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Samiran Upadhyaya Achyut Konwar Devasish Chowdhury Neelotpal Sen Sarma 《RSC advances》2020,10(43):25408
Water-borne adhesives have immense importance in cellulose-based materials, where their durability, handling, and strength remain to be a major concern. The present work demonstrates the development of three water-borne adhesives, namely, poly(1-vinyl-2-pyrrolidone-co-acrylic acid), poly(acrylonitrile-co-acrylic acid), and poly(1-vinyl-2-pyrrolidone-co-acrylonitrile-co-acrylic acid) applicable for cellulose-based materials. These acrylic-acid based adhesives were characterized by Fourier-transform infra-red spectroscopy, thermogravimetric analysis, X-ray diffraction, gel permeation chromatography, and universal testing machine. The synthesized polymer adhesives can be stored in the powder form for a longer period, thus utilizing less space. In order to use as adhesives, suitable formulations can be prepared in water. The adhesives show thermal stability up to 300 °C. Our studies show that poly(1-vinyl-2-pyrrolidone-co-acrylonitrile-co-acrylic acid) showed higher lap shear strength (ASTM D-906) than commercially available adhesives. In addition, these adhesives, being fluorescent in nature, can be detected under UV light and thus are applicable for the detection of fractured joints of any specimen. This property also helps in anti-counterfeiting applications, thus adding further to their utility.Synthesis and application of a water-borne fluorescent acrylic adhesive, which can be stored as a powder for long-term use. 相似文献
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Salam Pradeep Singh Rocktotpal Konwarh Bolin Kumar Konwar Niranjan Karak 《Medicinal chemistry research》2013,22(5):2139-2150
Helicobacter pylori (Hp) is a human pathogen associated with myriad of diseases such as gastritis, peptic ulceration, piles and gastric cancer. The resistance of Hp against antimicrobial agents has increased just as that of other pathogens worldwide, thus emphasizing an urgent need for developing new antibacterial agents. The d-alanine:d-alanine ligase (Ddl, EC 6.3.2.4) has been considered as a putative antimicrobial drug target and a lot of inhibitor screening efforts have been made. Quercetin, a member of the flavonoids, characterized by a flavone nucleus composed of two benzene rings linked through a heterocyclic pyrone ring is reported to possess antibacterial activity against H. pylori Ddl (HpDdl) enzyme. In this milieu, we have performed molecular docking analysis of quercetin and its analogues at the active site of HpDdl. Some of the screened compounds showed better affinity and interaction with HpDdl enzyme. The docking analysis and absorption, distribution, metabolism and toxicity study forward few of them as plausible lead molecule or a novel class of drugs with enhanced pharmacological properties. 相似文献
3.
Sameeran Kumar Das Khairujjaman Laskar Dipika Konwar Aniket Sahoo Binoy K. Saikia Utpal Bora 《Sustainable Chemistry and Pharmacy》2020
A green reaction medium has been developed from the Water Extract of Teak leaf (Tectona grandis) ash (WET). The alkaline nature of the WET was successfully applied towards hydration of nitriles, conversion of arylboronic acids to phenols with 30% aqueous H2O2, Knoevenagel condensation for benzylidenemalononitrile derivatives formation and Chan-Lam reaction of arylboronic acids with imidazole derivatives. In current protocols dual role of WET as reaction medium as well as base has been explored. A wide range of substrates with varying electronic natures is compatible under these WET mediated reaction conditions with excellent yields. 相似文献
4.
Ram H Sarkar J Kumar H Konwar R Bhatt ML Mohammad S 《Journal of maxillofacial and oral surgery》2011,10(2):132-137
Introduction
Oral cancer is one of the most common cancers and it constitutes a major health problem particularly in developing countries. It is one of the leading causes of death. Tobacco and alcohol consumption appears to be the major determinants of oral cancer. 相似文献5.
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Background An extremely high prevalence of stomach cancer was observed in Mizoram (India), where the population consumes uncommon food.
The relation of food habits and stomach cancer was examined in this study.
Methods A hospital-based case-control study was conducted during 2001–2004 to determine the risk factors among 329 patients with histologically
confirmed stomach cancer and 658 matched controls. Food habits were determined by personal interview.
