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1.
M. F. Litvinova 《Bulletin of experimental biology and medicine》1996,121(6):632-634
The development of fetuses and their hearts (24th–37th week of pregnancy) in mothers with insulin-dependent diabetes mellitus
of various severity was studied by M-echocardiography, dopplerometry, and fetometry. A relationship is demonstrated between
the early formation of macrosomia and cardiomyopathy, on the one hand, and the severity of diabetes, on the other. Along with
metabolic disorders, hemodynamic disturbances in the mother-placenta-fetus system, which depend on the disease severity, play
a role in the pathogenesis of fetal cardiomyopathy.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 698–701, June, 1996 相似文献
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Litvinova SV Aristova VV Shul'govskii VV Basharova LA Terebilina NN Panchenko LF 《Bulletin of experimental biology and medicine》2001,131(1):44-46
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in the offspring of morphine-tolerant rats. This points to an imbalance in the neurotransmitter system and can serve as a diagnostic marker of endogenous opioid system pathology. 相似文献
4.
L. V. Kalyuzhnyi M. A. Gruden' S. V. Litvinova G. V. Torgovanova E. A. Shumova 《Bulletin of experimental biology and medicine》1996,121(1):60-63
In 3–6-week-old morphine-sensitive rats, in which morphine injection produced an analgetic effect, the serum titer of antimorphine
antibodies 24 h postinjection is less than half that observed in morphine-resistant animals. Administration of naloxone to
morphine-sensitive rats induces hyperalgesia and considerably raises the serum titer of antimorphine antibodies. Chronic injections
of the same dose of morphine, which cause its analgetic effect to disappear, increase the titer of antibodies in morphine-sensitive
rats 2-fold. In morphine-resistant rats naloxone produces an analgetic effect followed by its gradual decay and disappearance
in the course of chronic administration. Subsequent administration of morphine induces analgesia, raises the titer of antimorphine
antibodies, and lowers the titer of antiidiotypic antibodies.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp. 67–70, January, 1996
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences 相似文献
5.
Dietary polyamines promote the growth of azoxymethane-induced aberrant crypt foci in rat colon 总被引:1,自引:1,他引:1
We have examined whether dietary polyamines influence the formation and
initial growth of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in
rat colon. Effects of a combination of dietary polyamines at three dose
levels (putrescine: 50, 280, 740 nmol/g; spermidine: 10, 261, 763 nmol/g;
spermine: 1, 31, 91 nmol/g) in the polyamine-poor AIN-76A diet were studied
in animals in two different experimental situations: animals treated with
AOM alone and animals treated with AOM + difluoromethylornithine (DFMO), a
specific inhibitor of endogenous polyamine synthesis. In both experimental
situations, dietary polyamines enhanced the growth of ACF, expressed as the
number of large ACF (foci with three or more aberrant crypts, ACF > or =
3), whereas the formation of ACF, expressed as the number of ACF, was
apparently not altered. In animals treated with AOM alone, maximal growth
enhancing effect on ACF was nearly obtained with the median level of
dietary polyamine. In rats fed a low polyamine diet, basic AIN-76A, DFMO
reduced the growth of AOM-induced ACF by 83%. This inhibitory effect of
DFMO was counteracted by dietary polyamines in a dose- dependent manner,
and it was abolished at the highest level of polyamines. In conclusion, it
was demonstrated that dietary polyamines are able to enhance the growth of
AOM-induced ACF. Further, dietary polyamines reversed the DFMO-caused
inhibition of ACF growth, probably by compensating for the DFMO-reduced
endogenous polyamine synthesis.
相似文献
6.
E. A. Lyakhova S. A. Lyakhov L. A. Litvinova S. A. Andronati M. N. Lebedyuk V. P. Fedchuk G. A. Khorokhorina 《Pharmaceutical Chemistry Journal》2005,39(4):183-187
The dependence of the affinity of compounds to DNA on the structure of their fragments intercalating into the double helix
was studied in a series of aminoacetylhydrazones of 9-formylacridine and 9-formylanthracene. The synthesized compounds were
characterized by the intercalating properties and the ability to inhibit the polymerase chain reaction (PCR). The affinity
to DNA was found to be higher for acridine derivatives (log K
a = 7.37 – 8.04) than for anthracene derivatives (log K
a = 5.37 – 6.12). At the same time, both acridines and anthracenes showed insignificant ability to inhibit PCR. Thus, no correlation
between the affinity to DNA and the ability to inhibit DNA replication was observed for the compounds studied.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 4, pp. 16 – 20, April, 2005. 相似文献
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8.
Ryazantseva NV Novitskii VV Litvinova LS Tkachenko SB Kolobovnikova YV Zhukova OB Grigor'eva ES Suvorova EV Knutareva EN Radzivil TT Chasovskikh NY 《Bulletin of experimental biology and medicine》2007,143(4):395-398
We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and
patients with non-Hodgkin’s lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most
potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin’s lymphomas, spontaneous apoptosis
in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 4, pp. 370–373, April, 2007 相似文献
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