全文获取类型
收费全文 | 287篇 |
免费 | 27篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 5篇 |
妇产科学 | 1篇 |
基础医学 | 51篇 |
口腔科学 | 16篇 |
临床医学 | 27篇 |
内科学 | 69篇 |
皮肤病学 | 3篇 |
神经病学 | 11篇 |
特种医学 | 1篇 |
外科学 | 12篇 |
预防医学 | 69篇 |
眼科学 | 4篇 |
药学 | 25篇 |
中国医学 | 2篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 14篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 13篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 20篇 |
2012年 | 16篇 |
2011年 | 33篇 |
2010年 | 22篇 |
2009年 | 15篇 |
2008年 | 23篇 |
2007年 | 11篇 |
2006年 | 17篇 |
2005年 | 20篇 |
2004年 | 16篇 |
2003年 | 11篇 |
2002年 | 14篇 |
2001年 | 2篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有314条查询结果,搜索用时 15 毫秒
1.
Rubens Souza de OLIVEIRA Lanna Jamile Corrêa da COSTA Fernanda Atanaena Gon?alves de ANDRADE Wilson UIEDA Luzia Fátima Alves MARTORELLI Ana Paula de Arruda Geraldes KATAOKA Elizabeth Salbé Travassos da ROSA Pedro Fernando da Costa VASCONCELOS Armando de Souza PEREIRA Ant?nio Ismael Barros do CARMO Marcus Emanuel Barroncas FERNANDES 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(6):497-503
The outbreaks of rabies in humans transmitted by Desmodus rotundus in 2004 and 2005,
in the northeast of the Brazilian State of Para, eastern Amazon basin, made this a
priority area for studies on this zoonosis. Given this, the present study provides
data on this phenomenon in an urban context, in order to assess the possible
circulation of the classic rabies virus (RABV) among bat species in Capanema, a town
in the Amazon basin. Bats were collected, in 2011, with mist nets during the wet and
dry seasons. Samples of brain tissue and blood were collected for virological and
serological survey, respectively. None of the 153 brain tissue samples analyzed
tested positive for RABV infection, but 50.34% (95% CI: 45.67-55.01%) of the serum
samples analyzed were seropositive. Artibeus planirostris was the most common
species, with a high percentage of seropositive individuals (52.46%, 95% CI: 52.31
52.60%). Statistically, equal proportions of seropositive results were obtained in
the rainy and dry seasons (c2 = 0.057, d.f. = 1, p = 0.88). Significantly
higher proportions of males (55.96%, 95% CI: 48.96-62.96%) and adults (52.37%, 95%
CI: 47.35-57.39%) were seropositive. While none of the brain tissue samples tested
positive for infection, the high proportion of seropositive specimens indicates that
RABV may be widespread in this urban area. 相似文献
2.
Postoperative analgesia: pain by choice? The influence of patient attitudes and patient education 总被引:3,自引:0,他引:3
Postoperative pain control can be unsatisfactory for a variety of reasons, including patients' attitudes towards pain treatment itself. To assess patients' expectations and their influence on postoperative analgesia, as well as the prevalence of pain following common gynaecological surgery, a prospective study was performed in 166 patients with either adbominal hysterectomy, mastectomy, laparoscopy or uterine curettage. After a first postoperative period with routine on-demand analgesia, a nurse specialised in pain treatment discussed the purposes and risks of pain treatment with the patients and cared for these patients in the second, subsequent study period. Following this discussion, 30 of 40 patients refusing analgesics in the first study period agreed to be given pain medication. In the groups with hysterectomy or mastectomy, pain control improved in the second postoperative period, even though the doses of analgesics administered were generally lower. Education of patients regarding the aims and risks of pain therapy is an essential part of pain control and can lead to an improvement of postoperative analgesia. 相似文献
3.
4.
Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii 总被引:2,自引:0,他引:2 下载免费PDF全文
Fachado A Rodriguez A Molina J Silvério JC Marino AP Pinto LM Angel SO Infante JF Traub-Cseko Y Amendoeira RR Lannes-Vieira J 《Infection and immunity》2003,71(9):5407-5411
Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine. 相似文献
5.
6.
7.
Elisa Postrach Rosa Aspalter Ulf Elbelt Michael Koller Rita Longin J?rg-Dieter Schulzke Luzia Valentini 《Journal of medical Internet research》2013,15(10)
Background
The Internet is widely available and commonly used for health information; therefore, Web-based weight loss programs could provide support to large parts of the population in self-guided weight loss. Previous studies showed that Web-based weight loss interventions can be effective, depending on the quality of the program. The most effective program tools are visual progress charts or tools for the self-monitoring of weight, diet, and exercises. KiloCoach, a commercial program currently available in German-speaking countries, incorporates these features. A previous investigation showed that the program effectively supports users in losing weight.Objective
We investigated weight loss dynamics stratified by weight loss success after 6-month use of KiloCoach. Furthermore, we analyzed possible associations between intensity of program use and weight loss. The results are intended for tailoring user recommendations for weight-loss Internet platforms.Methods
Datasets of KiloCoach users (January 1, 2008 to December 31, 2011) who actively used the platform for 6 months or more were assigned to this retrospective analysis. Users (N=479) were 42.2% men, mean age of 44.0 years (SD 11.7), with a mean body mass index (BMI) of 31.7 kg/m2 (SD 3.2). Based on the weight loss achieved after 6 months, 3 success groups were generated. The unsuccessful group lost <5%, the moderate success group lost 5%-9.9%, and the high success group lost ≥10% of their baseline body weight. At baseline, the unsuccessful (n=261, 54.5%), moderate success (n=133, 27.8%), and high success (n=85, 17.8%) groups were similar in age, weight, BMI, and gender distribution.Results
After 6 months, the unsuccessful group lost 1.2% (SD 2.4), the moderate success group lost 7.4% (SD 1.5), and the high success group lost 14.2% (SD 3.8) of their initial weight (P<.001). Multivariate regression showed that early weight loss (weeks 3-4), the total number of dietary protocols, and the total number of weight entries were independent predictors for 6-month weight reduction (all P<.001) explaining 52% of the variance in weight reduction. Sensitivity analysis by baseline carried forward method confirmed all independent predictors of 6-month weight loss and reduced the model fit by only 11%. The high success group lost weight faster and maintained weight loss more efficiently than the other groups (P<.001). Early weight loss was associated with weight maintenance after 1 year and 2 years (both P<.001). Weight dynamics did not differ between men and women over 6 months when adjusted for baseline and usage parameters (P=.91). The percentage of male long-term users was unusually high (42.2%).Conclusions
Our results suggest that early weight loss and close program adherence (ie, 5 dietary protocols per week and weekly entering of current weight), especially in the early phase of program usage, can improve weight loss outcome. 相似文献8.
Storti-Melo LM da Costa DR Souza-Neiras WC Cassiano GC Couto VS Póvoa MM Soares Ida S de Carvalho LH Arevalo-Herrera M Herrera S Rossit AR Cordeiro JA de Mattos LC Machado RL 《Acta tropica》2012,121(2):152-155
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. 相似文献
9.
10.
Juliana Cruz da Silva Henrique Ataide Mariz Laurindo Ferreira da Rocha Júnior Priscilla Stela Santana de Oliveira Andrea Tavares Dantas Angela Luzia Branco Pinto Duarte Ivan da Rocha Pitta Suely Lins Galdino Maira Galdino da Rocha Pitta 《Clinics (S?o Paulo, Brazil)》2013,68(6):766-771