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Fidel Rubagumya MD MMed MPH Adam Fundytus MD MPH Sophie Keith-Brown Wilma M. Hopman MSc Bishal Gyawali MD PhD Deborah Mukherji MD Nazik Hammad MBBS M.Sc MEHP CS Pramesh MS Ajay Aggarwal MD MSc PhD Alexandru Eniu MD Manju Sengar MBBS Rachel S. R. Riechelmann MD Richard Sullivan MD Christopher M. Booth MD 《Cancer》2023,129(18):2856-2863
Background
Oncology randomized controlled trials (RCTs) are increasingly global in scope. Whether authorship is equitably shared between investigators from high-income countries (HIC) and low-middle/upper-middle incomes countries (LMIC/UMIC) is not well described. The authors conducted this study to understand the allocation of authorship and patient enrollment across all oncology RCTs conducted globally.Methods
A cross-sectional retrospective cohort study of phase 3 RCTs (published 2014–2017) that were led by investigators in HIC and recruited patients in LMIC/UMIC.Findings
During 2014–2017, 694 oncology RCTs were published; 636 (92%) were led by investigators from HIC. Among these HIC-led trials, 186 (29%) enrolled patients in LMIC/UMIC. One-third (33%, 62 of 186) of RCTs had no authors from LMIC/UMIC. Forty percent (74 of 186) of RCTs reported patient enrollment by country; in 50% (37 of 74) of these trials, LMIC/UMIC contributed <15% of patients. The relationship between enrollment and authorship proportion is very strong and is comparable between LMIC/UMIC and HIC (Spearman’s ρ LMIC/UMIC 0.824, p < .001; HIC 0.823, p < .001). Among the 74 trials that report country enrollment, 34% (25 of 74) have no authors from LMIC/UMIC.Conclusions
Among trials that enroll patients in HIC and LMIC/UMIC, authorship appears to be proportional to patient enrollment. This finding is limited by the fact that more than half of RCTs do not report enrollment by country. Moreover, there are important outliers as a significant proportion of RCTs had no authors from LMIC/UMIC despite enrolling patients in these countries. The findings in this study reflect a complex global RCT ecosystem that still underserves cancer control outside high-income settings. 相似文献2.
Irene W. Y. Ma MD PhD RDMS RDCS Peter Steinmetz MD CCFP Kirstin Weerdenburg MD Michael Y. Woo MD Paul Olszynski MD MEd Claire L. Heslop MD PhD CerMedEd Stephen Miller MD CCFP MEd Gillian Sheppard MD Vijay Daniels MD MHPE Janeve Desy MD MEHP RDMS Maxime Valois MD Luke Devine MD MHPE Heather Curtis MD MSc Michael J. Romano MD Patrick Martel MD Tomislav Jelic MD Claude Topping MD Drew Thompson MD Barbara Power MD Jason Profetto BKin MD CCFP Pete Tonseth MD 《Journal of ultrasound in medicine》2020,39(7):1279-1287
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