全文获取类型
收费全文 | 4020篇 |
免费 | 177篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 105篇 |
妇产科学 | 51篇 |
基础医学 | 485篇 |
口腔科学 | 63篇 |
临床医学 | 243篇 |
内科学 | 1058篇 |
皮肤病学 | 58篇 |
神经病学 | 200篇 |
特种医学 | 210篇 |
外科学 | 930篇 |
综合类 | 12篇 |
一般理论 | 1篇 |
预防医学 | 65篇 |
眼科学 | 43篇 |
药学 | 155篇 |
中国医学 | 2篇 |
肿瘤学 | 479篇 |
出版年
2023年 | 22篇 |
2022年 | 46篇 |
2021年 | 97篇 |
2020年 | 37篇 |
2019年 | 43篇 |
2018年 | 90篇 |
2017年 | 62篇 |
2016年 | 86篇 |
2015年 | 79篇 |
2014年 | 103篇 |
2013年 | 122篇 |
2012年 | 188篇 |
2011年 | 234篇 |
2010年 | 117篇 |
2009年 | 101篇 |
2008年 | 212篇 |
2007年 | 198篇 |
2006年 | 201篇 |
2005年 | 212篇 |
2004年 | 211篇 |
2003年 | 188篇 |
2002年 | 183篇 |
2001年 | 127篇 |
2000年 | 122篇 |
1999年 | 141篇 |
1998年 | 48篇 |
1997年 | 48篇 |
1996年 | 41篇 |
1995年 | 38篇 |
1994年 | 29篇 |
1993年 | 24篇 |
1992年 | 78篇 |
1991年 | 56篇 |
1990年 | 50篇 |
1989年 | 58篇 |
1988年 | 40篇 |
1987年 | 54篇 |
1986年 | 47篇 |
1985年 | 48篇 |
1984年 | 29篇 |
1983年 | 28篇 |
1982年 | 18篇 |
1981年 | 17篇 |
1978年 | 24篇 |
1974年 | 25篇 |
1971年 | 17篇 |
1970年 | 19篇 |
1969年 | 18篇 |
1968年 | 16篇 |
1967年 | 19篇 |
排序方式: 共有4222条查询结果,搜索用时 0 毫秒
1.
2.
The ganglioside composition of human melanoma was analyzed in five sets of tumor specimens obtained directly from surgery, from the autologous tissue culture cell lines, and from the autologous cell lines grown in athymic nude mice. Total gangliosides of these 15 melanoma specimens were isolated and purified, and the amount of each component ganglioside was analyzed by thin-layer chromatography and a thin-layer chromatography scanner. The ganglioside composition of the five surgical melanoma specimens clearly exhibited different patterns from each other. Moreover, none of the autologous cultured melanomas possessed the same ganglioside composition as their original biopsied tumors. However, when these melanoma cell lines were transplanted into nude mice, the ganglioside composition was converted back to the same ganglioside pattern as in the original surgical specimens. The results support the view that changes in the ganglioside composition of melanoma during in vitro growth are caused by the culture environment rather than by selection of melanoma cells with a particular genotype. Reestablishment of the original ganglioside patterns after passage in nude mice provides clear evidence that in vivo expression of gangliosides is a conserved and stable function specified by the human melanoma cells. 相似文献
3.
4.
Sho Takahashi Hisato Homma Takehide Akiyama Shinichi Mesawa Kenichiro Hirata Katsuhisa Kogawa Kunihiro Takanashi Hirotoshi Ishiwatari Yutaka Kawano Tsuyoshi Hayashi Kohichi Takada Koji Miyanishi Junji Kato Yoshiro Niitsu 《Nihon Shokakibyo Gakkai zasshi》2007,104(8):1236-1244
A 75-year-old man had been admitted to another hospital because of left abdominal pain, and was given a diagnosis of left hydronephrosis and acute pancreatitis. After a JJ stent insertion and medication, he was transferred to our hospital for further examinations. US and EUS revealed a chronic pancreatitis-like pattern and multicystic lesion in the pancreas head and body. At that time enhanced CT findings showed an extrapancreatic low density area to be inflammatory change, extending from the pancreas body to the left crus of the diaphragm and posteriorly the spreading from the left crus of the diaphragm via the left urinary duct into the left iliopsoas muscle, in which MRI revealed partial high intensity. ERCP and MRCP showed focal irregular narrowing of the pancreatic duct of unknown cause, and we decided that an internal pancreatic fistula due to pancreatitis had induced left ureteral obstruction, caused by a protein plug or alcohol. Follow-up 6 months later showed that extrapancreatic spreading of the low density area had markedly regressed without any change in the ureteral obstruction. 相似文献
5.
