全文获取类型
收费全文 | 4507篇 |
免费 | 283篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 108篇 |
妇产科学 | 176篇 |
基础医学 | 493篇 |
口腔科学 | 50篇 |
临床医学 | 689篇 |
内科学 | 767篇 |
皮肤病学 | 71篇 |
神经病学 | 463篇 |
特种医学 | 98篇 |
外科学 | 485篇 |
综合类 | 46篇 |
一般理论 | 7篇 |
预防医学 | 629篇 |
眼科学 | 48篇 |
药学 | 285篇 |
中国医学 | 9篇 |
肿瘤学 | 350篇 |
出版年
2023年 | 36篇 |
2022年 | 93篇 |
2021年 | 133篇 |
2020年 | 76篇 |
2019年 | 115篇 |
2018年 | 107篇 |
2017年 | 102篇 |
2016年 | 68篇 |
2015年 | 112篇 |
2014年 | 152篇 |
2013年 | 209篇 |
2012年 | 319篇 |
2011年 | 290篇 |
2010年 | 201篇 |
2009年 | 163篇 |
2008年 | 286篇 |
2007年 | 259篇 |
2006年 | 273篇 |
2005年 | 273篇 |
2004年 | 244篇 |
2003年 | 244篇 |
2002年 | 206篇 |
2001年 | 50篇 |
2000年 | 48篇 |
1999年 | 38篇 |
1998年 | 37篇 |
1997年 | 41篇 |
1996年 | 30篇 |
1995年 | 20篇 |
1994年 | 24篇 |
1993年 | 29篇 |
1992年 | 49篇 |
1991年 | 42篇 |
1990年 | 32篇 |
1989年 | 45篇 |
1988年 | 25篇 |
1987年 | 39篇 |
1986年 | 29篇 |
1985年 | 36篇 |
1984年 | 24篇 |
1983年 | 24篇 |
1982年 | 14篇 |
1981年 | 16篇 |
1979年 | 17篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1976年 | 15篇 |
1974年 | 14篇 |
1973年 | 9篇 |
1971年 | 10篇 |
排序方式: 共有4799条查询结果,搜索用时 0 毫秒
1.
A convenience sample of hospital workers, those receiving influenza vaccine and those not receiving vaccine, were asked to complete questionnaires delineating the occurrence of symptoms (e.g., fever, headache, extreme tiredness, dry cough, sore throat, runny nose, stuffy nose, muscle aches) and absenteeism in the 7-day period post-vaccination if vaccinated. Those unvaccinated completed the questionnaire in a self-selected 7 consecutive day period during the study conducted from November 2004 to February 2005. Those receiving either Fluzone or FluMist reported significantly fewer symptoms and related absenteeism than the unvaccinated group (p < .05). Administration of influenza vaccine did not result in higher rates of post-vaccination symptoms as compared to an unvaccinated group. Further, vaccinated employees did not experience higher absenteeism rates as a result of receiving either influenza vaccine. However, for those reporting absenteeism as a result of symptoms, mean absenteeism days were highest in the FluMist group (4.5 days) compared to the unvaccinated group (2.1 days) and the Fluzone group (1.9 days). 相似文献
2.
Study DesignSystematic review.IntroductionContrast baths are used as an intervention in hand therapy, yet it is unclear which patients, if any, benefit from this intervention.Purpose of the StudyTo examine the nature and quality of the evidence regarding the use of contrast baths using a systematic review process.MethodsOf a total of 28 clinical research articles on contrast baths, from 1938 forward, ten met the inclusion criteria set by the authors.ResultsThese studies addressed the physiological changes of hot and cold on blood flow, intramuscular temperature, subcutaneous temperature, and the influence of room temperature and age. The subjects included normal/healthy volunteers and patients with a diagnosis of rheumatoid arthritis, diabetes, or foot/ankle injuries. The diversity of conditions, protocols, and outcomes limited the ability to make definitive conclusions on efficacy.ConclusionsThe contrast bath procedure may increase superficial blood flow and skin temperature, though the evidence on the impact on edema is conflicting. No relationship between physiologic effects and functional outcomes has been established.Level of Evidence: 2A 相似文献
3.
4.
P. H. B. Willemse J. G. Aalders J. Bouma N. H. Mulder R. C. J. Verschueren E. G. E. de Vries D. Th. Sleijfer 《Gynecologic oncology》1987,28(3):268-277
Thirteen patients with a malignant germ cell tumor of the ovary have been treated with a combination of vinblastine, bleomycin, and cisplatin (VBP). In 12 patients a complete remission was reached, which was maintained in 10 of these patients. One patient with large tumor residues and a partial remission became CR after surgery. The tumor recurred in 2 patients after 6 and 27 months. Overall, 11 of these patients are in long-term remission, from 14 to 84 months after the start of treatment. VBP is an effective treatment for malignant germ cell tumors of the ovary, even in patients with large tumor residuals. 相似文献
5.
