全文获取类型
收费全文 | 2049篇 |
免费 | 134篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 80篇 |
妇产科学 | 30篇 |
基础医学 | 285篇 |
口腔科学 | 67篇 |
临床医学 | 174篇 |
内科学 | 357篇 |
皮肤病学 | 63篇 |
神经病学 | 111篇 |
特种医学 | 266篇 |
外科学 | 292篇 |
综合类 | 40篇 |
一般理论 | 1篇 |
预防医学 | 117篇 |
眼科学 | 43篇 |
药学 | 128篇 |
肿瘤学 | 142篇 |
出版年
2022年 | 9篇 |
2021年 | 26篇 |
2020年 | 10篇 |
2019年 | 17篇 |
2018年 | 23篇 |
2017年 | 23篇 |
2016年 | 16篇 |
2015年 | 28篇 |
2014年 | 45篇 |
2013年 | 60篇 |
2012年 | 50篇 |
2011年 | 73篇 |
2010年 | 61篇 |
2009年 | 73篇 |
2008年 | 71篇 |
2007年 | 87篇 |
2006年 | 88篇 |
2005年 | 86篇 |
2004年 | 67篇 |
2003年 | 54篇 |
2002年 | 60篇 |
2001年 | 75篇 |
2000年 | 55篇 |
1999年 | 47篇 |
1998年 | 63篇 |
1997年 | 57篇 |
1996年 | 53篇 |
1995年 | 45篇 |
1994年 | 39篇 |
1993年 | 40篇 |
1992年 | 41篇 |
1991年 | 39篇 |
1990年 | 45篇 |
1989年 | 53篇 |
1988年 | 45篇 |
1987年 | 80篇 |
1986年 | 51篇 |
1985年 | 46篇 |
1984年 | 29篇 |
1983年 | 31篇 |
1982年 | 24篇 |
1981年 | 26篇 |
1980年 | 20篇 |
1979年 | 23篇 |
1978年 | 16篇 |
1977年 | 13篇 |
1976年 | 27篇 |
1975年 | 13篇 |
1974年 | 7篇 |
1972年 | 7篇 |
排序方式: 共有2208条查询结果,搜索用时 0 毫秒
1.
2.
Krishna K. Singh Yuxin Dong John T. Belisle Jeffrey Harder Vijay K. Arora Suman Laal 《Clinical and Vaccine Immunology : CVI》2005,12(2):354-358
Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of ~12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 [88]-kDa malate synthase [GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (~90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB. 相似文献
3.
J M Rothenbühler C Beglinger B Meyer A Marx F Harder G Stalder 《Helvetica chirurgica acta》1990,56(6):917-920
Alternative techniques were introduced in the last 20 years for the treatment of gallstones. Among these the extracorporeal shock wave lithotripsy followed by a systemic litholytic therapy represents undoubtedly the most attractive one. A group of two surgeons and two gastroenterologists has started to evaluate this treatment in April 1988, using a piezoceramic lithotryptic system (Piezolith 2300). From April 1988 to May 1989 we have treated 32 patients who fulfilled the selection criteria-symptomatic gallstone disease, 1-3 radiolucent concrements of less than 30 mm of diameter, functioning gallbladder. We noted only one pancreatitis as a complication of this treatment. The overall stonefree rate is 16% after two months, 32% after four months and 56% after six months, depending on the size and number of stones. A definitive evaluation and final conclusion will only be possible when the rate of late recurrences after this treatment will be known. 相似文献
4.
Harvesting the rectus abdominis myocutaneous flap results in defects in both the rectus abdominis muscle and the anterior rectus sheath, which may be circumvented by dissecting a perforator flap (DIEP flap) instead. However, the latter is associated with a reduction in the number of myocutaneous perforators nourishing the flap, which has been hypothesised to lead to an increased risk of partial flap failure. We present a technical modification that maintains all the feeding perforators within the flap while fully preserving the anterior rectus sheath. The anterior rectus sheath is incised along a line connecting the perforators. A muscle cuff including all the feeding perforators was raised with the flap. This technique was used in 20 consecutive patients. Nine patients underwent free TRAM flap transfers for breast reconstruction (10 flaps), and 11 patients underwent thoracic-wall reconstruction with a superiorly based pedicled flap. The median follow-up was 11 months. One patient with a pedicled flap developed a partial failure that required surgical revision; all other flaps healed spontaneously. One patient in each subset had preoperative abdominal-wall laxity that was partly corrected after surgery; no abdominal bulging or hernia occurred in the other patients. Our results suggest that the technical modification presented here may enable the surgeon to dissect a rectus abdominis myocutaneous flap with maximal perforator-related flap perfusion and minimal donor-site morbidity. An advantage over the DIEP flap is that this technique is applicable to both free and pedicled flaps. 相似文献
5.
