排序方式: 共有33条查询结果,搜索用时 15 毫秒
1.
2.
Anand A Sinha PA Kittappa K Mulchandani MH Debrah S Brookstein R 《The Indian journal of surgery》2011,73(1):13-18
Inguinal hernia is the commonest surgical operation. This is a large study from a district general hospital. The study spanned
over 2 years with 2 further years of follow up. It is a retrospective analysis of eight hundred and seventy seven (877)inguinal
hernia operations performed in a district general hospital. The following factors were looked at: type of repair, grade of
surgeon performing the procedure and outcome of various repairs. The results showed that the most common technique was the
Lichenstein’s repair(58%). Recurrence rates were between 0.4%–30% depending on types of hernia repair. 相似文献
3.
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
Milan Joksimovic Angela Anderegg Anil Roy Laura Campochiaro Beth Yun Raja Kittappa Ronald McKay Rajeshwar Awatramani 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(45):19185-19190
Midbrain dopamine neurons (mDA) are important regulators of diverse physiological functions, including movement, attention, and reward behaviors. Accordingly, aberrant function of dopamine neurons underlies a wide spectrum of disorders, such as Parkinson''s disease (PD), dystonia, and schizophrenia. The distinct functions of the dopamine system are carried out by neuroanatomically discrete subgroups of dopamine neurons, which differ in gene expression, axonal projections, and susceptibility in PD. The developmental underpinnings of this heterogeneity are undefined. We have recently shown that in the embryonic CNS, mDA originate from the midbrain floor plate, a ventral midline structure that is operationally defined by the expression of the molecule Shh. Here, we develop these findings to reveal that in the embryonic midbrain, the spatiotemporally dynamic Shh domain defines multiple progenitor pools. We deduce 3 distinct progenitor pools, medial, intermediate, and lateral, which contribute to different mDA clusters. The earliest progenitors to express Shh, here referred to as the medial pool, contributes neurons to the rostral linear nucleus and mDA of the ventral tegmental area/interfascicular regions, but remarkably, little to the substantia nigra pars compacta. The intermediate Shh+ progenitors give rise to neurons of all dopaminergic nuclei, including the SNpc. The last and lateral pool of Shh+ progenitors generates a cohort that populates the red nucleus, Edinger Westphal nucleus, and supraoculomotor nucleus and cap. Subsequently, these lateral Shh+ progenitors produce mDA. This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD. 相似文献
4.
Revathidevi Sundaramoorthy Manikandan Mayakannan Rao Arunagiri Kuha Deva Magendhra Vinothkumar Vilvanathan Arunkumar Ganesan Rajkumar Kottayasamy Seenivasagam Ramani Rajendran Rajaraman Ramamurthy Ajay Chandrasekar Munirajan Arasambattu Kannan 《Tumour biology》2016,37(9):11983-11990
Tumor Biology - Breast cancer and cervical cancer are the leading causes of death in women worldwide as well as in India, whilst oral cancer is the top most common cancer among Asian especially in... 相似文献
5.
6.
Kittappa Vinothkumar Ashima Kushwaha Bhardwaj Thandavarayan Ramamurthy Swapan Kumar Niyogi 《Diagnostic microbiology and infectious disease》2013
A triplex PCR assay was developed for the identification of 3 major Vibrio spp., Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio fluvialis by targeting their haemolysin, haem-utilizing, and central regulatory genes, respectively. This simple, rapid, sensitive, and specific assay using cell lysates from 227 samples established its usefulness in research and epidemiology. 相似文献
7.
The molecular characterization of the fetal stem cell marker AA4. 总被引:16,自引:0,他引:16
8.
Dhanasekaran Sihivahanan Mavishna Maniyan Vijayakumari Pradeep Kumar Yadalam Nezar Boreak Sultan Binalrimal Saeed M. Alqahtani Mohammed Hussain Dafer Al Wadei Thilla Sekar Vinothkumar Hitesh Chohan Harisha Dewan Shilpa Bhandi Shankargouda Patil 《Materials》2022,15(9)
Background: The clinical success of post-core restorations is determined by the composite utilized and the strength of the post-core adhesion. The effectiveness of titanium dioxide nanoparticles (TiO2 NPs) as a multifunctional material with photo-induced activities and better mechanical characteristics are observed as particle size is reduced to under 50 nm. Aim: The purpose of this study is to determine the bond strength of fibre-reinforced composite (FRC) posts with TiO2 NP as fillers and to compare it with conventional composite resin core material. Materials and Methods: 30 single-rooted mandibular premolars were selected and routine root canal procedures were done. A quantity of 5% TiO2 NPs were synthesized and added as silanized filler to the experimental composite resin. Post space was prepared and fibre-reinforced composite (FRC) post luting was performed. The specimens were then grouped into the following groups: Group I consisted of the experimental composite resin containing 5% TiO2 fillers, Group II consisted of core X flow, and Group III consisted of Multicore Flow. All test groups were submitted for thermocycling. After this, the samples were tested for micro tensile bond strength. A stereomicroscope with a magnification of 20× was used to examine the fractured surfaces. The data were analysed using one-way ANOVA and Tukey HSD tests. Results: Statistical analysis revealed that Group I showed the highest mean bond strength value of 35.6180 Mpa. The results obtained with Group III showed the lowest mean bond strength value of 19.4690 Mpa. Adhesive failures were identified by stereomicroscopy of the fractured surfaces. Conclusion: The experimental composite resin comprising 5% TiO2 NP had a greater bond to the FRC post than other materials tested. 相似文献
9.
Increased Intracellular Reactive Oxygen Species Mediates the Anti‐Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells
下载免费PDF全文
![点击此处可从《The Prostate》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.
Rajamanickam Vinothkumar Rajenderan Vinoth Kumar Mani Sudha Periyaswamy Viswanathan Thangavel Balasubramanian Namasivayam Nalini 《Experimental and molecular pathology》2014
Colon cancer is the third most global oncologic problem faced by medical fraternity. Troxerutin, a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables, exhibits various pharmacological and biological activities. This study was carried out to investigate the effect of troxerutin on xenobiotic metabolizing enzymes, colonic bacterial enzymes and the development of aberrant crypt foci (ACF) during 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 served as control. Group 2 received troxerutin (50 mg/kg b.w., p.o. every day) for 16 weeks. Groups 3–6 received subcutaneous injections of DMH (20 mg/kg b.w.) once a week, for the first four weeks. In addition, groups 4–6 received different doses of troxerutin (12.5, 25, 50 mg/kg b.w., p.o. every day respectively) along with DMH injections. Our results reveal that DMH treated rats exhibited elevated activities of phase I enzymes such as cytochrome P450, cytochrome b5, cytochrome P4502E1, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase and reduced activities of phase II enzymes such as glutathione-S-transferase (GST), DT-diaphorase (DTD) and uridine diphospho glucuronyl transferase (UDPGT) in the liver and colonic mucosa of control and experimental rats. Furthermore, the activities of fecal and colonic mucosal bacterial enzymes, such as β-glucronidase, β-glucosidase, β-galactosidase and mucinase were found to be significantly higher in DMH alone treated rats than those of the control rats. On supplementation with troxerutin to DMH treated rats, the alterations in the activities of the biotransforming enzymes, bacterial enzymes and the pathological changes were significantly reversed, the effect being more pronounced when troxerutin was supplemented at the dose of 25 mg/kg b.w. Thus troxerutin could be considered as a good chemopreventive agent against the formation of preneoplastic lesions in a rat model of colon carcinogenesis. 相似文献