. Apical sparing myocardial strain in patients with COVID-19 infection may suggest reverse-type stress cardiomyopathy. 相似文献
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Hysterosalpingo‐Contrast Sonography With a Saline‐Air Device Is Equivalent to Hysterosalpingography Only in the Presence of Tubal Patency 下载免费PDF全文
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Sevdenur Cizginer MD MPH Eian G. Prohl MD Joao Filipe G. Monteiro PhD Ferhat Yildiz MD Richard N. Jones ScD Steven Schechter MD Robert Patterson MD Adam Klipfel MD Mark Richard Katlic MD MMM Lori A. Daiello PharmD ScM Nadia Mujahid MD Iva Neupane MD William G. Cioffi MD Maria Ducharme DNP RN Matthew D. Vrees MD Lynn McNicoll MD 《Journal of the American Geriatrics Society》2023,71(5):1452-1461