全文获取类型
收费全文 | 309055篇 |
免费 | 18363篇 |
国内免费 | 537篇 |
专业分类
耳鼻咽喉 | 4488篇 |
儿科学 | 10517篇 |
妇产科学 | 10579篇 |
基础医学 | 46923篇 |
口腔科学 | 7875篇 |
临床医学 | 25251篇 |
内科学 | 58408篇 |
皮肤病学 | 6556篇 |
神经病学 | 22028篇 |
特种医学 | 12237篇 |
外国民族医学 | 43篇 |
外科学 | 48479篇 |
综合类 | 7915篇 |
现状与发展 | 1篇 |
一般理论 | 161篇 |
预防医学 | 20628篇 |
眼科学 | 7369篇 |
药学 | 22019篇 |
中国医学 | 953篇 |
肿瘤学 | 15525篇 |
出版年
2021年 | 2672篇 |
2019年 | 2568篇 |
2018年 | 4037篇 |
2017年 | 2950篇 |
2016年 | 3458篇 |
2015年 | 4053篇 |
2014年 | 5204篇 |
2013年 | 8038篇 |
2012年 | 10309篇 |
2011年 | 10622篇 |
2010年 | 6784篇 |
2009年 | 6094篇 |
2008年 | 9448篇 |
2007年 | 10224篇 |
2006年 | 10053篇 |
2005年 | 9556篇 |
2004年 | 9202篇 |
2003年 | 8609篇 |
2002年 | 8158篇 |
2001年 | 13668篇 |
2000年 | 13949篇 |
1999年 | 11641篇 |
1998年 | 3106篇 |
1997年 | 2834篇 |
1996年 | 2668篇 |
1995年 | 2588篇 |
1994年 | 2383篇 |
1992年 | 8423篇 |
1991年 | 8536篇 |
1990年 | 8343篇 |
1989年 | 8158篇 |
1988年 | 7383篇 |
1987年 | 7130篇 |
1986年 | 6768篇 |
1985年 | 6559篇 |
1984年 | 4788篇 |
1983年 | 4144篇 |
1982年 | 2486篇 |
1979年 | 4440篇 |
1978年 | 3244篇 |
1977年 | 2744篇 |
1976年 | 2514篇 |
1975年 | 2846篇 |
1974年 | 3369篇 |
1973年 | 3372篇 |
1972年 | 3127篇 |
1971年 | 2956篇 |
1970年 | 2843篇 |
1969年 | 2586篇 |
1968年 | 2543篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Michels Guido Horn Rudolf Helfen Andreas Hagendorff Andreas Jung Christian Hoffmann Beatrice Jaspers Natalie Kinkel Horst Greim Clemens-Alexander Knebel Fabian Bauersachs Johann Busch Hans-Jörg Kiefl Daniel Spiel Alexander O. Marx Gernot Dietrich Christoph F. 《Der Anaesthesist》2022,71(4):307-310
Die Anaesthesiologie - 相似文献
2.
Two Janus-associated kinase inhibitors (JAKi) (initially ruxolitinib and, more recently, fedratinib) have been approved as treatment options for patients who have intermediate-risk and high-risk myelofibrosis (MF), with pivotal trials demonstrating improvements in spleen volume, disease symptoms, and quality of life. At the same time, however, clinical trial experiences with JAKi agents in MF have demonstrated a high frequency of discontinuations because of adverse events or progressive disease. In addition, overall survival benefits and clinical and molecular predictors of response have not been established in this population, for which the disease burden is high and treatment options are limited. Consistently poor outcomes have been documented after JAKi discontinuation, with survival durations after ruxolitinib ranging from 11 to 16 months across several studies. To address such a high unmet therapeutic need, various non-JAKi agents are being actively explored (in combination with ruxolitinib in first-line or salvage settings and/or as monotherapy in JAKi-pretreated patients) in phase 3 clinical trials, including pelabresib (a bromodomain and extraterminal domain inhibitor), navitoclax (a B-cell lymphoma 2/B-cell lymphoma 2-xL inhibitor), parsaclisib (a phosphoinositide 3-kinase inhibitor), navtemadlin (formerly KRT-232; a murine double-minute chromosome 2 inhibitor), and imetelstat (a telomerase inhibitor). The breadth of data expected from these trials will provide insight into the ability of non-JAKi treatments to modify the natural history of MF. 相似文献
3.
Sung‐Hyun Hwang Myung‐Chul Kim Sumin Ji Yeseul Yang Yeji Jeong Yongbaek Kim 《Cancer science》2019,110(4):1256-1267
Metformin, a drug for type 2 diabetes mellitus, has shown therapeutic effects for various cancers. However, it had no beneficial effects on the survival rate of human malignant mesothelioma (HMM) patients. The present study was performed to elucidate the underlying mechanism of metformin resistance in HMM cells. Glucose‐starved HMM cells had enhanced resistance to metformin, demonstrated by decreased apoptosis and autophagy and increased cell survival. These cells showed abnormalities in mitochondria, such as decreased ATP synthesis, morphological elongation, altered mitochondrial permeability transition pore and hyperpolarization of mitochondrial membrane potential (MMP). Intriguingly, Mdr1 was significantly upregulated in mitochondria but not in cell membrane. The upregulated mitochondrial Mdr1 was reversed by treatment with carbonyl cyanide m‐chlorophenyl hydrazone, an MMP depolarization inducer. Furthermore, apoptosis and autophagy were increased in multidrug resistance protein 1 knockout HMM cells cultured under glucose starvation with metformin treatment. The data suggest that mitochondrial Mdr1 plays a critical role in the chemoresistance to metformin in HMM cells, which could be a potential target for improving its therapeutic efficacy. 相似文献
4.
Breanne E. Kunstler Jill L. Cook Joanne L. Kemp Paul D. O’Halloran Caroline F. Finch 《Journal of Science and Medicine in Sport》2019,22(1):2-10
Objectives
To determine: (i) the behaviour change techniques used by a sample of Australian physiotherapists to promote non-treatment physical activity; and (ii) whether those behaviour change techniques are different to the techniques used to encourage adherence to rehabilitation exercises.Design
Cross-sectional survey.Method
An online self-report survey was advertised to private practice and outpatient physiotherapists treating patients with musculoskeletal conditions. The use of 50 behaviour change techniques were measured using five-point Likert-type scale questions.Results
Four-hundred and eighty-six physiotherapists responded to the survey, with 216 surveys fully completed. Most respondents (85.1%) promoted non-treatment physical activity often or all of the time. Respondents frequently used 29 behaviour change techniques to promote non-treatment physical activity or encourage adherence to rehabilitation exercises. A similar number of behaviour change techniques was frequently used to encourage adherence to rehabilitation exercises (n = 28) and promote non-treatment physical activity (n = 26). Half of the behaviour change techniques included in the survey were frequently used for both promoting non-treatment physical activity and encouraging adherence to rehabilitation exercises (n = 25). Graded tasks was the most, and punishment was the least, frequently reported technique used to promote non-treatment physical activity and encourage adherence to rehabilitation exercises.Conclusions
Respondents reported using similar behaviour change techniques to promote non-treatment physical activity and encourage adherence to rehabilitation exercises. The variability in behaviour change technique use suggests the behaviour the physiotherapist is promoting influences their behaviour change technique choice. Including the frequently-used behaviour change techniques in non-treatment physical activity promotion interventions might improve their efficacy. 相似文献5.
6.
7.
8.
9.