Results An elevated risk of stomach cancer was observed with frequent consumption of sa-um [odds ratio (OR) 3.4] (sa-um is fermented
pork fat, a traditional food) and with frequent consumption of smoked dried salted meat (OR 2.8) and fish (OR 2.5). Soda (alkali),
used as a food additive, increased the risk of stomach cancer (OR 2.9). Helicobacter pylori infection was not found to be an independent risk factor for carcinogenesis of stomach cancer in this study. However, when
H. pylori infection interacted with consumption of sa-um or smoked dried meat, it showed a significant association.
Conclusion Peculiar food habits in Mizoram might be associated with the high prevalence of stomach cancer in Mizoram along with other
factors. H. pylori infection might increase the risk of stomach cancer, or it may play a role as a promoter of stomach cancer in Mizoram. 相似文献
7.
Pooja S Francis A Bid HK Kumar S Rajender S Ramalingam K Thangaraj K Konwar R 《Breast cancer research and treatment》2011,126(3):739-747
TNF-α and -β, the multi-functional pro-inflammatory cytokines, are known to play important roles in both tumor progression
and destruction based on their concentrations. Growth factors and various stimuli such as cytokines regulate proliferation
of the breast epithelial cells. Therefore, the polymorphisms in the genes encoding these signaling molecules could affect
the risk of breast cancer. We have investigated selected genetic polymorphisms in TNF-α promoter (rs1800629, −308 G>A and
rs361525, −238 G>A) and TNF-β intron 1 (rs909253, +252 A>G) in ethnically two different case–control groups from India. The
study included 200 cases and 200 controls from an Indo-European (North Indian) group, and 265 cases and 237 controls from
a Dravidian (South Indian) group. Genotyping of a total of 902 individuals was done by direct DNA sequencing. None of the
polymorphisms showed significant association with breast cancer in the Indo-European group; however, all the three polymorphisms
showed strong association with breast cancer in the Dravidian group. Further, sub-group analysis in the Indo-European group
showed no significant difference between pre-menopausal cases and controls or between post-menopausal cases and controls at
any of the loci analyzed. However, all the polymorphisms in the Dravidian group were significantly associated with pre-menopausal
but not with post-menopausal breast cancer. In conclusion, TNF-α and -β polymorphisms are strongly associated with breast
cancer in the Dravidian but not in the Indo-European group. 相似文献
8.
New orally active DNA minor groove binding small molecule CT‐1 acts against breast cancer by targeting tumor DNA damage leading to p53‐dependent apoptosis
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Background: Inflammation is a key event closely associated with the pathophysiology of type 2 diabetes mellitus (T2DM). Association of genetic polymorphisms of inflammatory cytokines with T2DM is largely unknown. Our objective was to investigate the relationship of polymorphism of IL-1RN and IL-4, two important biomarkers of inflammation, with the risk of T2DM. Setting and Design: We recruited 120 clinically diagnosed T2DM patients and 150 normal healthy controls for this study in order to evaluate the nature of polymorphisms of IL-1RN and IL-4. Materials and Methods: Genomic DNA was isolated from the blood of all subjects, and the variable number of tandem repeat (VNTR) polymorphisms of IL-1RN and IL-4 genes was identified by polymerase chain reaction. Statistical Analysis Used: Genotype distribution and allelic frequencies were compared between patients and control group. Means, as well as odds ratios (ORs) with 95% confidence intervals (CI), were calculated using SPSS software (version 11.5). Results: Our study revealed that distribution of both IL-4 and IL-1RN (VNTR) gene polymorphisms were significantly associated with T2DM subjects. We, however, failed to find any association of gene-gene (IL-4 and IL-1RN) interaction with T2DM. Conclusions: Both IL-4 and IL-1RN (VNTR) gene polymorphisms were significantly associated with T2DM subjects. This may suggest that the genetic polymorphisms of IL-4 and IL-1RN genes could serve as susceptibility indicators for T2DM in the Indian population, but the actual mechanism of these associations will require more elaborate investigations. Lack of association of gene-gene (IL-4 and IL-1RN) interaction with T2DM may indicate the independent nature of influence of both these genes on the risk of T2DM. 相似文献