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排序方式: 共有417条查询结果,搜索用时 15 毫秒
1.
M. M. Marchenko G. P. Kopyl’chuk I. A. Shmarakov O. V. Ketsa V. N. Kushnir 《Pharmaceutical Chemistry Journal》2006,40(6):296-297
The antitumor activity of 5-(5′,6′-benzocoumaro-3′-yl)methylaminouracil (BCMU) and its liposomal medicinal form was studied
in comparison to 5-fluorouracil (5-FU), a well-known antitumor drug widely used in oncological practice. The half-lethal dose
of BCMU is 14.8 ± 4.2 mg/kg, while the optimum effective dose of the drug is 6 mg/kg. In this dose, BCMU combines low toxicity
with significant antitumor activity, which is manifested by increased tumor growth inhibition (TGI) at a 19% increase in the
lifetime (LT) of experimental animals. The antitumor activity of the liposomal form of BCMU is quantitatively and qualitatively
superior to that of the nonmodified compound and 5-FU, which is manifested by the most pronounced TGI value and by a significant
LT increase.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 6, pp. 6–7, June, 2006. 相似文献
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The paper analyses results after investigation of free selection of families, parents myopia selected by signs and a definite minimum age of their first-order offsprings, including 108 matrimonial couples with the total number of 209 children. It was found that myopia is a hereditary sign manifesting itself in children at the age above 15 years and more in 90% of families of the first-order offsprings of the couples in whom one of the parents has this kind of refraction, and in 100% of families in whom both parents suffer from this kind of refraction. The incidence of myopic children in families in whom one or both parents have myopia ranges from 68% to 86%, and depends on the type of refraction. 相似文献
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O Kushnir Z Ben-Rafael J Shalev S Lipitz D Bider S Mashiach J Blankstein 《Human reproduction (Oxford, England)》1991,6(5):665-669
Ovarian hyperstimulation syndrome is a common and serious complication of human menopausal gonadotrophin/human chorionic gonadotrophin treatment. We evaluated the changes in the pituitary and ovarian hormone profiles and ultrasonographic follicular regression in 12 patients in whom human menopausal gonadotrophin was discontinued due to 'imminent' ovarian hyperstimulation. Following discontinuation, three distinct periods were observed: (i) days 1-2, the levels of oestradiol, testosterone and prolactin, and the total number of follicles continued to rise; (ii) days 3-6, the levels of oestradiol, testosterone and prolactin declined sharply and the total number of follicles was reduced significantly, while the large and medium sized follicles continued to increase. Levels of follicle-stimulating hormone and luteinizing hormone gradually declined to reach their lowest levels by days 5-6 and then increased. (iii) Thereafter the number of follicles and steroid output declined to early follicular phase levels. We conclude that discontinuation of human menopausal gonadotrophin and withholding human chorionic gonadotrophin in cycles with laboratory signs of 'imminent' ovarian hyperstimulation syndrome, allows regression of the ovarian ultrasonographic finding and prevents the development of clinical symptoms. However, if rescue of the cycle is attempted, human chorionic gonadotrophin should be given during the first 4 days after discontinuation of stimulation. 相似文献
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Tammar Kushnir Tatyana Knubovets Yacov Itzchak Uzi Eliav Menachem Sadeh Lubov Rapoport Edna Kott Gil Navon 《Magnetic resonance in medicine》1997,37(2):192-196
Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. 23Na NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the 23Na and 1H water signals, and the fast transverse relaxation time, T21, determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that 23Na NMR enables the quantitation of myotonic dystrophy progression. 相似文献
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The bioenergetics of paralyzed muscles of spastic paraplegic patients under functional electrical stimulation (FES) was studied in vivo using 31P NMR. The protocol included rest, 3 min of induced tetanic isometric contraction through surface electrodes and 40 min of recovery. The continuous stimulation, the force recording and the 31P NMR measurements were sampled simultaneously inside the whole body imager. Normal values were found for the phosphorous metabolite ratios at rest. During contraction, prominent changes were detected including: a) accumulation of inorganic phosphate (P) accompanied by an unusually strong signal in the phosphomonoester (PME) region, b) phosphocreatine (PCr) decline, and c) a decrease in the intracellular pH. In the following recovery period the physiological state of the muscle was monitored and quantitated by 31P NMR. No metabolic and mechanical irreversible damage was detected in the paraplegics' muscles activated by FES under our experimental conditions. 相似文献