Hiroshi Ujike Kazuo Tsuchida Kazufumi Akiyama Yutaka Fujiwara Shigetoshi Kuroda 《Pharmacology, biochemistry, and behavior》1995,50(4):613-617
The ontogeny of the behavioral effects of acute cocaine administration and behavioral sensitization to cocaine in rat pups was investigated. Acute behavior stimulating effects of cocaine were observed in pups as young as 7 postnatal days (PND) old, although they needed a higher dose of cocaine than adult rats to evoke the same motor effects. An adult dose-response curve pattern of stereotypy and locomotion to acute cocaine treatment was observed at PND 21, and of rearing at PND 28. Rats aged PND 7, 14, 21, 28, and 56 received repeated injections of saline or cocaine (15 mg/kg) twice a day for 5 consecutive days. After a 3-week period of abstinence, sensitization to a challenge dose of cocaine was assessed. Cocaine-induced stereotyped behavior was enhanced significantly only in rats in which cocaine pretreatment was initiated on PND 21, 28, and 56, but not earlier on PND 7 and 14. Adult female rats given repeated cocaine injections on PND 56–60 showed significantly greater sensitization than males, but no such sex difference was observed in pups given cocaine repeatedly on PND 21–25 or 28–32. These results show clearly that cocaine-induced behavioral sensitization in rats occurred only when subchronic cocaine administration was commenced on PND 21 or later. 相似文献
6.
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. 总被引:2,自引:0,他引:2
T Hibi N Shitara S Genka T Fuchinoue I Hayakawa T Tsuchida K Nomura T Kondo K Takakura 《Neurosurgery》1992,31(4):643-50; discussion 650-1
An analysis of 39 patients under 20 years of age with brain stem glioma treated with radiotherapy between 1977 and 1991 was undertaken. Twenty-eight (71.2%) of the patients responded well to initial radiotherapy, and 11 (28.8%) responded poorly. Median survival for the total patient population was 10 months. Response rates and median survivals were influenced by radiation dose: 45.5% and 9 months at doses less than 4499 cGy (n = 11), 83.3% and 13 months at doses between 4500 and 5499 cGy (n = 12), 66.7% and 11.5 months at doses between 5500 and 6499 cGy (n = 9), and 100% and 10 months at doses more than 6500 cGy (n = 7). Multivariate analysis revealed the response to initial radiotherapy was the only predictor of survival with radiation doses up to 6499 cGy. Four of the patients who responded well demonstrated radiological and/or histological calcification within or around the tumor at the time of clinical deterioration. Radiation injury was confirmed in two autopsy cases. The possibility that intratumoral radiation injury causes clinical deterioration is suggested. 相似文献
7.
8.
Plaque composition and its relationship with acknowledged shear stress patterns in coronary arteries. 总被引:2,自引:0,他引:2
9.
Kunihiro Ichinose Mitsuru Nakamura Kenji Takezawa Ichiro Masutomi Yoichi Shima Yoko Hirayama Kahoko Sorimachi Teruhiko Shimizu Hiroyo Ishikawa Namiko Kaji Sayaka Nakajima Michiko Wataru Shiho Nishigaki Hiroshi Suwa Yosuke Toyama Masaki Okumura Yoshikazu Ishitsuka Ken Shimizu Kazuya Kokubo Kenji Sasaki Shodai Saito 《Seishin shinkeigaku zasshi》2006,108(9):945-954
10.
Takao Hashimoto Osamu Sasaki Kunihiro Yoshida Yo-ichi Takei Shu-ichi Ikeda 《Movement disorders》2003,18(10):1201-1204
We report on a family with ataxia type 6 (SCA6) showing peculiar oculomotor symptoms. The proband presented with periodic alternating nystagmus (PAN), and her 2 brothers had rebound nystagmus and gaze-evoked nystagmus. They carried the identical mutation (the number of expanded CAG repeat, 24) in the CACNA1A gene. The intrafamilial variability of oculomotor symptoms may be ascribed to factors other than CAG repeat expansion size in SCA6. 相似文献