全文获取类型
收费全文 | 5060篇 |
免费 | 278篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 214篇 |
妇产科学 | 62篇 |
基础医学 | 632篇 |
口腔科学 | 46篇 |
临床医学 | 284篇 |
内科学 | 1618篇 |
皮肤病学 | 93篇 |
神经病学 | 396篇 |
特种医学 | 122篇 |
外科学 | 683篇 |
综合类 | 15篇 |
预防医学 | 105篇 |
眼科学 | 95篇 |
药学 | 308篇 |
中国医学 | 15篇 |
肿瘤学 | 631篇 |
出版年
2024年 | 8篇 |
2023年 | 46篇 |
2022年 | 96篇 |
2021年 | 150篇 |
2020年 | 87篇 |
2019年 | 118篇 |
2018年 | 129篇 |
2017年 | 117篇 |
2016年 | 137篇 |
2015年 | 130篇 |
2014年 | 155篇 |
2013年 | 213篇 |
2012年 | 337篇 |
2011年 | 399篇 |
2010年 | 230篇 |
2009年 | 182篇 |
2008年 | 313篇 |
2007年 | 326篇 |
2006年 | 336篇 |
2005年 | 347篇 |
2004年 | 321篇 |
2003年 | 308篇 |
2002年 | 271篇 |
2001年 | 56篇 |
2000年 | 48篇 |
1999年 | 54篇 |
1998年 | 59篇 |
1997年 | 55篇 |
1996年 | 36篇 |
1995年 | 38篇 |
1994年 | 50篇 |
1993年 | 51篇 |
1992年 | 27篇 |
1991年 | 27篇 |
1990年 | 13篇 |
1989年 | 18篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1984年 | 6篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1975年 | 6篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1966年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有5394条查询结果,搜索用时 15 毫秒
1.
2.
3.
Daisuke Ishii Daisuke Matsuzawa Shingo Matsuda Haruna Tomizawa-Shinohara Chihiro Sutoh Eiji Shimizu 《The International journal of neuroscience》2019,129(1):1-9
Adolescence is a vulnerable period for developing anxiety-related mental disorders such as post-traumatic stress disorder (PTSD), which requires a long-term course of therapy when a traumatic event has been experienced during childhood. However, the biological mechanism underlying these age-dependent characteristics remains unclear. In the present study, we used early adolescent, late adolescent and adult (4-, 8-, and 15-week old) male mice to examine age differences in fear memory, fear extinction, and spontaneous recovery of fear. We also measured the activation of extracellular signal-regulated kinase (ERK) 2 in the dorsal hippocampus (dHip) and the basolateral amygdala (BLA) following a spontaneous recovery test. Our major findings were as follows: (1) early adolescent and adult mice did not recover the fear response; only late adolescent mice recovered the fear response. (2) The ERK2 in the dHip was more activated after the spontaneous recovery test in late adolescent mice than in adult mice, and the ERK2 in the BLA was more activated after the spontaneous recovery test in adult mice than in late adolescent mice. These results suggest that there exists a unique period in which spontaneous recovery occurs and that these late adolescent behavioral signatures may be related to alteration in the ERK2 phosphorylation in the dHip and BLA. 相似文献
4.
5.
The association of MTHFR and CBS variants with the doubling time and responsiveness to several chemodrugs was analyzed in 26 human cancer xenografts. The tumors homozygous for the absence of insertion (NN) for the CBS 844ins68bp were more chemosensitive than those with insertion (NI) to TS-1 (P=0.0048), suggesting a potential effect of this variant on fluoropyrimidine efficacy. Furthermore, the doubling time of tumors with a variant C allele (AC or CC) in MTHFR-A1298C was significantly longer than that of tumors with a normal allele (AA) (P=0.0008). Twenty-nine cellular proliferation-related genes were associated with MTHFR-A1298C genotyping and with the doubling time. 相似文献
6.
