全文获取类型
收费全文 | 4773篇 |
免费 | 204篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 107篇 |
妇产科学 | 27篇 |
基础医学 | 546篇 |
口腔科学 | 104篇 |
临床医学 | 263篇 |
内科学 | 1363篇 |
皮肤病学 | 50篇 |
神经病学 | 401篇 |
特种医学 | 270篇 |
外科学 | 999篇 |
综合类 | 8篇 |
预防医学 | 134篇 |
眼科学 | 65篇 |
药学 | 257篇 |
中国医学 | 6篇 |
肿瘤学 | 363篇 |
出版年
2023年 | 20篇 |
2022年 | 53篇 |
2021年 | 86篇 |
2020年 | 51篇 |
2019年 | 74篇 |
2018年 | 105篇 |
2017年 | 71篇 |
2016年 | 112篇 |
2015年 | 98篇 |
2014年 | 116篇 |
2013年 | 161篇 |
2012年 | 253篇 |
2011年 | 278篇 |
2010年 | 144篇 |
2009年 | 136篇 |
2008年 | 238篇 |
2007年 | 267篇 |
2006年 | 254篇 |
2005年 | 270篇 |
2004年 | 226篇 |
2003年 | 266篇 |
2002年 | 251篇 |
2001年 | 112篇 |
2000年 | 135篇 |
1999年 | 124篇 |
1998年 | 100篇 |
1997年 | 62篇 |
1996年 | 56篇 |
1995年 | 46篇 |
1994年 | 48篇 |
1993年 | 32篇 |
1992年 | 77篇 |
1991年 | 67篇 |
1990年 | 48篇 |
1989年 | 61篇 |
1988年 | 40篇 |
1987年 | 47篇 |
1986年 | 46篇 |
1985年 | 40篇 |
1984年 | 37篇 |
1983年 | 41篇 |
1982年 | 37篇 |
1981年 | 17篇 |
1979年 | 17篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1974年 | 18篇 |
1973年 | 14篇 |
1972年 | 17篇 |
1966年 | 20篇 |
排序方式: 共有5002条查询结果,搜索用时 15 毫秒
1.
Mamoru Uemura MD Masahiko Higashiyama MD Jiro Okami MD Kazuyuki Oda MD Koji Takami MD Ken Kodama MD 《General thoracic and cardiovascular surgery》2006,54(2):289-292
We present a case of intrapulmonary metastasis developing 18 years after complete resection of thymoma. An 8 mm nodule in the lower lobe of the left lung was noted on chest X-ray in a 76-year-old woman who had undergone complete resection of Masaoka’s stage II thymoma 18 years earlier. Since the nodule grew to 17 mm during a 2-year follow-up, wedge resection was performed. The lesion was histologically diagnosed as an intrapulmonary metastasis from thymoma. Extremely late recurrence after complete resection of thymoma is discussed. 相似文献
2.
Antigen presentation by a B-cell line transfected with cloned immunoglobulin heavy- and light-chain genes specific for a defined hapten. 总被引:5,自引:1,他引:4 下载免费PDF全文
M Watanabe D R Wegmann A Ochi N Hozumi 《Proceedings of the National Academy of Sciences of the United States of America》1986,83(14):5247-5251
The rearranged genes encoding immunoglobulin heavy (mu) and light (kappa) chains specific for the hapten 2,4,6-trinitrophenyl (Tnp) were introduced into a B-lymphoma line that bears surface IgG with an unknown specificity and expresses surface Ia molecules. A transformant expressing surface IgM specific for Tnp was obtained. The transformant was found to present Tnp-proteins to antigen (protein)-specific T cells far more efficiently than the parenteral B-lymphoma line. This artificial system, utilizing recombinant DNA technology and gene transfer, provides several approaches for the study of T-cell-B-cell interactions. 相似文献
3.
4.
Yuji Maruyama Shigeo Yamauchi Hidetsugu Ogasawara Hajime Imura Masami Ochi Kazuo Shimizu 《Annals of thoracic and cardiovascular surgery》2006,12(1):60-62
Surgical treatment for subacute pulmonary arterial thromboembolism has previously been considered to be inappropriate. We undertook a pulmonary arterial thrombectomy and removal of a floating right heart thrombus in a patient who had been symptomatic for over a month. The pulmonary arterial pressure, which had been equal to the systemic pressure preoperatively, decreased gradually and almost normalized one month postoperatively. Pulmonary perfusion scintigraphy revealed a dramatic improvement and the patient returned to normal life activities. 相似文献
5.
