排序方式: 共有45条查询结果,搜索用时 15 毫秒
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Serdar Coskun Samira Madan Ibtihal Bukhari Saad Al-Hassan Rafat Al-Rejjal Khalid Awartani 《European journal of obstetrics, gynecology, and reproductive biology》2010
Objectives
The aim of this study was to investigate the prognosis in future IVF cycles of patients with empty follicle syndrome (EFS).Study design
EFS cases and their future cycles were reviewed. Clinical pregnancy rate per started cycle was taken as the primary outcome in assessing the future outcome in IVF treatment cycles.Results
A total of 3023 patients underwent 5238 IVF treatment cycles. Twenty-six patients (1%) had a total of 58 (1%) cycles of EFS. Thirteen women went through 32 further IVF treatment cycles following the diagnosis of EFS, yielding only two clinical pregnancies, giving a clinical pregnancy rate of 6.25% per started cycle. In addition, four patients had recurrence in a total of 15 cycles.Conclusions
The occurrence of EFS will indicate poor IVF success in subsequent IVF cycles. Patients with “genuine EFS” should be counselled about the outcome of their future IVF cycles. 相似文献5.
Rui Yang Marc Weisshaar Federico Mele Ibtihal Benhsaien Karim Dorgham Jing Han Carys A. Croft Samuele Notarbartolo Jrmie Rosain Paul Bastard Anne Puel Bernhard Fleckenstein Laurie H. Glimcher James P. Di Santo Cindy S. Ma Guy Gorochov Aziz Bousfiha Laurent Abel Stuart G. Tangye Jean-Laurent Casanova Jacinta Bustamante Federica Sallusto 《The Journal of experimental medicine》2021,218(8)
We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacterial-reactive purely adaptive, lymphocytes. Here, we explore the persistent upper airway inflammation (UAI) and blood eosinophilia of this patient. Unlike wild-type (WT) T-bet, the mutant form of T-bet from this patient did not inhibit the production of Th2 cytokines, including IL-4, IL-5, IL-9, and IL-13, when overexpressed in T helper 2 (Th2) cells. Moreover, Herpesvirus saimiri–immortalized T cells from the patient produced abnormally large amounts of Th2 cytokines, and the patient had markedly high plasma IL-5 and IL-13 concentrations. Finally, the patient’s CD4+ αβ T cells produced most of the Th2 cytokines in response to chronic stimulation, regardless of their antigen specificities, a phenotype reversed by the expression of WT T-bet. T-bet deficiency thus underlies the excessive production of Th2 cytokines, particularly IL-5 and IL-13, by CD4+ αβ T cells, causing blood eosinophilia and UAI. The MSMD of this patient results from defective IFN-γ production by innate and innate-like adaptive lymphocytes, whereas the UAI and eosinophilia result from excessive Th2 cytokine production by adaptive CD4+ αβ T lymphocytes. 相似文献
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Mohamed SY Fadhil I Hamladji RM Hamidieh AA Fahmy O Ladeb S Alimoghaddam K Elhaddad A Nacer RA Alsharif F Rasheed W Jahani M Mousavi SA Alseraihy A Abdel-Rahman F Al Jefri A Hussein AA Alabdulaaly A Ibrahim A Bekadja MA Abboud M Ahmed P Dennison D Bakr M Benchekroun S Hussain F Othman TB Aljurf M Ghavamzadeh A 《Hematology/oncology and stem cell therapy》2011,4(2):81-93
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Ibtihal Ibrahim Hala Salah Hanan El Sayed Hader Mansour Ahmed Eissa Joel Wood 《Journal of clinical and experimental neuropsychology》2016,38(8):861-868
Background: Hepatitis C virus (HCV) infection is associated with cognitive dysfunction in clinic-based studies. The risk could be attributed to factors such as antiviral medications, substance abuse, or coincidental infection. Aim: The aim was to evaluate cognitive function in relation to HCV antibody titers in a community-based sample of asymptomatic individuals at low risk for substance abuse. Method: Adults were ascertained from a community in Mansoura, Egypt, where HCV is endemic (n = 258). Cognitive performance was evaluated using the Arabic version of the Penn Computerized Neurocognitive Battery. Substance abuse and psychopathology were also assessed. Antibodies to HCV and Toxoplasma gondii (TOX), a common protozoan that can affect cognition, were estimated using serological IgG assays. Results: The prevalence of HCV and TOX infection was 17.6% and 52.9%, respectively. HCV antibody titers were significantly associated with worse function in four cognitive tests for accuracy and three tests for speed, after adjusting for covariates (p < .05, beta coefficients, 2.1–3.2). TOX antibody titers were associated with impaired accuracy in one test. Conclusions: The association between HCV antibody titers and cognitive impairment is not mediated by antiviral treatment or substance abuse in this sample. Whether HCV has a causal role in the cognitive dysfunction should be investigated. 相似文献