全文获取类型
收费全文 | 9765篇 |
免费 | 902篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 375篇 |
妇产科学 | 172篇 |
基础医学 | 1214篇 |
口腔科学 | 184篇 |
临床医学 | 1068篇 |
内科学 | 1984篇 |
皮肤病学 | 128篇 |
神经病学 | 684篇 |
特种医学 | 614篇 |
外科学 | 1686篇 |
综合类 | 224篇 |
一般理论 | 26篇 |
预防医学 | 913篇 |
眼科学 | 88篇 |
药学 | 643篇 |
1篇 | |
中国医学 | 52篇 |
肿瘤学 | 594篇 |
出版年
2023年 | 56篇 |
2022年 | 62篇 |
2021年 | 138篇 |
2020年 | 125篇 |
2019年 | 182篇 |
2018年 | 218篇 |
2017年 | 164篇 |
2016年 | 183篇 |
2015年 | 181篇 |
2014年 | 259篇 |
2013年 | 390篇 |
2012年 | 537篇 |
2011年 | 518篇 |
2010年 | 312篇 |
2009年 | 337篇 |
2008年 | 502篇 |
2007年 | 478篇 |
2006年 | 436篇 |
2005年 | 466篇 |
2004年 | 407篇 |
2003年 | 356篇 |
2002年 | 338篇 |
2001年 | 256篇 |
2000年 | 277篇 |
1999年 | 233篇 |
1998年 | 187篇 |
1997年 | 193篇 |
1996年 | 204篇 |
1995年 | 146篇 |
1994年 | 163篇 |
1993年 | 167篇 |
1992年 | 141篇 |
1991年 | 169篇 |
1990年 | 122篇 |
1989年 | 147篇 |
1988年 | 161篇 |
1987年 | 171篇 |
1986年 | 156篇 |
1985年 | 138篇 |
1984年 | 85篇 |
1983年 | 74篇 |
1982年 | 61篇 |
1981年 | 72篇 |
1980年 | 67篇 |
1979年 | 76篇 |
1978年 | 54篇 |
1977年 | 76篇 |
1976年 | 57篇 |
1975年 | 47篇 |
1974年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 156 毫秒
1.
2.
3.
Regina K. Rowe David M. Pyle J. David Farrar Michelle A. Gill 《European journal of immunology》2020,50(10):1550-1559
Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE-mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion, phagocytosis, and influenza-induced Th1 development. In this study, we investigate the effects of IgE-mediated stimulation on monocyte-driven, RV-induced T cell development utilizing primary human monocyte-T cell co-cultures. We demonstrate that IgE crosslinking of RV-exposed monocytes enhances monocyte-driven Th2 differentiation. This increase in RV-induced Th2 development was regulated by IgE-mediated inhibition of virus-induced type I IFN and induction of IL-10. These findings suggest an additional mechanism by which two clinically significant risk factors for allergic disease exacerbations—IgE-mediated stimulation and rhinovirus infection—may synergistically promote Th2 differentiation and allergic inflammation. 相似文献
4.
5.
James R. Gill 《Forensic science, medicine, and pathology》2006,2(1):29-32
On September 11, 2001 two hijacked airplanes struck the Twin Towers at the World Trade Center in New York City. All of the
remains (19,915) were examined by the Office of Chief Medical Examiner (OCME) of New York City. The major goals of the OCME
were to accurately identify the decedents and to promptly issue death certificates. As of September 2005, there were 1594
identifications of a total of 2749 people reported missing. Of these, 976 were identified by a single means, which included
DNA analysis in 852 of the victims. Use of legal statues can assist in the timely issuance of death certificates in mass fatalities,
which benefit surviving family members. DNA analysis markedly improves the ability to identify remains and has become the
standard method for identification in these types of disasters. Certain postmortem tissue samples are better suited for DNA
analysis and yield better results than others. 相似文献
6.
7.
8.
Birth weight on 12,644 singleton infants from 6,196 sibships born in Maryland between 1980 and 1984 were used to estimate the effects of nine maternal and infant covariates on the sibship correlation in birth weight. Assuming a homogeneous correlation across all families, the estimated intraclass correlation was 0.4664 (+/- 0.0099). This high sibship correlation makes it possible to predict, with reasonable accuracy, the birth weight of a child given information on previous sibs, as well as covariates on the mother and/or infant pertinent to a given pregnancy. The reduction in variance associated with incorporating information on the nine covariates used here was approximately equal to that obtained by conditioning on a single previous sib. Testing for heterogeneity in correlation among different groups of families showed that a crude measure of parity (first live birth vs. other), time between births, mother's marital status, and maternal age at the birth of the last child significantly influenced the sibship correlation in birth weight. 相似文献
9.
D. L. Crosby G. A. Rees J. Gill 《Annals of the Royal College of Surgeons of England》1990,72(5):309-312
The current experience of a high dependency unit established 5 years ago for the postoperative care of high-risk patients undergoing surgery is reported. The resource implications and contributions to the safety and quality of post-operative care, particularly pain relief, are described. 相似文献
10.
ME BURGE AM JOSHUA CM McNEIL R HUI MJ BOYER R ABRAHAM 《Asia-Pacific Journal of Clinical Oncology》2005,1(1):47-52
Background: Pemetrexed and cisplatin have recently been shown to significantly improve survival compared with cisplatin alone. However, there are only limited data reflecting teaching hospital experience outside a clinical trial. Pemetrexed has only been available in Australia on a restricted basis since 2002. We reviewed our experience of patients treated on the Australian ‘Special Access Scheme’ at three major thoracic oncology units. Methods: Charts were reviewed for all patients enrolled on the scheme. Data was extracted on age, World Health Organization (WHO) performance status, histology, prior therapy, time from diagnosis to starting pemetrexed, chemotherapy (pemetrexed alone or with a platinum), cycle number, response rate, actuarial progression‐free and overall survival. Doses were cisplatin 75 mg/m2 or carboplatin AUC = 5 and pemetrexed 500 mg/m2 every 21 days. Results: 52 patients (32 male and 20 female) were reviewed. Median age was 58 years and 88% were WHO 0–1. Histology included 54% epithelial, 17% biphasic (epithelial and sarcomatoid) and 21% undefined. The median time from diagnosis to administration of pemetrexed was 145 days. Sixty‐five percent had minimal surgical intervention with video assisted thoracoscopy, pleurodesis and biopsy, while 19% had received prior palliative radiation. Seventy‐one percent were chemotherapy naïve, the remaining 29% having received previous platinum and/or gemcitabine regimens. Twenty‐three percent had pemetrexed alone, 35% in combination with carboplatin and 42% with cisplatin. The median number of cycles was 4 (range 1–13). The response rate was 33%. No toxicity was observed in 20% grade 3–4 toxicity in 10% (majority nausea/vomiting). The median progression‐free and overall survival times from starting pemetrexed were 184 days and 298 days, respectively. Conclusions: Pemetrexed‐based regimens are safe and effective in a community setting in malignant mesothelioma. 相似文献