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Clinical or chemical (latent) diabetes was discovered in 7 of 8 patients with generalized granuloma annulare; all were women. The average age of onset of their disease was 50 years. Treatment with chlorpropamide and low carbohydrate diet seemed to alleviate the skin manifestations in 6 of 7 patients so treated. 相似文献
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HAIM E 《Zentralblatt für Chirurgie》1957,82(37):1557-1563
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We determined the occurrence of antineutrophil cytoplasmic antibodies(ANCAs) and their specificities in 77 rheumatoid arthritis (RA)patients and compared them with 25 patients with psoriatic arthritis(Pso), 19 with drug-induced lupus erythematosus (DI-LE) and11 with systemic lupus erythematosus (SLE). Thirty-two per centof RA patients had positive indirect immunofluorescence (IIF)stains (P or atypical ANCA). Twenty-nine per cent of patientswith rheumatoid vasculitis (RAV), 48% with long-standing RA(LSRA) and 20% with early RA (Ely RA) had positive ANCAs comparedwith 4% of Pso patients, 47% of DI-LE patients and 45% of SLEpatients. Western blotting (with polymorphonuclear cell extractsor alpha-granules) and alpha-granule enzyme-linked immunosorbentassay (ELISA) yielded variable results and proved unhelpfulfor characterizing the specificities of ANCAs. ELISAs basedon commercial purified lactoferrin (LF), myeloperoxidase (MPO),human elastase (HLE) and cathepsin G (CG) showed that anti-HLEantibody was the most prevalent (14%) antibody in RA, followedby anti-MPO antibody and anti-LF antibody (10% each). Statisticalanalysis of antibody prevalence by clinical presentation showedthat LSRA patients were more likely to have anti-HLE antibodyand that DI-LE patients were more likely to have anti-CG antibodycompared with the other patient groups. In lupus patients serialELISA titration of ANCAs (LF and MPO) was found to be reliablefor predicting the outcome. The overall incidence of ANCAs inRA patients was 33% by IIF. KEY WORDS: Rheumatoid arthritis, Antineutrophil cytoplasmic antibodies, Rheumatoid vasculitis, Systemic lupus erythematosus, Drug-induced lupus, Psoriatic arthritis 相似文献
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Use of New Imaging CARTO® Segmentation Module Software to Facilitate Ablation of Ventricular Arrhythmias 下载免费PDF全文
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HAIM J 《Vojnosanitetski pregled. Military-medical and pharmaceutical review》1954,11(3-4):122-125
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