全文获取类型
收费全文 | 230篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 13篇 |
妇产科学 | 4篇 |
基础医学 | 16篇 |
口腔科学 | 3篇 |
临床医学 | 48篇 |
内科学 | 57篇 |
皮肤病学 | 9篇 |
神经病学 | 9篇 |
特种医学 | 1篇 |
外科学 | 31篇 |
综合类 | 1篇 |
预防医学 | 19篇 |
眼科学 | 4篇 |
药学 | 18篇 |
肿瘤学 | 10篇 |
出版年
2022年 | 2篇 |
2021年 | 6篇 |
2017年 | 2篇 |
2016年 | 8篇 |
2015年 | 11篇 |
2014年 | 6篇 |
2013年 | 11篇 |
2012年 | 1篇 |
2011年 | 3篇 |
2010年 | 10篇 |
2009年 | 7篇 |
2008年 | 4篇 |
2007年 | 2篇 |
2006年 | 6篇 |
2005年 | 5篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1998年 | 7篇 |
1997年 | 13篇 |
1996年 | 18篇 |
1995年 | 6篇 |
1994年 | 10篇 |
1993年 | 6篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1959年 | 1篇 |
1958年 | 4篇 |
1957年 | 10篇 |
1956年 | 18篇 |
1955年 | 6篇 |
1954年 | 8篇 |
1950年 | 1篇 |
1937年 | 3篇 |
排序方式: 共有247条查询结果,搜索用时 31 毫秒
1.
RAFAEL BEYAR M.D. D.Sc. ARIEL ROGUIN M.D. JAAP HAMBURGER M.D. RE SAAIMAN M.D. ANTONIO L. BARTORELLI M.D. CARLO DiMARIO M.D. ANTONIO COLOMBO M.D. CHRISTIAN W. HAMM M.D. CHRISTOPHER J. WHITE M.D. J. MARCO M.D. PATRICK W. SERRUYS M.D. Ph.D. 《Journal of interventional cardiology》1997,10(4):277-286
The beStent is a new stainless steel, balloon-expandable mesh stent which has a unique serpentine design. Rotation of the unique low stress junctions upon expansion leads to orthogonal locking of the wires, maximizing radial strength and assuring zero shortening. The stent has delineating gold markers which assure precise positioning. We aim to present the initial acute results in a pilot registry for stent evaluation. Two hundred eighty-four stents were used in a total of 217 patients (age 57.9 ± 3.10 years; 178 males; 39 females) in seven centers, for variable indications. Stents of 15-, 25-, and 35-mm length were used. The arteries treated were the left anterior descending (n = 112, 42%), circumflex (n = 54, 20.2%), right coronary (n = 95, 35.5%), left main (n = 1, 0.4%), and vein graft (n = 5, 1.9%). Lesion types were: A in 42 patients (16.5%); B1 in 53 patients (20.7%); B2 in 81 patients (31.8%); and C in 79 patients (31%). One hundred fifty-nine patients required one stent, 40 patients required two stents, and 18 patients required three or more stents. Anticoagulation protocol included procedural heparin with aspirin with/without ticlopidine. Smooth angiographie results were obtained in all cases with no plaque herniation. Acute angiographic success was obtained in 97% of the patients, and acute clinical success in 95% of the patients. Complications within 30 days were: 3 deaths (1.4%) (2 noncardiac); 2 (0.9%) myocardial infarctions; and 2 (0.9%) stent thromboses. Therefore, the beStent is useful in treatment of complex lesions of variable length and complexity, providing excellent acute results with a low complication rate, in spite of unfavorable basic clinical and angiographie characteristics. 相似文献
2.
PIERLUIGI TABACCHI MARIELLA CHIRICOLO MARINELLA CENCI FRANCESCO BARBONI MARCO MANFRINI GAETANO BACCI PIERO PICCI MARIO CAMPANACCI FEDERICO LICASTRO CLAUDIO FRANCECHI 《Tissue antigens》1982,20(4):251-253
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B21 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population. 相似文献
3.
Synergistic effect of deoxyspergualin (DSP) and cyclosporin A (CsA) in the prevention of spontaneous autoimmune diabetes in BB rats 下载免费PDF全文
R DI MARCO P ZACCONE G MAGRO S GRASSO M LUNETTA W BARCELLINI V M NICOLOSI P L MERONI F NICOLETTI 《Clinical and experimental immunology》1996,105(2):338-343
Dose-dependent side effects are frequently observed with immunosuppressive drugs of potential relevance for the immunotherapy of insulin-dependent diabetes mellitus (IDDM), such as CsA and DSP. If CsA and DSP acted synergistically in vivo, their combined use would allow using each compound at lower doses than those required when each drug is given in monotherapy. Consequently, dose-dependent side effects could be reduced and the therapeutic activity maintained or even enforced. Toward this end we studied the effects of combined treatment with CsA and DSP on the course of IDDM in the diabetes-prone (DP)-BB rat. The results show that two ‘low’ doses of CsA (2mg/kg) and DSP (1mg/kg) that are clinically ineffective in suppressing IDDM development in BB rats when administered alone under a prolonged prophylactic regimen (30–105 days old), may successfully prevent, but not cure, the disease when given contemporaneously under the same experimental conditions. The combined treatment was well tolerated, and no side effects were noticed. These data suggest that the combined use of CsA and DSP may deserve consideration for its possible application in the prevention/treatment of human IDDM and other autoimmune diseases. 相似文献
4.
