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排序方式: 共有196条查询结果,搜索用时 31 毫秒
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Le TA Chen J Changchien C Peterson MR Kono Y Patton H Cohen BL Brenner D Sirlin C Loomba R;for the San Diego Integrated NAFLD Research Consortium 《Hepatology (Baltimore, Md.)》2012,56(3):922-932
Bile acid sequestrants (BAS) lower plasma low density lipoprotein levels and improve glycemic control. Colestimide, a BAS, has been claimed by computed tomography to reduce liver fat. Therefore, we examined the efficacy of colesevelam, a potent BAS, to decrease liver fat in patients with biopsy-proven nonalcoholic steatohepatitis (NASH). Liver fat was measured by a novel magnetic resonance imaging (MRI) technique, the proton-density-fat-fraction (PDFF), as well as by conventional MR spectroscopy (MRS). Fifty patients with biopsy-proven NASH were randomly assigned to either colesevelam 3.75 g/day orally or placebo for 24 weeks. The primary outcome was change in liver fat as measured by MRI-PDFF in colocalized regions of interest within each of the nine liver segments. Compared with placebo, colesevelam increased liver fat by MRI-PDFF in all nine segments of the liver with a mean difference of 5.6% (P = 0.002). We cross-validated the MRI-PDFF-determined fat content with that assessed by colocalized MRS; the latter showed a mean difference of 4.9% (P = 0.014) in liver fat between the colesevelam and the placebo arms. MRI-PDFF correlated strongly with MRS-determined hepatic fat content (r(2) = 0.96, P < 0.0001). Liver biopsy assessment of steatosis, cellular injury, and lobular inflammation did not detect any effect of treatment. Conclusion: Colesevelam increases liver fat in patients with NASH as assessed by MRI as well as MRS without significant changes seen on histology. Thus, MRI and MRS may be better than histology to detect longitudinal changes in hepatic fat in NASH. Underlying mechanisms and whether the small MR-detected increase in liver fat has clinical consequences is not known. (HEPATOLOGY 2012;56:922-932). 相似文献
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Spatial distribution of MRI‐determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease
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Saumya Jayakumar Michael S. Middleton Eric J. Lawitz Parvez S. Mantry Stephen H. Caldwell Hays Arnold Anna Mae Diehl Reem Ghalib Magdy Elkhashab Manal F. Abdelmalek Kris V. Kowdley C. Stephen Djedjos Ren Xu Ling Han G. Mani Subramanian Robert P. Myers Zachary D. Goodman Nezam H. Afdhal Rohit Loomba 《Journal of hepatology》2019,70(1):133-141
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Deep vein thrombosis may be a complication of extended length hospital stays. Immobilized patients, such as patients in the postoperative period, are at particularly high risk of developing a deep vein thrombosis, which can be associated with high levels of morbidity and mortality. Due to this, prevention of deep vein thrombosis is of great importance in the inpatient setting. Compression stockings have proven to play an important role in prophylaxis and may be used in their knee-length or thigh-length variety. Although randomized trials have studied the efficacy of both varieties in prevention of deep vein thrombosis, selection is often made without regard to evidence. This meta-analysis pools the findings of current studies comparing knee-length and thigh-length compression stockings for deep vein thrombosis prophylaxis. A fixed effects model was used for this study with a two-sided α-error less than 0.05 considered to be statistically significant. When both varieties of compression stockings are compared, thigh-length stockings offer a risk reduction in deep vein thrombosis development when compared with knee-length (odds ratio 1.197, confidence interval 0.983-1.458). This, however, is an insignificant finding. This analysis concludes that current data does not favor either thigh-length or knee-length compression stockings when it comes to prophylaxis of deep vein thrombosis. 相似文献
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Charlie C. Park Catherine Hooker Jonathan C. Hooker Emily Bass William Haufe Alexandra Schlein Yesenia Covarrubias Elhamy Heba Mark Bydder Tanya Wolfson Anthony Gamst Rohit Loomba Jeffrey Schwimmer Diego Hernando Scott B. Reeder Michael Middleton Claude B. Sirlin Gavin Hamilton 《Journal of magnetic resonance imaging : JMRI》2019,49(1):229-238
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Hooker Jonathan C. Hamilton Gavin Park Charlie C. Liao Steven Wolfson Tanya Dehkordy Soudabeh Fazeli Hong Cheng William Mamidipalli Adrija Gamst Anthony Loomba Rohit Sirlin Claude B. 《Abdominal imaging》2019,44(2):482-492
Abdominal Radiology - To determine the inter-reader agreement of magnetic resonance imaging proton density fat fraction (PDFF) and its longitudinal change in a clinical trial of adults with... 相似文献
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