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1.
Gimaev RKh Rukhov VI Drapova DP Razin VA Iudina EE Auadi KhB Sharangin SA 《Klinicheskaia meditsina》2007,85(8):37-40
The aim of the work was to evaluate the effects of drug and non-drug methods of treatment of patients with essential hypertension (EH) on ventricular late potentials (VLP). One hundred and thirteen patients with I to II stage EH aged 30 to 73 (mean age 53 +/- 9.7 years) were included in the study. VLP were registered by recording signal-averaged ECG (SA-ECG) before and after treatment with antihypertensive preparations (lisinopril, nifedipine) and intravenous ozone therapy. VLP were detected in 34 (30%) of the EH patients. The study found a decrease in the frequency of VLP detection from 40% (8 patients) to 10% (2 patients) after therapy with the ACE inhibitor lisinopril. In the group of patients who received monotherapy with the calcium antagonist nifedipine the number of subjects with VLP before and after the treatment was the same, 3 patients or 20%. In the group receiving bi-component therapy with lisinopril, an ACE inhibitor, and nifedipine, a calcium antagonist, the number of patients with VLP fell from 4 subjects (28.6%) to 1 subject. These data were confirmed with significant SA-ECG parameters. The study also revealed that ozone therapy as a part of complex treatment of EH improved SA-ECG parameters, which manifested by a decrease in VLP from 29.7% to 14.1%. 相似文献
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Boĭtsov SA Kuchmin AN Beozertseva IV Karetkina EI Iudina OV Medvedeva EV 《Terapevticheski? arkhiv》2003,75(3):15-18
AIM: To evaluate sympathetic nervous system activity of the heart in patients with bronchial asthma (BA) given beta-adrenomimetics (BAM). MATERIAL AND METHODS: 27 patients with moderate BA (13 patients in an acute phase and 14 patients in remission) treated with BAM and 13 healthy people were examined by using 123I-metaiodobenzylguanidine (MIBG) myocardial planar scintigraphy and estimating the washout rate, early (15-min) and late (240-min) uptake; single-photon emission computed tomography; assessment of MIBG distribution in the left ventricular myocardium, catecholamine excretion with urine. RESULTS: It was found that the MIBG washout rate was significantly higher in asthmatic patients especially in the acute period. The cardiac MIBG uptake was significantly lower in the group of patients with impaired cardiac sympathetic activity. More inhomogeneous myocardial MIBG uptake also occurred in the asthmatic group. Norepinephrine and epinephrine excretion was significantly higher in patients with bronchial asthma and cathecholamine and MIBG excretions correlated. CONCLUSION: Cardiac functional sympathetic activity impairment in asthmatic patients was shown by increased MIBG washout rate and reduced myocardial MIBG uptake, more inhomogeneous substance distribution in the left ventricular myocardium and higher catecholamine excretion levels reflecting sympathetic nervous activity intensification. 相似文献
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On the basis of a significant amount of experimental studies of toxic effect of pesticides attributed to different groups of chemical substances a rapid calculating and experimental technique for hygienic standardization of pesticide content in foodstuffs has been set forth. The proposed technique enables one to define quickly and safely the threshold and inert pesticide doses and to reduce general duration of toxicologic experiments by 35%. 相似文献
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