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Altogether 16 persons with STH-producing hypophyseal adenoma were investigated by tacho-oscillography, total rheography, blood taken from the ulnar vein, a radioimmunoassay to determine the levels of STH, ACTH, cortisol, deoxycorticosterone, aldosterone, T3, T4, vasopressin, prostaglandin E2, 6-keto-prostaglandin F1 alpha, and plasma renin activity. Acromegalic patients demonstrated an elevated level of STH, and prostaglandin E2 secretion was inhibited. Two groups of patients were singled out according to the hemodynamic state: the 1st group was characterized by a hyperkinetic type of circulation and normotension of borderline hypertension; the 2nd group was characterized by hypokinetic circulation, increased vascular resistance, labile or stable arterial hypertension. The interrelationship of hemodynamic and hormonal indices was unnoticed. It has been assumed that of pathogenetic importance in the development of arterial hypertension is depletion of E2 production, and at early stages--body liquid retention resulting from hypersomatotropinemia. 相似文献
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V M Kliuzhev A K Ognev V N Iakovlev Iu U Man'kov I B Sliusar D F Nechaev 《Voenno-medit?sinski? zhurnal》1992,(11):36-7, 80
The article analyses the results of the complex examination of 52 patients with large-focal and through-and-through myocardial infarction using veloergometry, echocardiography, tetrapolar rheography, diurnal ECG monitoring at cardioanalyzer. It was found out that veloergometry was more preferable in the late hospital period. Echocardiography was more preferable in the sanitary-polyclinic period for the young and middle-aged patients with through-and-through myocardial infarction, and at the late hospital period for elderly patients with large-focal and through-and-through myocardial infarction. In both periods described above echocardiography was effective in young and middle-aged patients with large-focal myocardial infarction. As for the volume of information obtained with the help of tetrapolar rheography and diurnal ECG monitoring it was equal in both periods. 相似文献
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V N Slavnov V V Markov E V Luchitski? A A Iakovlev I V Komissarenko 《Problemy e?ndokrinologii》1988,34(5):19-23
The results of investigation of the secretion of hypophyseal, adrenal and renal hormones resulting from parlodel administration in 44 patients with Itsenko-Cushing disease were discussed. Concentrations of corticotropin (ACTH), prolactin, somatotropin (STH), thyrotropin (TSH), cortisol, aldosterone, adrenalin, noradrenaline, dopamine and blood renin activity were determined by radioimmunoassays and radioenzymatic methods on an empty stomach and 30, 60 min., 2, 4 and 24 h after parlodel administration (2.5 mg) per os. Parlodel administration in Itsenko-Cushing disease was shown to cause a decrease in the secretion of hypophyseal hormones (ACTH, prolactin and STH). The level of cortisol raised before the start of the investigation was gradually decreased after the drug administration and reached its minimum in 2-4 h. Correlation of the basal level of aldosterone and blood renin activity, and a response of the renin-angiotensin-aldosterone system to parlodel administration was revealed. Changes in the secretion of catecholamines were of diverse nature: a decrease in the blood concentration of noradrenaline in the absence of adrenalin and dopamine shifts. 相似文献
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Altogether 103 patients with acute pneumonia and 50 healthy controls were examined. A wide range of clinical and immunological methods was applied. The data obtained were processed using statistical multivariate analyses. Differences of a clinical picture and the immune status were shown in primary patients and in patients with repeated pneumonia. An attempt was made to explain the pathogenesis of repeated pneumonia. The use of immunomodulating agents for therapy and prevention of acute pneumonia was substantiated. 相似文献
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Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development
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S Sampath BL Somani YV Sharma MM Arora VN Arabade 《Medical Journal Armed Forces India》2002,58(4):315-318
Ornithine carbamoyl transferase (OCT) activity and other liver function tests were studied in a total of 50 patients of clinical malaria and 15 controls. They were grouped as group I (positive for malarial parasite on peripheral blood smear, n=18), group II (negative for malarial parasite on peripheral blood smear (PBS) but responded to antimalarials, n=17) and group III (peripheral blood smear negative and did not respond to antimalarial therapy, n=15). The mean OCT levels were significantly raised in group I (6.79 ± 1.84 IU/L, p value = 0.006) and group II (5.0 ± 1.15 IU/L, p value = 0.014) as compared to controls (2.5 ± 1.13 IU/L) and returned to normal after treatment In contrast, group III had normal levels except in a case of kala azar and septicemia where OCT levels were high and increased further on treatment. Taking PBS positivity as a gold standard of diagnostic criteria, OCT had a sensitivity of 83% and specificity of 86% with a high positive predictive value of 88% as compared to ALT which had a lower sensitivity of 55% and specificity of 80%. The clinical response rate in PBS negative cases of fever having high OCT level was 83% as compared to 35% in cases with normal OCT level, making OCT a good surrogate marker of malaria. OCT levels could also be of prognostic significance as 2 cases of cerebral malaria had high OCT levels of 11.1 UAL and 10.7 IU/L, respectively.Key Words: Malaria, Ornithine carbamoyl transferase 相似文献