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Acharyya Rabindra Nath Mithila Shuvra Rani Suborna Islam Md. Arman Golder Mimi Ahmed Khondoker Shahin Hossain Hemayet Dev Shrabanti Das Asish Kumar 《Proceedings of the National Academy of Sciences, India. Section B.》2023,93(1):147-158
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Lumnitzera racemosa a mangrove plant locally used to treat asthma, diabetes, herpes and hypertension. Present... 相似文献
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Shubhra Kanti Dey Arpona Hira Md. Sariful Islam Howlader Arif Ahmed Hemayet Hossain Ismet Ara Jahan 《Pharmaceutical biology》2014,52(2):213-220
Context: Ardisia elliptica Thunb Lam. (Myrsinaceae) is widely used traditionally in the treatment of diarrhea related health disorders in Bangladesh.Objective: The crude ethanol extract of Ardisia elliptica fruits (EFA) was evaluated for its antioxidant and antidiarrhoeal activities.Materials and methods: DPPH radical scavenging, nitric oxide scavenging, reducing power and Fe++ ion chelating ability were used for determining antioxidant activities and animal models were used for antidiarrheal activities such as the castor oil and magnesium sulfate-induced diarrhea, enteropooling induced by the administration of castor oil and magnesium sulfate at the doses of 250 and 500?mg/kg.Results: The extract possessed a significant DPPH free radical scavenging activity with an IC50 value of 30.75?μg/ml compared to ascorbic acid (IC50: 7.89?μg/ml). The IC50 values of the extract and ascorbic acid were 51.72 and 38.68?μg/ml, respectively, in nitric oxide scavenging assay. The IC50 value of the extract for Fe++ ion chelating ability (41.30?μg/ml) was also found to be significant compared to the IC50 value of EDTA (22.57?μg/ml). The EFA also showed a significant protection (p?0.001) against experimentally induced diarrhea by castor oil and magnesium sulfate as evidenced by a decrease in the number of defecation with respect to control. The diarrhea induced by castor oil and magnesium sulfate enteropooling was prevented by all the tested doses.Conclusion: Therefore, the obtained results confirm the antioxidant and antidiarrheal activity of EFA and thus support the traditional uses of this plant as a modality for antioxidant and antidiarrheal activity. 相似文献
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Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone 总被引:1,自引:0,他引:1
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Storey NM Gentile S Ullah H Russo A Muessel M Erxleben C Armstrong DL 《Proceedings of the National Academy of Sciences of the United States of America》2006,103(13):5197-5201
Many nuclear hormones have physiological effects that are too rapid to be explained by changes in gene expression and are often attributed to unidentified or novel G protein-coupled receptors. Thyroid hormone is essential for normal human brain development, but the molecular mechanisms responsible for its effects remain to be identified. Here, we present direct molecular evidence for potassium channel stimulation in a rat pituitary cell line (GH(4)C(1)) by a nuclear receptor for thyroid hormone, TRbeta, acting rapidly at the plasma membrane through phosphatidylinositol 3-kinase (PI3K) to slow the deactivation of KCNH2 channels already in the membrane. Signaling was disrupted by heterologous expression of TRbeta receptors with mutations in the ligand-binding domain that are associated with neurological disorders in humans, but not by mutations that disrupt DNA binding. More importantly, PI3K-dependent signaling was reconstituted in cell-free patches of membrane from CHO cells by heterologous expression of human KCNH2 channels and TRbeta, but not TRalpha, receptors. TRbeta signaling through PI3K provides a molecular explanation for the essential role of thyroid hormone in human brain development and adult lipid metabolism. 相似文献
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