VISUOMOTOR PERFORMANCE OF NORMAL AND CLUMSY CHILDREN. II: ARM-TRACKING WITH AND WITHOUT VISUAL FEEDBACK 总被引:2,自引:2,他引:0
J. H. P. van der Meulen J. J. Denier van der Gon C. C. A. M. Gielen R. H. J. M. Gooskens J. Willemse 《Developmental medicine and child neurology》1991,33(2):118-129
Tracking performance was investigated in normal and clumsy children in two age-groups, six to seven and 10 to 11 years. Target signals moving unpredictably along a straight line had to be tracked, both with and without visual feedback. Performance was described in three ways: (1) performance in the low-frequency range (LF); (2) the delay between target signal and tracking movement (DL); and (3) a measure of tracking quality or over-all similarity in the shape of target signal and tracking movement (Q). Clumsy children in both age-groups had a lower tracking quality (Q) and longer delay (DL) than the normal children. Disturbances in the regulation of attention seemed to affect tracking performance, particularly of the six- to seven-year-old clumsy children. There was no significant difference between normal and clumsy children in the effect of visual feedback on tracking performance. This suggests that clumsiness is not linked to disturbance of integration of visual feedback information and motor processes. 相似文献
6.
7.
Edward L. Morgan Brandon N. Morgan Elisabeth A. Stein Elizabeth L. Vitrs Marilyn L. Thoman Sam D. Sanderson Joy A. Phillips 《Vaccine》2009
A conformationally biased, agonist of human C5a65–74 (EP67) was assessed for its adjuvant activities in vitro and in vivo. EP67 induced the release of the inflammatory (Th1) type cytokines from C5a receptor (CD88)-bearing antigen presenting cells (APC). EP67 did not induce the release of these cytokines from splenic APCs obtained from C5a receptor knockouts (CD88−/−). Serum from mice immunized with EP67–ovalbumin (OVA) contained high OVA-specific antibody (Ab) titers [IgG1, IgG2a (IGg2c), IgG2b]. Mice receiving OVA alone produced only IgG1 Abs, indicating the ability of EP67 to induce a Th1-like Ab class switch. Spleen cell cultures from wild type mice but not CD88−/− mice showed an enhanced OVA-specific proliferative response in vitro. These results indicate the ability of EP67 to drive a Th1-mediated immune response and its potential use as a unique adjuvant. 相似文献
8.
Dorian Deshauer Anne Duffy Martin Alda Eva Grof Joy Albuquerque Paul Grof 《Revue canadienne de psychiatrie》2003,48(7):462-466
OBJECTIVE: A growing body of data suggests that a significantly enhanced salivary cortisol response to waking may indicate an enduring tendency to abnormal cortisol regulation. Our objective was to apply the response test to a population already known to have long-term hypothalamo-pituitary-adrenocortical (HPA) axis dysregulation. We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value. METHOD: Using the free cortisol response to waking and the short daytime profile, we tested 18 clinically stable, lithium-responsive subjects from our long-term naturalistic follow-up of monthly DSTs. These tests include salivary testing every 15 minutes during the first hour of waking, followed by samples taken at 3:00 PM and 8:00 PM. RESULTS: While clinically stable on lithium prophylaxis, patients with bipolar disorder (BD) showed a significantly enhanced salivary cortisol response to waking, compared with control subjects (P < 0.03). Cortisol levels 30 minutes after waking significantly exceeded those in the large normative data provided in the literature (P < 0.001). CONCLUSIONS: Our observations support the hypothesis that the free cortisol response to waking can reflect relatively enduring HPA dysregulation, even when lithium-responsive BD patients are clinically well and their DSTs are normal. Because the test is easy to administer, the free cortisol response to waking may hold promise as a marker in studies of high-risk families predisposed to, or at risk for, mood disorders. 相似文献
9.
10.
W Van der Meij A C Van Huffelen G H Wieneke J Willemse 《Electroencephalography and clinical neurophysiology》1992,82(6):408-414
Sequential topographic mapping was performed to differentiate "epileptic" from "non-epileptic" rolandic spikes. Twenty-four children without any indication of organic brain lesion were divided into a group with epilepsy and a group without epilepsy. The group with epilepsy was subdivided into "classical BECT" (benign focal epilepsy of childhood with centro-temporal spikes) and "non-classical BECT." Sequential mapping of the rolandic spikes revealed two different topographic patterns: a pattern of stationary potential fields and a pattern of non-stationary potential fields. The topographic pattern of stationary potential fields was morphologically represented by a single spike-and-wave complex whereas that of non-stationary potential fields was morphologically represented by a "double" spike-and-wave complex. Among the non-stationary topographic patterns represented by a "double" spike, one specific sequence of changes of potential fields was found. This sequence started with a dipolar field, with the negative pole in the frontal region and the positive pole in the centro-temporal region, morphologically represented by the small first spike of the "double" spike-and-wave complex. This dipolar field, changes to a unipolar or dipolar field, with a negative potential field in the centro-temporal region and, sometimes, a simultaneous positive potential field in the frontal region, morphologically represented by the prominent rolandic spike. This characteristic pattern was found to be significantly related to classical BECT. 相似文献