全文获取类型
收费全文 | 196篇 |
免费 | 7篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 16篇 |
口腔科学 | 18篇 |
临床医学 | 32篇 |
内科学 | 82篇 |
皮肤病学 | 17篇 |
神经病学 | 2篇 |
外科学 | 13篇 |
一般理论 | 1篇 |
预防医学 | 7篇 |
眼科学 | 2篇 |
药学 | 8篇 |
出版年
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 15篇 |
2012年 | 4篇 |
2011年 | 4篇 |
2010年 | 8篇 |
2009年 | 4篇 |
2007年 | 1篇 |
2006年 | 1篇 |
2005年 | 1篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 9篇 |
1998年 | 14篇 |
1997年 | 7篇 |
1996年 | 16篇 |
1995年 | 8篇 |
1994年 | 9篇 |
1993年 | 9篇 |
1992年 | 12篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1974年 | 1篇 |
1969年 | 1篇 |
1965年 | 1篇 |
1964年 | 2篇 |
1963年 | 2篇 |
1961年 | 1篇 |
1959年 | 1篇 |
1958年 | 2篇 |
1957年 | 1篇 |
1956年 | 2篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有203条查询结果,搜索用时 15 毫秒
1.
TAMPIER LUTSKE; QUINTANILLA MARIA ELENA; MARDONES JORGE 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):751-755
In order to explore the influence of acetaldehyde (AcH) metabolismon the voluntary ethanol intake of genetically low (UChA) andhigh (UChB) ethanol consumer rats, the AcH disappearance rate(ADR) after incubation with homogenates and subcellular fractionsfrom liver and brain was determined. In addition, the effectof disulfiram pretreatment on AcH metabolism was studied. Maleadult rats of both strains were used. ADR was assayed in totalhomogenates, and in mitochondrial as well as 9000 g supernatantfractions of liver and brain. AcH was measured by gas chromatography.In some experiments, rats were pretreated with disulfiram (300mg/kg po) 24 hr before the studies. The result showed no straindifference in ADR in homogenates or subcellular fractions ofliver from untreated rats, but for disulfiram pretreated ratsa significantly lower decrease of ADR in samples from UChB comparedto UChA rats was observed. This result is consistent with alower peak AcH level in UChB compared to UChA rats after a loadof ethanol (60 mmole/kg ip). Concerning brain homogenates, ahigher ADR was observed in homogenates and crude mitochondrialfractions of UChB than of UChA rats. This difference was notobserved when the incubation was performed without adding NADor in the absence of oxygen. These results provide evidenceof strain differences in mitochondrial AcH metabolism, the natureand origin of which deserve further study. 相似文献
2.
HIROSHI KATAOKA JORGE P. LI ALFRED S.T. LUI STEVEN J. KRAMER DAVID A. SCHOOLEYS 《Chemical biology & drug design》1992,39(1):29-35
The locations of the three disulfide bonds of eclosion hormone (EH) isolated from Manduca sexta were assigned by sequence analysis of thermolysin fragments and by comparison of a key heterodimeric fragment to regiospecifically synthesized parallel and antiparallel isomers. We elucidated the complete structure of Manduca EH as a 62-residue peptide which has three disulfide bonds between Cys14-Cys38, Cys18-Cys34, and Cys21-Cys49. 相似文献
3.