Tetsuji Kai Yang Il Kim Hirokazu Kitamura Katsunori Kawano Seigo Kitano 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(4):423-430
There is a growing body of evidence that the cytokine, tumor necrosis factor-α (TNF-ga), plays an important role in the development
of hepatic ischemia/reperfusion injury. We found that the immunosuppressants, cyclosporine-A (CsA), azathioprine, and FK506,
have protective effects on such injury. The purpose of the present study was to elucidate mechanisms involved in these beneficial
effects of the immunosuppressant, CsA, on liver injury following cold preservation and transplantation, with special reference
to the suppression of TNF-α release. Rat livers were stored in Euro-Collins solution (EC) at 4°C for 6h and orthotopically
transplanted. The animals allotted to two groups: group A (untreated controls) and group B (CsA pretreatment of recipients).
CsA (10 mg/kg, p.o.) was given for 3 consecutive days preoperatively. CsA pretreatment of the recipients significantly improved
the 2-week survival rate (0/6 for group A, 3/6 for group B;P<0.05) and this was associated with a significant decrease in serum TNF-α levels 2h posttransplantation (group A, 69.8±15.7
pg/ml; group B, 22.8±6.8; mean±SEM;n=12 each;P<0.05) and amelioration of sinusoidal endothelial injury, assessed by electron microscopy. Plasma endotoxin levels following
reperfusion of the grafts were not altered by the CsA therapy. Morphologically, CsA pretreatment of the recipients did not
alter activation of Kupffer cells. CsA pretreatment of the recipient aids in preventing cold preservation/reperfusion injury
of the liver graft, possibly by modulating effects of TNF-α. 相似文献
7.
Akihiro Hosaka M.D. Tetsuro Miyata M.D. Hiroshi Shigematsu M.D. Jun-o Deguchi M.D. Hideo Kimura M.D. Hirokazu Nagawa M.D. Osamu Sato M.D. Takehiko Sakimoto M.D. Tomoyuki Mochizuki M.D. 《Journal of gastrointestinal surgery》2006,10(4):583-585
The vascular type of Ehlers-Danlos syndrome is a genetic disorder of connective tissue and is frequently associated with catastrophic
arterial complications. Its surgical treatment is extremely difficult because of the fragility of vessels. This article describes
three patients with vascular type of Ehlers-Danlos syndrome who developed mesenteric hemorrhage due to spontaneous arterial
rupture. The clinical and molecular characteristics of the disease are briefly reviewed. 相似文献
8.
9.
Yasuyuki Kato Satoru Miyamoto Hirokazu Minamimura Takumi Ishikawa Kensuke Ohue Yoshihiro Shimizu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(1):46-48
In embryology, a persistent connection of the left superior vena cava to the left atrium rarely coexists with a coronary sinus.
We herein report an unusual case of persistent left superior vena cava terminating in a left atrium with normal coronary sinus,
which was revealed at the time of permanent pacemaker implantation after a second operation for recurrent left atrioventricular
valve regurgitation. Because this anomaly had gone undiagnosed at the first operation, we were unable to diagnose it prior
to the second operation, because the preoperative coronary angiogram clearly demonstrated a coronary sinus that was not dilated.
We would have repaired the anomaly using a patch or other procedure had it been diagnosed before the second operation in order
to prevent cyanosis or brain complications secondary to right-to-left shunting. One should always be on guard for this rare
condition. 相似文献
10.
Atsushi Hirayama Hiroyuki Miyakawa Toshihiro Suga Tatsuya Nagakawa Takahiro Matsunaga Keiya Okamura Hirokazu Oohashi Tomonori Anpo Takashi Hasegawa 《Digestive endoscopy》2006,18(2):147-150
Recently, a self‐expandable metallic stent has been recognized for treatment of malignant duodenal stenosis. But the complications by stenting are important problems even now. In the present study, we report our new method of duodenal stenting by using of double‐balloon enteroscopy considered safe and effective. 相似文献