全文获取类型
收费全文 | 1620篇 |
免费 | 96篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 120篇 |
妇产科学 | 18篇 |
基础医学 | 156篇 |
口腔科学 | 47篇 |
临床医学 | 205篇 |
内科学 | 326篇 |
皮肤病学 | 16篇 |
神经病学 | 81篇 |
特种医学 | 235篇 |
外科学 | 212篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 98篇 |
眼科学 | 12篇 |
药学 | 52篇 |
1篇 | |
肿瘤学 | 116篇 |
出版年
2022年 | 3篇 |
2021年 | 8篇 |
2020年 | 13篇 |
2019年 | 16篇 |
2018年 | 24篇 |
2017年 | 21篇 |
2016年 | 21篇 |
2015年 | 32篇 |
2014年 | 41篇 |
2013年 | 45篇 |
2012年 | 59篇 |
2011年 | 49篇 |
2010年 | 64篇 |
2009年 | 56篇 |
2008年 | 50篇 |
2007年 | 42篇 |
2006年 | 45篇 |
2005年 | 41篇 |
2004年 | 37篇 |
2003年 | 28篇 |
2002年 | 37篇 |
2001年 | 28篇 |
2000年 | 25篇 |
1999年 | 36篇 |
1998年 | 91篇 |
1997年 | 91篇 |
1996年 | 98篇 |
1995年 | 62篇 |
1994年 | 61篇 |
1993年 | 55篇 |
1992年 | 34篇 |
1991年 | 31篇 |
1990年 | 20篇 |
1989年 | 46篇 |
1988年 | 40篇 |
1987年 | 51篇 |
1986年 | 32篇 |
1985年 | 41篇 |
1984年 | 24篇 |
1983年 | 22篇 |
1982年 | 17篇 |
1981年 | 22篇 |
1980年 | 11篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1973年 | 3篇 |
1970年 | 3篇 |
排序方式: 共有1734条查询结果,搜索用时 93 毫秒
1.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
2.
Hans Bosma Martin PJ van Boxtel Gertrudis IJM Kempen Jacques ThM van Eijk Jelle Jolles 《BMC public health》2007,7(1):179
Background
The aims of this study were to examine the extent to which higher intellectual abilities protect higher socio-economic groups from functional decline and to examine whether the contribution of intellectual abilities is independent of childhood deprivation and low birth weight and other socio-economic and developmental factors in early life. 相似文献3.
4.
5.
Previous reports in the literature have described correlation of increasing repeat length with severity of the phenotype, in Kennedy syndrome. We describe male siblings with different repeat lengths, with lack of expression of the phenotype in the sibling with the longer repeat length. The phenotype was identical to motor neurone disease. There is variability of expression in Kennedy syndrome and repeat length even in siblings cannot be taken as a conclusive indicator of severity. CAG repeat length cannot be used to predict the natural history of Kennedy disease. The diagnosis of Kennedy syndrome should be considered in male patients presenting with atypical motor neurone disease. 相似文献
6.
PJ Woll PhD MRCP R Pettengell PhD FRACP 《International journal of clinical practice》1997,51(2):111-115
SUMMARY The interferons are natural glycoproteins secreted in response to various stimuli, including viral infection. They have antiviral, antiproliferative and immunomodulatory effects on different target cell populations. Since recombinant human interferons have become available, they have been tested in a wide range of malignancies. They are well established in the treatment of hairy cell leukaemia, chronic myelogenous leukaemia and multiple myeloma. Although they have documented activity against lymphoma, melanoma, renal cell cancer and carcinoid tumours, their role in the treatment of these tumours is less clear. In the common solid tumours, such as lung cancer and colorectal cancer, the use of interferons remains experimental. Here we will summarise their practice applications in oncology, using randomised studies where available to establish their place in multi-modality treatment. We will not discuss their use as antiviral or immunomodulating agents in viral and autoimmune diseases, multiple sclerosis or after organ transplantation. 相似文献
7.
Cohen syndrome: fertility in a female patient 总被引:1,自引:0,他引:1
In this report we describe fertility in an adult female with Cohen syndrome. She gave birth to a son, now 1.5 years old, with discrete facial stigmata and slight psychomotor retardation. 相似文献
8.
D Collen L Nelles F De Cock G Lemmens T Van Coetsem E Demarsin H R Lijnen 《Thrombosis research》1992,65(3):421-438
K1K2Pu, a recombinant t-PA/u-PA chimera with increased thrombolytic potency in animal models of venous and arterial thrombosis, which consists of amino acids 1 to 3 and 87 to 274 of human tissue-type plasminogen activator (t-PA) and amino acids 138 to 411 of human single chain urokinase-type plasminogen activator (scu-PA), was produced and conditioned for use in patients. Chinese hamster ovary cells were transfected with an expression plasmid containing the K1K2Pu cDNA, high producer cell lines were selected and scaled up in 800 cm2 roller bottles, and 350 ml conditioned cell culture medium was harvested 3 to 7 times at 2 to 5 day intervals. Batches of 21 +/- 4 liter (mean +/- SD, n = 28) containing 1.8 +/- 0.6 mg/l of K1K2Pu related antigen were purified by chromatography on Copper chelate-Sepharose and immunoadsorption on an insolubilized murine monoclonal antibody (MA-1C8). Yields were 8.6 +/- 3.4 mg K1K2Pu per batch with a specific activity of 83,000 +/- 44,000 IU/mg. The final material, obtained at a concentration of approximately 0.7 mg/ml, was dialyzed against 0.3 M NaCl, 0.02 M Tris-HCl buffer, pH 7.5, containing 0.01% Tween 80 and 10 KIU/ml aprotinin. It was homogeneous on SDS-PAGE, contained 6.5 +/- 6.9 percent two chain material and the contamination with murine monoclonal antibody was less than 0.1 percent. After filtration of pools of 3 to 5 selected batches on 0.22 microns Millipore filters the material was sterile and virus free by routine screening; it was obtained at a concentration of approximately 0.5 mg/ml with a specific activity of 110,000 +/- 16,000 IU/mg (mean +/- SD, n = 3) and an endotoxin content of 0.5 to 7 units/mg. Bolus injection at a dose of 1 mg/kg in mice did not produce weight loss within 8 days. Thus, this material appears to be suitable for the investigation on a pilot scale of the pharmacokinetic and thrombolytic properties of K1K2Pu in patients with thromboembolic disease. 相似文献
9.
10.