PINTO A.; SCAGLIONE R.; GALATI D.; PATERNA S.; PARRINELLO G.; ARNONE S.; LICATA G. 《European heart journal》1995,16(11):1692-1697
This study was designed to analyse the relationship betweenarterial hypertension and changes in arterial blood flow andvascular wall damage of the lower limbs in hypertensive patientswith various degrees of hypertension. Six hundred and fifty-four hypertensive patients (421 malesand 233 females) aged 35 to 70 years and 88 healthy subjects(63 males and 25 females) aged 39 to 60 years were studied.Strain-gauge plethysmography of the lower limbs was used tocalculate arterial calf blood flow (RF), arterial calf bloodflow after post-ischaemic hyperaemia (PF), basal and minimalvascular resistances (BVR and MVR), time to reach peak flow(tPF), time until 50% reduction of peak flow (tT) and totalrecovery time (tT). In 108 (67 males and 41 females) of the hypertensive patients,a morphological study by echo-Doppler duplex scanning of thepopliteal artery was performed to measure medial-intimal thickeningand popliteal lumen diameter. Our results indicate that regional haemodynamics of the lowerlimbs worsened in hypertensives in comparison with control subjects.In addition, the change in peripheral haemodynamics was relatedto the degree of hypertension. Moreover, medial-intimal thickeningwas significantly (P<0.05) higher in severe hypertensivesthan mild hypertensives. Popliteal lumen diameter was significantly(P<0.05) lower in severe hypertensives than moderate andmild hypertensives. In all these subjects mean blood pressurewas correlated directly (r=0.31; P<0.001) with medial-intimalthickening and inversely (r= 0.37; P<0.001) withpopliteal lumen diameter. Multiple regression analysis indicatedthat mean blood pressure, age and serum cholesterol were independentlycorrelated to medial-intimal thickening. This relationship wasnot influenced by the diabetic patients and smokers among thegroups. Our results indicate that hypertension impairs peripheral flowand encourages the development of medial-intimal thickening. 相似文献
4.
MARCO SCAGLIONE M.D. DOMENICO CAPONI M.D. MATTEO ANSELMINO M.D. Ph.D. FRANCESCA DI CLEMENTE M.D. ALESSANDRO BLANDINO M.D. FEDERICO FERRARIS M.D. PAOLO DI DONNA M.D. ELISA EBRILLE M.D. FRANCK HALIMI M.D. JEAN F. LECLERCQ M.D. COSTANZA IUNCO M.D. CARLOEUGENIO VAUDAGNA M.D. FEDERICO CESARANI M.D. FIORENZO GAITA M.D. 《Journal of cardiovascular electrophysiology》2014,25(12):1299-1305
5.
Cristiane S. ALC?NTARA Allana F.C. de MACêDO Bruno C.V. GURGEL Janaina H. JORGE Karin H. NEPPELENBROEK Vanessa M. URBAN 《Journal of applied oral science : revista FOB》2012,20(6):607-612
In order to prolong the clinical longevity of resilient denture relining materials
and reduce plaque accumulation, incorporation of antimicrobial agents into these
materials has been proposed. However, this addition may affect their properties.
Objective
This study evaluated the effect of the addition of antimicrobial agents into one soft liner (Soft Confort, Dencril) on its peel bond strength to one denture base (QC 20, Dentsply).Material and Methods
Acrylic specimens (n=9) were made (75x10x3 mm) and stored in distilled water at 37ºC for 48 h. The drug powder concentrations (nystatin 500,000U - G2; nystatin 1,000,000U - G3; miconazole 125 mg - G4; miconazole 250 mg - G5; ketoconazole 100 mg - G6; ketoconazole 200 mg - G7; chlorhexidine diacetate 5% - G8; and 10% chlorhexidine diacetate - G9) were blended with the soft liner powder before the addition of the soft liner liquid. A group (G1) without any drug incorporation was used as control. Specimens (n=9) (75x10x6 mm) were plasticized according to the manufacturers'' instructions and stored in distilled water at 37ºC for 24 h. Relined specimens were then submitted to a 180-degree peel test at a crosshead speed of 10 mm/min. Data (MPa) were analyzed by analysis of variance (α=0.05) and the failure modes were visually classified.Results
No significant difference was found among experimental groups (p=0.148). Cohesive failure located within the resilient material was predominantly observed in all tested groups.Conclusions
Peel bond strength between the denture base and the modified soft liner was not affected by the addition of antimicrobial agents. 相似文献6.
