全文获取类型
收费全文 | 1975篇 |
免费 | 156篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 84篇 |
妇产科学 | 29篇 |
基础医学 | 283篇 |
口腔科学 | 52篇 |
临床医学 | 227篇 |
内科学 | 344篇 |
皮肤病学 | 71篇 |
神经病学 | 104篇 |
特种医学 | 119篇 |
外科学 | 345篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 134篇 |
眼科学 | 22篇 |
药学 | 117篇 |
中国医学 | 1篇 |
肿瘤学 | 134篇 |
出版年
2022年 | 15篇 |
2021年 | 22篇 |
2020年 | 18篇 |
2019年 | 18篇 |
2018年 | 35篇 |
2017年 | 22篇 |
2016年 | 41篇 |
2015年 | 38篇 |
2014年 | 44篇 |
2013年 | 77篇 |
2012年 | 72篇 |
2011年 | 54篇 |
2010年 | 45篇 |
2009年 | 45篇 |
2008年 | 51篇 |
2007年 | 79篇 |
2006年 | 61篇 |
2005年 | 64篇 |
2004年 | 59篇 |
2003年 | 57篇 |
2002年 | 47篇 |
2001年 | 45篇 |
2000年 | 49篇 |
1999年 | 69篇 |
1998年 | 53篇 |
1997年 | 37篇 |
1996年 | 46篇 |
1995年 | 45篇 |
1994年 | 26篇 |
1993年 | 24篇 |
1992年 | 46篇 |
1991年 | 38篇 |
1990年 | 41篇 |
1989年 | 48篇 |
1988年 | 58篇 |
1987年 | 45篇 |
1986年 | 41篇 |
1985年 | 34篇 |
1984年 | 30篇 |
1983年 | 36篇 |
1982年 | 21篇 |
1981年 | 21篇 |
1979年 | 25篇 |
1978年 | 22篇 |
1976年 | 21篇 |
1973年 | 15篇 |
1971年 | 17篇 |
1970年 | 19篇 |
1969年 | 16篇 |
1967年 | 17篇 |
排序方式: 共有2145条查询结果,搜索用时 171 毫秒
1.
Michael W. Manning Yi-Ju Li Dean Linder John C. Haney Yi-Hung Wu Mihai V. Podgoreanu Madhav Swaminathan Jacob N. Schroder Carmelo A. Milano Ian J. Welsby Mark Stafford-Smith Kamrouz Ghadimi 《Journal of cardiothoracic and vascular anesthesia》2021,35(5):1310-1318
- Download : Download high-res image (215KB)
- Download : Download full-size image
2.
L. Misery E. Weisshaar E. Brenaut A.W.M. Evers F. Huet S. Ständer A. Reich E. Berardesca E. Serra-Baldrich J. Wallengren D. Linder J.W. Fluhr J.C. Szepietowski H. Maibach for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):222-229
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. 相似文献
3.
4.
5.
6.
7.
8.
9.
A new approach to the analysis of tissue-implant interaction is presented using rat gluteal muscle as implantation site and using monoclonal antibodies to identify and quantify cells around the implant. The method can be used for comparative studies on biocompatibility. In this methodological investigation, pure titanium (Ti) was studied, revealing an initial response of macrophages, followed by the formation of a fibrous membrane, in which, even at 50 and 70 d, la-expressing cells and suppressor T-lymphocytes were present. 相似文献
10.
The cellulose-binding domain of the major cellobiohydrolase of Trichoderma reesei exhibits true reversibility and a high exchange rate on crystalline cellulose. 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M Linder T T Teeri 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(22):12251-12255
Cellulose-binding domains (CBDs) bind specifically to cellulose, and form distinct domains of most cellulose degrading enzymes. The CBD-mediated binding of the enzyme has a fundamental role in the hydrolysis of the solid cellulose substrate. In this work we have investigated the reversibility and kinetics of the binding of the CBD from Trichoderma reesei cellobiohydrolase I on microcrystalline cellulose. The CBD was produced in Escherichia coli, purified, and radioactively labeled by reductive alkylation with 3H. Sensitive detection of the labeled CBD allowed more detailed analysis of its behavior than has been possible before, and important novel features were resolved. Binding of the CBD was found to be temperature sensitive, with an increased affinity at lower temperatures. The interaction of the CBD with cellulose was shown to be fully reversible and the CBD could be eluted from cellulose by simple dilution. The rate of exchange measured for the CBD-cellulose interaction compares well with the hydrolysis rate of cellobiohydrolase I, which is consistent with its proposed mode of action as a processive exoglucanase. 相似文献