全文获取类型
收费全文 | 9070篇 |
免费 | 690篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 338篇 |
妇产科学 | 162篇 |
基础医学 | 1003篇 |
口腔科学 | 240篇 |
临床医学 | 1795篇 |
内科学 | 1498篇 |
皮肤病学 | 71篇 |
神经病学 | 687篇 |
特种医学 | 183篇 |
外科学 | 888篇 |
综合类 | 138篇 |
一般理论 | 11篇 |
预防医学 | 1223篇 |
眼科学 | 123篇 |
药学 | 544篇 |
中国医学 | 2篇 |
肿瘤学 | 793篇 |
出版年
2023年 | 39篇 |
2022年 | 63篇 |
2021年 | 146篇 |
2020年 | 98篇 |
2019年 | 111篇 |
2018年 | 178篇 |
2017年 | 123篇 |
2016年 | 151篇 |
2015年 | 164篇 |
2014年 | 275篇 |
2013年 | 393篇 |
2012年 | 576篇 |
2011年 | 654篇 |
2010年 | 342篇 |
2009年 | 312篇 |
2008年 | 578篇 |
2007年 | 652篇 |
2006年 | 629篇 |
2005年 | 656篇 |
2004年 | 625篇 |
2003年 | 559篇 |
2002年 | 554篇 |
2001年 | 101篇 |
2000年 | 84篇 |
1999年 | 117篇 |
1998年 | 92篇 |
1997年 | 78篇 |
1996年 | 77篇 |
1995年 | 59篇 |
1994年 | 65篇 |
1993年 | 52篇 |
1992年 | 77篇 |
1991年 | 75篇 |
1990年 | 56篇 |
1989年 | 64篇 |
1988年 | 62篇 |
1987年 | 61篇 |
1986年 | 52篇 |
1985年 | 57篇 |
1984年 | 55篇 |
1983年 | 51篇 |
1982年 | 46篇 |
1981年 | 32篇 |
1980年 | 36篇 |
1979年 | 35篇 |
1978年 | 38篇 |
1976年 | 34篇 |
1974年 | 41篇 |
1973年 | 35篇 |
1972年 | 30篇 |
排序方式: 共有9772条查询结果,搜索用时 31 毫秒
1.
2.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献3.
4.
5.
6.
Kai-Hang Yiu MBBS Chung-Wah Siu MBBS Chu-Pak Lau MD Kathy L.F. Lee MBBS Hung-Fat Tse MD 《Heart rhythm》2007,4(2):221-223
We report a case of successful transvenous, catheter-based, cavotricuspid isthmus ablation for treatment of atrial flutter using microwave energy. Microwave energy was delivered at 900–930 MHz using 21 W of power. Bidirectional cavotricuspid isthmus conduction block was achieved by microwave ablation without any patient discomfort or complication during the procedure. Our initial experience suggests that transcatheter microwave ablation is feasible for the cure of typical atrial flutter. 相似文献
7.
Daniel Drake Kathy Dutton Martha Engelke Maura McAuliffe Mary Ann Rose 《Surgery for obesity and related diseases》2005,1(5):462-466
BACKGROUND: Despite increasing numbers of morbidly obese patients admitted to acute care facilities for surgery or treatment of nonsurgical conditions, there is little evidence of the problems nurses face in providing care to these patients. Anecdotal evidence suggests that the care of these patients is more demanding than the care of nonobese patients. The objective of this study was to describe nurses' perceptions of the challenges that they face when caring for morbidly obese patients. METHODS: Focus groups of nurses from a tertiary care facility were convened. A trained facilitator posed questions to the group concerning various aspects of care for morbidly obese patients. Comments of respondents were categorized using NVIVO software. RESULTS: Nurses reported concerns about the increased staffing needs required for care of these patients and the particular challenges of the physical care. Concerns also included the availability, placement, and use of specialized equipment. Room size and the absence of some equipment were also problematic. Finally, nurses perceived safety issues, both for themselves and their patients. CONCLUSIONS: Morbidly obese patients in the acute care setting require specialized nursing care in terms of techniques, levels of staffing required, and the use of specialized equipment. 相似文献
8.
9.
Marcus P Kennedy Raymond D Coakley Scott H Donaldson Robert M Aris Kathy Hohneker Joel P Wedd Michael R Knowles Peter H Gilligan James R Yankaskas 《Journal of cystic fibrosis》2007,6(4):267-273
BACKGROUND: The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown. METHODS: A six-year retrospective review of all patients with B. gladioli infection was performed in a tertiary referral center with cystic fibrosis and lung transplantation programs. In addition, a targeted survey of all 251 lung transplant recipients was performed. Available B. gladioli isolates were analyzed via pulsed field gel electrophoresis. RESULTS: Thirty-five patients were culture positive for B. gladioli, including 33 CF patients. No bacteremia was identified. Isolates were available in 18 patients and all were genetically distinct. Two-thirds of these isolates were susceptible to usual anti-pseudomonal antibiotics. After acquisition, only 40% of CF patients were chronically infected (> or =2 positive cultures separated by at least 6 months). Chronic infection was associated with resistance to > or =2 antibiotic groups on initial culture and failure of eradication after antibiotic therapy. The impact of acquisition of B. gladioli infection in chronic infection was variable. Three CF patients with chronic infection underwent lung transplantation. One post-transplant patient developed a B. gladioli mediastinal abscess, which was treated successfully. CONCLUSIONS: The majority of patients' culture positive for B. gladioli at our center have CF. B. gladioli infection is often transient and is compatible with satisfactory post-lung transplantation outcomes. 相似文献
10.