Marcia Carneiro VALERA Lilian Eiko MAEKAWA Luciane Dias de OLIVEIRA Antonio Olavo Cardoso JORGE érika SHYGEI Cláudio Antonio Talge CARVALHO 《Journal of applied oral science : revista FOB》2013,21(2):118-123
Objective:
The aim of this study was to evaluate the antimicrobial activity of auxiliary chemical substances and natural extracts on Candida albicans and Enterococcus faecalis inoculated in root canals.Material and Methods:
Seventy-two human tooth roots were contaminated with C. albicans and E. faecalis for 21 days. The groups were divided according to the auxiliary chemical substance into: G1) 2.5% sodium hypochlorite (NaOCl), G2) 2% chlorhexidine gel (CHX), G3) castor oil, G4) glycolic Aloe vera extract, G5) glycolic ginger extract, and G6) sterile saline (control). The samples of the root canal were collected at different intervals: confirmation collection, at 21 days after contamination; 1st collection, after instrumentation; and 2nd collection, seven days after instrumentation. Microbiological samples were grown in culture medium and incubated at 37º C for 48 hours.Results:
The results were submitted to the Kruskal-Wallis and Dunn (5%) statistical tests. NaOCl and CHX completely eliminated the microorganisms of the root canals. Castor oil and ginger significantly reduced the number of CFU of the tested bacteria. Reduction of CFU/mL at the 1st and 2nd collections for groups G1, G2, G3 and G4 was greater in comparison to groups G5 and G6.Conclusion:
It was concluded that 2.5% sodium hypochlorite and 2% chlorhexidine gel were more effective in eliminating C. albicans and E. faecalis, followed by the castor oil and glycolic ginger extract. The Aloe vera extract showed no antimicrobial activity. 相似文献7.
KARIN S WALSH JORGE I VÉLEZ PETER G KARDEL DANIEL M IMAS MAXIMILIAN MUENKE ROGER J PACKER FRANCISCO X CASTELLANOS MARIA T ACOSTA 《Developmental medicine and child neurology》2013,55(2):131-138
Aim Difficulties in neurocognition and social interaction are the most prominent causes of morbidity and long‐term disability in children with neurofibromatosis type 1 (NF1). Symptoms of attention‐deficit–hyperactivity disorder (ADHD) have also been extensively recognized in NF1. However, systematic evaluation of symptoms of autism spectrum disorder (ASD) in children with NF1 has been limited. Method We present a retrospective, cross‐sectional study of the prevalence of symptoms of ASD and ADHD and their relationship in a consecutive series of 66 patients from our NF1 clinic. The Social Responsiveness Scale and the Vanderbilt ADHD Diagnostic Parent Rating Scale were used to assess symptoms of ASD and ADHD. Results Sixty‐six participants (42 males, 24 females) were included in this study. Mean age at assessment was 10 years 11 months (SD 5y 4mo). Forty percent of our NF1 sample had raised symptom levels reaching clinical significance on the Social Responsiveness Scale (T ≥ 60), and 14% reached levels consistent with those seen in children with ASDs (T ≥ 75). These raised levels were not explained by NF1 disease severity or externalizing/internalizing behavioral disorders. There was a statistically significant relationship between symptoms of ADHD and ASD (χ2=9.11, df=1, p=0.003, φ=0.56). Particularly salient were the relationships between attention and hyperactivity deficits, with impairments in social awareness and social motivation. Interpretation We found that symptoms of ASD in our NF1 population were raised, consistent with previous reports. Further characterization of the specific ASD symptoms and their impact on daily function is fundamental to the development and implementation of effective interventions in this population, which will probably include a combination of medical and behavioral approaches. 相似文献
8.
CARDOSO J. L. C.; FAN H. W.; FRANCA F. O. S.; JORGE M. T.; LEITE R. P.; NISHIOKA S. A.; AVILA A.; SANO-MARTINS I. S.; TOMY S. C.; SANTORO M. L.; CHUDZINSKI A. M.; CASTRO S. C. B.; KAMIGUTI A. S.; KELEN E. M. A.; HIRATA M. H.; MIRANDOLA R. M. S.; THEAKSTON R. D. G.; WARRELL D. A. 《QJM : monthly journal of the Association of Physicians》1993,86(5):315-325
In São Paulo City, Brazil, 121 patients with moderatelysevere envenoming by Bothrops snakes (principally B. jararaca)were randomized for treatment with Brazilian polyspecific Bothropsantivenoms: Instituto Butantan (39 patients), Instituto VitalBrazil (41), Fundação Ezequiel Dias (FUNED) (41).The initial dose was four ampoules (40 ml) in 89 patients withless severe envenoming and eight ampoules (80 ml) in 32 patientswith more severe envenoming. A second dose of four ampouleswas required in 20 patients. Patients receiving the three antivenoms were comparable in allrespects before treatment There were no deaths. The majorityshowed rapid clinical improvement, resolution of local envenoming,cessation of bleeding and restoration of blood coagulability.No differences in the efficacy of the three antivenoms wererevealed by clinical or laboratory observations, including measuresof haematological, haemostatic and biochemical ab normalities.Twelve patients developed abscesses (Butantan 1, Vital Brazil6, FUNED 5) and seven developed local necrosis (3,1,3). Of 88patients followed up 2030 days after the bite 33 (37.5%)still had symptoms or signs of local envenoming, especiallyswelling. Early (anaphylactic) reactions were unexpectedly frequent afterall three antivenoms but were significantly more frequent withButantan (87%) than with Vital Brazil (37%) or FUNED (56%) antivenoms(p < 0.001). A possible explanation was the higher totalprotein content and percentage immunoglobulin of Butantan antivenom. The doses of antivenom recommended in Brazil and used in thisstudy may be unnecessarily high, resulting in an unacceptablyhigh incidence of reactions. Results of the study should prompta critical re-evaluation of antivenom production techniquesand dosage recommendations in Brazil. 相似文献
9.
