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1.
Rammurti T Kamble George B Selby Martha Mims Mohamed A Kharfan-Dabaja Howard Ozer James N George 《Biology of blood and marrow transplantation》2006,12(5):506-510
Iron overload presenting as exacerbation of hepatic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation has not been previously described. We report 6 patients with established hepatic GVHD in whom iron overload (median serum ferritin, 7231 mug/dL; median transferrin saturation, 77%) resulting from a lifetime median of 20 units of packed red blood cell transfusions was manifested by worsening of liver function. Liver biopsies performed in 4 patients confirmed severe iron overload and also hepatic GVHD. Analysis for the C282Y and H63D hemochromatosis gene mutation was negative for the homozygous state in all 6 patients. Erythropoietin-assisted phlebotomy resulted in normalization of liver function at a median of 7 months and of serum ferritin at a median of 11 months. Immunosuppressive therapy was successfully tapered in all 4 patients who completed the phlebotomy program, and this supported the impression that iron overload, rather than GVHD, was the principal cause of liver dysfunction. At a median follow-up of 50 months (range, 18-76 months) from the transplantation and 25 months (range, 5-36 months) from ferritin normalization, all 4 patients require maintenance phlebotomy. We conclude that iron overload can mimic GVHD exacerbation, thus resulting in unnecessary continuation or intensification of immunosuppressive therapy for GVHD, and that maintenance phlebotomy is necessary after successful iron-reduction therapy. 相似文献
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Barry Finkelstein DPM Ravi Kamble DPM Edward Ferdinando DPM Neville Mobarakai MD 《The Journal of foot and ankle surgery》2003,42(6):366-370
Gas-producing diabetic foot infections are limb-threatening emergencies commonly encountered by foot and ankle surgeons. Appropriate treatment includes aggressive surgical debridement, parenteral antibiotics, and postoperative wound care. The authors present a unique case of a patient who refused treatment for a deep-space gas-producing infection, resulting in autoamputation of the foot. The authors also discuss the confusion surrounding the definition of gas gangrene. 相似文献
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Bhat S Kamble RT Sundaram P Joshi JM 《The Indian journal of chest diseases & allied sciences》2002,44(3):191-194
Transdiaphragmatic extension of hydatid cyst (HC) or cystic echinococcosis (CE) of the liver is a rare phenomenon. We report a case that presented as a right middle lobe consolidation. The diagnosis of transdiaphragmatic extension of hepatic hydatid cyst was suspected on CT scan of the chest and abdomen, and confirmed operatively. A successful outcome was achieved by a combination of pre- and post-operative albendazole therapy combined with surgery. 相似文献
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Carlos A. Ramos Rayne Rouce Catherine S. Robertson Amy Reyna Neeharika Narala Gayatri Vyas Birju Mehta Huimin Zhang Olga Dakhova George Carrum Rammurti T. Kamble Adrian P. Gee Zhuyong Mei Meng-Fen Wu Hao Liu Bambi Grilley Cliona M. Rooney Helen E. Heslop Gianpietro Dotti 《Molecular therapy》2018,26(12):2727-2737
9.
Synthesis and Evaluation of New 4‐Chloro‐2‐(3‐chloro‐4‐fluorophenyl)‐5‐(aliphatic/cyclic saturated amino)pyridazin‐3(2H)‐one Derivatives as Anticancer,Antiangiogenic, and Antioxidant Agents 下载免费PDF全文
10.
V. V. Burungale Hyojung Bae A. S. Kamble J.-H. Kim P. S. Patil J.-S. Ha 《RSC advances》2020,10(48):28492
Carbon doping from a Ti precursor in TiO2 synthesized by a hydrothermal method was studied. The structural, optical and morphological study of the deposited material was carried out using X-ray diffraction, UV-vis spectroscopy and scanning electron microscopy characterization techniques. The elemental composition of the TiO2 deposited with different precursor concentrations was studied using X-ray photoelectron spectroscopy and electron dispersive X-ray spectroscopy. The amount of elemental carbon in the TiO2 matrix is found to be increased as the Ti precursor concentration is increased, which strengthens the proposed idea of carbon doping via a Ti precursor.Interstitial carbon doping is possible directly from a Ti precursor (titanium(iv) isopropoxide) without using any other carbon source. 相似文献