F. NICOLETTI† P. ZACCONE G. MAGRO‡ W. BARCELLTNI† V. CAVALLARO§ G. BELLI¶ C. COCUZZA R. Dl MARCO P. L. MERONI† 《Scandinavian journal of immunology》1994,40(5):549-556
Thymopentin (TP-5) is a synthetic pentapeptide that corresponds to the active 32–36 amino acid sequence of the thymic hormone thymopoietin, of which it retains all the immunomodulatory properties. In this study, we have evaluated the effects of long term prophylactic treatment with TP-5 on the clinical, immunological and histological parameters of the SLE-like syndrome that spontaneously occurs in MRL/lpr-lpr (MRL-lpr) mice. TP-5., administered (s. c.) to these mice at the doses of 1, 10 and 100mg/kg. was given daily, five times a week, from the 9th to the 26th weeks of life. The prophylactic treatment with TP-5 prolonged in a clear dose-dependent fashion the lifespan of MRL-lpr mice as compared with PBS-treated control mice, and the effect reached statistical significance at the doses of 10 and 100mg/kg. In parallel ex vivo studies., this chnical effect was associated with multiple profound modifications of the immune system including: (i) the reduction of the spontaneous and Con A-induced release of interleukin-4 (IL-4); (ii) the increased secretion of interferon-γ (IFN-γ) and IL-6 upon polyclonal mitogenic stimulation, and (iii) the amelioration of the defective Con A-induced lympho-proliferative response. In contrast, although the drug diminished the severity of proteinuHa in MRL-lpr mice, it neither reduced histological signs of lupus nephritis nor diminished the serum titres of antinative DNA and anti-histone autoantibodies. These results indicate that TP-5 displayed powerful immunomodulatory activities in a well known model of human SLE. 相似文献
5.
Job stress, absenteeism and coronary heart disease European cooperative study (the JACE study): Design of a multicentre prospective study 总被引:1,自引:0,他引:1
HOUTMAN IRENE; KORNITZER MARCEL; SMET PATRICK DE; KOYUNCU RAMAZAN; BACKER GUY DE; PELFRENE EDWIN; ROMON MONIQUE; BOULENGUEZ CHARLES; FERRARIO MARCO; ORIGGI GIANNI; SANS SUSANA; PEREZ INAKI; WILHELMSEN LARS; ROSENGREN ANNIKA; OLOFISACSSON SVEN; OSTERGREN PER-OLOF 《European journal of public health》1999,9(1):52-57
Background: The motives, objectives and design of a multicentreprospective study on job stress, absenteeism and coronary heartdisease in Europe (the JACE study) is presented in this paper.Some specific gaps in the reviewed literature are explicitlytapped into by the JACE study. Its objectives are i) to comparethe distributions of the Karasek job stress scales for the samebroad categories of occupations in different European countries(in males and females), ii) to study the predictive power ofthe job stress scales and the job strain model for one yearof sickness absence (in males and females) and iii) to studythe predictive power of the job stress scales and the job strainmodel for a three year incidence of coronary heart disease (Inmales only). Methods: In answering these questions, relationsare studied controlling for gender, age, level of education,company size, physical work risks and shift work, as well astraditional risk factors for CHD (i.e serum cholesterol, serumHDL cholesterol, smoking habits and blood pressure). The JACEstudy is a Biomed 1 concerted action. The JACE group consistsof eight participating centres from six countries, i.e. fromBelgium and Sweden (two centres), France, Italy, Spain, Swedenand The Netherlands (each one centre). The coordination of thegroup is in Brussels. The participating centres brought in over15, 000 European workers to test the hypotheses. 相似文献
6.
Identification of the Philadelphia (Ph-1) Chromosome 总被引:1,自引:0,他引:1
The presence of a marker G, which later converted into the Ph-1 chromosome, in a female patient with chronic myelogenous leukemia, permittedidentification of the G chromosome from which the Ph-1 originated as a member of the early replicating, G-22 pair. Submitted on May 13, 1969 Accepted on July 31, 1969 相似文献
7.
MARCO SCAGLIONE M.D. DOMENICO CAPONI M.D. MATTEO ANSELMINO M.D. Ph.D. FRANCESCA DI CLEMENTE M.D. ALESSANDRO BLANDINO M.D. FEDERICO FERRARIS M.D. PAOLO DI DONNA M.D. ELISA EBRILLE M.D. FRANCK HALIMI M.D. JEAN F. LECLERCQ M.D. COSTANZA IUNCO M.D. CARLOEUGENIO VAUDAGNA M.D. FEDERICO CESARANI M.D. FIORENZO GAITA M.D. 《Journal of cardiovascular electrophysiology》2014,25(12):1299-1305
8.
Safety Profile of a Miniaturized Insertable Cardiac Monitor: Results from Two Prospective Trials 下载免费PDF全文
SUNEET MITTAL M.D. PRASHANTHAN SANDERS M.B.B.S. Ph.D. EVGENY POKUSHALOV M.D. LUKAS DEKKER M.D. DEAN KEREIAKES M.D. EDWARD J. SCHLOSS M.D. ERIKA POULIOT M.S. NORELI FRANCO Ph.D. YAN ZHONG Ph.D. MARCO DI BACCO Pharm.D. HELMUT PÜRERFELLNER M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(12):1464-1469
9.
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease) 总被引:1,自引:0,他引:1
CARLO G. VERGANI ANGELO C. PLANCHER MASSIMO ZUIN MARCO CATTANEO CASIMIRO TRAMALONI SERGIO MACCARI PAOLA ROMA ALBERICO L. CATAPANO 《European journal of clinical investigation》1984,14(1):49-54
A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found. 相似文献
10.