6.
Ralls PW; Johnson MB; Kanel G; Dobalian DM; Colletti PM; Boswell WD Jr; Radin DR; Halls JM 《Radiology》1986,161(2):451-454
FM sonography - a signal-processing technique that uses frequency and phase information as well as amplitude data - shows promise in evaluation of patients with diffuse liver disease. In a prospective blinded review of 37 patients with biopsy-proved liver disease and 42 healthy volunteers, FM sonography was clearly superior to traditional amplitude-based (AM) sonography in distinguishing healthy from diseased subjects. Statistically significant differences were seen in accuracy (FM, 98.7%; AM, 84.8%), sensitivity (FM, 97.3%; AM, 70.3%), and negative predictive value (FM, 97.7%; AM, 78.8%). Our data also suggest that current FM sonographic techniques cannot differentiate among histologic findings associated with different hepatic parenchymal abnormalities. It is unclear, therefore, whether FM imaging can reduce the numbers of patients who require biopsy for diagnosis or the frequency of biopsy procedures in patients with known disease. 相似文献
7.
8.
E Walther R Hünig F Harder U Laffer A C Almendral H Dieterich J P Obrecht J Torhorst J Roth 《Helvetica chirurgica acta》1992,59(1):175-179
353 patients with stages pTis, pT1-2, pN0-1, cM0 breast cancer have been treated consecutively by breast conserving therapy in a prospective, nonrandomized study at the University Hospital Basel and the Women's Clinic Rheinfelden/Baden/Germany. The median age was 47 years, the median follow-up time 67 months, and 4% only of this collective were lost to follow-up after a median time of 42 months. In 79% of the cases the tumor was excised totally, while in 19% the resection margins were positive and in 2% only the margins were not available for histological judgement. The rate of local failure reached 8% with a median time interval of 53 months. 116 patients showed postactinic induration in the primary tumor region. 73 of these were given additional diagnostic examination: The postactinic induration was judget clinically suspicious in 51 cases and clinically nonsuspicious of local failure in 22 cases. All 73 patients received additional examination by mammography and biopsy. By comparison with the histological results the clinical results were correct in 59% and false in 41%, while the mammographic results were correct in 82% and false in 18% of the cases. 相似文献
9.
Yoshimitsu Kuroyanagi DR. ENG DR. SCI DR. MED ; Akihiko Shiraishi MD ; Yoshiteru Shirasaki MD ; Nobuaki Nakakita MD ; Yoshiaki Yasutomi MD ; Yasuo Takano MD ; Nobuyuki Shioya MD FACS 《Wound repair and regeneration》1994,2(2):122-129
A bilaminar wound dressing composed of an outer membrane and an inner three-dimensional matrix of a fabric or a sponge may be considered to constitute an ideal structure that promotes wound healing: the outer membrane prevents body fluid loss, controls water evaporation, and protects the wound surface from bacterial invasion, and the inner matrix encourages adherence by tissue growth into the matrix. Using this concept, we developed a biosynthetic wound dressing with a drug delivery capability. This medicated wound dressing is composed of a spongy sheet of a chitosane derivative and collagen mixture that is laminated to an antimicrobial-impregnated polyurethane membrane. In this study, a gentamycin sulfate-impregnated wound dressing was prepared and evaluated. The antimicrobial efficacy of this wound dressing was examined on an agar plate seeded with Pseudomonas aeruginosa. Also, the cytotoxicity of an antimicrobial released from this wound dressing was examined in an in vitro system with cultured skin substitutes. Both in vitro tests have shown that this wound dressing is capable of suppressing bacterial growth and minimizing cellular damage. In addition, in the treatment of wounds inflicted on rats and rabbits, this wound dressing was shown to be efficacious in covering full-thickness and split-thickness skin defects. Finally, the efficacy of this wound dressing was evaluated in a nonrandomized open-label study of 31 clinical cases. In 31 cases treated with this wound dressing, good or excellent wound healing was achieved. 相似文献
10.
DR Foster 《Journal of Medical Imaging and Radiation Oncology》1995,39(4):399-400
The use of self-expanding prostheses in the management of malignant oesophageal strictures has become well established. The majority of benign peptic oesophageal strictures can be successfully managed using endoscopic or fluoroscopically guided balloon oesophageal dilatation combined with long-term drug therapy, particularly using proton pumper inhibitors. Although endoscopic oesophageal dilatation can be performed on an outpatient basis, it requires repeated hospital visits. There is a small risk of oesophageal perforation whilst cardio-respiratory complications may be encountered during the use of intravenous sedation in an elderly population. The use of a self-expanding Strecker stent in a 98 year old woman with a benign oesophageal stricture is described. 相似文献