BRUNO T. ROSA DDS MS HARALD O. HEYMANN DDS MED EDWARD J. SWIFT JR. DMD MS JORGE PERDIGAO DMD MS PHD ANDRE V. RITTER DDS 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》2000,12(3):139-145
Purpose: To evaluate resin bond strength to enamel contaminated with handpiece oil. Materials and Methods: Bovine teeth were randomly assigned to six groups of 20 teeth each for treatment with one of six different bonding systems (five one‐bottle and one multibottle). For each system, 10 enamel specimens were contaminated with handpiece oil before acid‐etching and 10 were contaminated after acid‐etching. The enamel was etched for 15 seconds using 35% phosphoric acid. Following adhesive application, composite resin was bonded using a gelatin capsule technique. Shear bond strengths from the two contaminated groups were compared to bond strengths to uncontaminated enamel obtained from a previous study that was performed by the same group of investigators, using the same facility, materials, and methods. Results: Two‐way analysis of variance (ANOVA) showed that the factor “surface contamination” did not have a significant effect on bond strength (p > .542). The type of adhesive and the interaction of adhesive and surface contamination were significant (p <.0001 and p <.003, respectively). When oil was applied before etching, mean bond strengths ranged from 18.0 ± 4.8 MPa for OptiBond SOLO (Kerr Corp., Orange, California) to 25.3 ± 5.6 MPa for Tenure Quik with Fluoride (Den‐Mat Corp., Santa Maria, California). With oil applied after etching, bond strengths ranged from 18.4 ± 8.0 MPa for Tenure Quik with Fluoride to 27.4 ± 5.4 MPa for Single Bond (3M Dental Products, St. Paul, Minnesota). For the same adhesive, comparing uncontaminated and “oil‐before‐etch” contaminated groups, the only statistically significant difference in bond strengths was for OptiBond SOLO: 21.8 ± 4.0 MPa (uncontaminated) versus 18.0 ± 4.8 MPa (oil before etch). Comparing uncontaminated and “oil‐after‐etch” groups, the only statistically significant difference was for Tenure: 24.5 ± 5.7 MPa (uncontaminated) and 18.4 ± 8.0 MPa (oil after etch). CLINICAL SIGNIFICANCE Surface contamination with handpiece lubricant oil does not impair appreciably the efficacy of the adhesives used in this study when bonding composite resin to enamel. 相似文献
10.
JUAN LEAL DEL OJO M.D. RICARDO PAVÓN M.D. DOLORES GARCÍA M.D. JAVIER QUINTANA M.D. JORGE CAPARRÓS M.D. DAVID VILLAGOMEZ M.D. MARIA VAZQUEZ M.D. JOSÉ MIGUEL BARQUERO M.D. LUIS PASTOR M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(2):e38-e40
We describe a 72‐year‐old man referred for implantation of a cardiac resynchronization therapy device who had previously undergone repeated operations to replace the mitral valve. Retrograde venography of the coronary sinus (CS) to implant the left ventricular (LV) pacing lead revealed aneurysmal dilatation of the CS with LV‐CS fistula that hindered—but did not prevent—complete implantation of the system. (PACE 2013; 36:e38–e40) 相似文献