Hirofumi Nakanishi Akira Myoui Takahiro Ochi Katsuyuki Aozasa 《Journal of cancer research and clinical oncology》1997,123(6):352-356
Multidrug resistance (MDR) is an important problem in chemotheraphy for neoplastic disease. In humans, MDR is mainly mediated by P-glycoprotein (P-gp), a product of theMDR1 gene, which acts as a transmembrane protein pump and eliminates chemotherapeutic agents from the cells. Expression of P-gp was immunohistochemically studied by using two monoclonal antibodies, JSB-1 and C-219, on paraffin-embedded sections from 55 patients with soft-tissue sarcoma. The histological diagnosis of tumors was malignant fibrous histiocytoma in 24 cases, liposarcoma in 9, synovial sarcoma in 7, malignant neurogenic tumors in 6, leiomyosarcoma in 5, others in 4. The histological grade was determined on the basis of criteria previously proposed by us. Out of 55 cases, 34 (62%) were positive for P-gp expression. There was a significant difference in P-gp expression between high-grade (90%) and intermediate and low-grade tumors (46%) (P<0.005). Tumors expressing P-gp had a less favorable prognosis than P-gp-negative tumors in the high- and intermediate-grade tumors. The current study demonstrated that the estimation of P-gp expression could be used to select appropriate therapeutic modalities.Abbreviations
MDR
multidrug resistance
-
P-gp
P-glyco-protein 相似文献
6.
S Shibata A Ochi H Yamashita A Yasunaga K Mori 《No shinkei geka. Neurological surgery》1990,18(6):527-531
The tumor vessels of a primary meningeal malignant melanoma were studied by electron microscopy. There were numerous endothelial fenestrae and basal lamina abnormalities in the intrinsic tumor capillaries. They resembled the tumor vessels found in nonglial tumors, but were distinctly different from those seen in glial tumors with nonfenestrated capillaries. These findings were anticipated because leptomeninges have fenestrated capillaries. 相似文献
7.
Yoshito Tomimaru Ken Kodama Jiro Okami Kazuyuki Oda Koji Takami Masahiko Higashiyama 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(5):193-198
Objective Postoperative pericardial effusion commonly occurs after open heart surgery. However, after general thoracotomy such as pulmonary
resection, there have been few reports of pericardial effusion. The purpose of this study is to investigate patients with
pericardial effusion following pulmonary resection.Methods: Among 2,385 patients with pulmonary resection for lung neoplasm in our institute, eight patients, whose pericardium had
never been opened during the operation, developed pericardial effusion. The clinical characteristics of the eight patients
were analyzed.Results: Pericardial effusion after pulmonary resection was divided into two subtypes: pericardial effusion in three patients with
left thoracotomy occurring within 30 days postoperatively, and pericardial effusion in the remaining five patients with right
thoracotomy occurring more than 30 days postoperatively. Pericardiotomy or pericardiocentesis was performed in three symptomatic
patients, and the remaining five asymptomatic patients were treated with diuretics. Pericardial effusion disappeared in three
of the five patients about 1–3 months after the conservative treatment, while, in the remaining patients, because pericardial
effusion had increased gradually, pericardiocentesis was performed.Conclusion: From our experience, the treatment strategy of drainage for early pericardial effusion and diuretics for late pericardial
effusion seems to be appropriate. (Jpn J Thorac Cardiovasc Surg 2006; 54:193-198) 相似文献
8.
The effects of prior 24-hour ureteral obstruction on ischemic renal damage were studied in rats. Rats were divided into 6 groups with different times of ischemia (0, 60 and 90 min) and with or without 24-hour ureteral obstruction. Following a 4-week recovery period, contralateral nephrectomy was performed and the rat was sacrificed 24 h later for the determination of serum creatinine and for histologic examination of the affected kidney. A preceding ureteral obstruction for 24 h made no difference to the renal damage with 60 min of ischemia or without ischemia. However, kidneys with 90 min of ischemia and 24 h of ureteral obstruction were more damaged than those with 90 min of ischemia only. These results suggested that the hydronephrotic kidney was more susceptible to long periods of ischemia than the normal kidney. 相似文献
9.
10.