睡眠重叠综合征患者发生肺动脉高压的相关因素调查

目的 调查睡眠重叠综合征（overlap syndrome,OS）患者肺动脉高压（pulmonary hypertension,PH）发病的独立相关因素。方法 调查2019年1月至2020年1月在首都医科大学附属北京安贞医院呼吸与危重症医学科就诊的128名患者。检测肺功能诊断慢性阻塞性肺疾病（以下简称慢阻肺）;采用睡眠监测识别睡眠呼吸事件且呼吸暂停低通气指数（apnea-hypopnea index,AHI）≥ 5次/h的患者诊断阻塞性睡眠呼吸暂停（obstructive sleep apnea,OSA）。同时符合慢阻肺和OSA的患者诊断为OS。校正年龄、性别和体质量指数后,使用多元逐步Logistic回归模型分析PH发病的独立相关因素。结果 与单纯OSA和单纯慢阻肺患者相比,OS患者最低血氧饱和度（79% vs 82%和90%,P<0.001）和平均血氧饱和度（92% vs 93%和95%,P<0.001）显著偏低;睡眠血氧饱和度低于90%所占整夜睡眠百分比（11% vs 6%和0%,P<0.001）显著偏高。第一秒用力肺活量（forced expiratory volume in the first second,FEV₁）低于80%预计值的患者发生PH概率是对照患者的2.78倍（OR 2.78,95%CI 1.05~7.38,P=0.040）,AHI ≥ 15次/h的患者PH发生的概率是AHI<15次/h患者的3.46倍（OR 3.46,95%CI 1.02~11.71,P=0.046）。校正年龄、性别和体质量指数等混杂因素后,FEV₁ <80%预计值的患者发生PH概率是对照患者的3.57倍（OR 3.57,95%CI 1.20~10.62,P=0.022）。结论 肺通气功能下降是OS患者发生PH的独立相关因素。需要进一步研究气道正压通气等干预能否降低PH的严重程度并改善患者的长期预后。     

Synthesis and photocatalytic CO2 reduction performance of aminated coal-based carbon nanoparticles

To obtain high-efficiency, low-cost, environmentally friendly carbon-based photocatalytic material, we synthesized coal-based carbon dots with sp² carbon structure and multilayer graphene lattice structure by the hydrogen peroxide (H₂O₂) oxidation method to strip nano-scale crystalline carbon in the coal structure and link with oxygen-containing groups such as the hydroxyl group. N, S co-doped aminated coal-based carbon nanoparticles (NH₂-CNPs) were then obtained by thionyl chloride chlorination and ethylenediamine passivation. The physical properties and chemical structure of the synthesized NH₂-CNPs were studied and the photocatalytic CO₂ reduction performance was tested. The results show that NH₂-CNPs are vesicle-type spherical particles with particle size of 42.16 ± 7.5 nm and have a mesoporous structure that is capable of adsorbing CO₂. A defect structure was formed on the surface of the NH₂-CNPs due to the doping of N and S elements, thereby significantly improving the ability to photogenerate electrons under visible light along with the ability to efficiently separate the photo-generated carriers. The photocatalytic reduction products of CO₂ over NH₂-CNPs were CH₃OH, CO, C₂H₅OH, H₂ and CH₄. After 10 hours of reaction, the total amount of products was 807.56 μmol g⁻¹ cat, the amount of CH₃OH was 618.7 μmol g⁻¹ cat, and the calculated selectivity for conversion of CO₂ to CH₃OH was up to 76.6%.

Aminated coal-based carbon nanoparticles (NH₂-CNPs) was fabricated. The physical properties and chemical structure of the NH₂-CNPs was studied. Photocatalytic CO₂ reduction activity of NH₂-CNPs were measured and the reaction mechanism was discussed.     

哨兵动物口蹄疫抗体及病原学检测报告

2013年哨兵动物口蹄疫抗体及病原学检测结果表明,哨兵动物群体中不存在口蹄疫病畜或健康带毒畜,但是群体口蹄疫免疫抗体水平不高,需要强化免疫。     

泰勒焦虫表面抗原TaSP、spag-1和Tams-1基因片段克隆与序列分析

为了解泰勒焦虫表面抗原基因特性，利用PCR方法对实验室保存的泰勒焦虫细胞表面抗原spag-1、Tamsl和TaS部分基因片段进行克隆与序列分析。PCR结果显示所扩增的spag—1、Tamsl和TaSP部分基因长度分别为372bp，324bp和321bp。系统发育树分析表明，与本次测序表面抗原TaSP和Tamsl基因片段同源性最高的虫株登录号分别为FJ895154和AF214797的泰勒焦虫株，同源性分别高达100％与99．69％；与spag-1基因片段同源性最高的虫株登录号为X78188、XM949884和M63017，它们之间同源性为100％。     

儿童严重脊柱侧凸的生长阀双棒内固定治疗

目的探讨早发的儿童严重脊柱侧凸采用生长阀双棒内固定治疗的临床疗效。方法选择2006年11月~2011年3月我科收治入院的早发的严重脊柱侧凸儿童10例临床资料进行回顾性分析,10例患儿中9例采用lsola生长阀固定,1例采用TSRH生长阀固定;撑开1~4次,平均1.8次;随访10~24个月,平均(15.2±2.5)个月。结果术前主弯Cobb角(67.64±11.43)°,胸后凸(31.00±22.40)°,躯干偏移(2.00±1.43)cm,T1~S1高度(25.47±6.16)cm;初次术后主弯Cobb角(34.64±8.26)°,胸后凸(23.00±8.06)°,躯干偏移(1.49±1.21)cm,T1~S1高度(28.84±5.69)cm;末次术后主弯Cobb角(36.82±11.76)°,胸后凸(27.18±8.97)°,躯干偏移(1.11±0.29)cm,T1~S1高度(31.29±4.50)cm。术前、初次术后和末次术后主弯侧凸角比较差异有统计学意义(P<0.05)。初次手术矫正率(47.15±16.48)%,T1~S1高度增加(3.37±1.62)cm;末次手术矫正率(44.73±19.43)%,T1~S1高度增加(5.82±2.21)cm。治疗期间T1~S1每年平均生长1.6 cm(1.1~2.7 cm)。5例出现并发症(3例脱钩,1例椎弓根螺钉脱出,1例断棒)。结论生长阀双棒内固定技术允许脊柱纵向生长,同时起到矫形和控制畸形发展的作用,但术后并发症发生率较高。     

新疆曼陀罗子炮制品一般毒性研究

目的 探讨新疆曼陀罗子生品维吾尔医药学炮制及其炮制品的毒性.方法 维吾尔医药学炮制法制备新疆曼陀罗子炮制品.选用小鼠对新疆曼陀罗子炮制品进行急性毒性及亚急性毒性试验.结果 小鼠对新疆曼陀罗子炮制品最大耐受剂量为32 g（生药）/kg.与对照组比较,新疆曼陀罗子炮制品组第2天血清AST含量升高（P〈0.05）;第7天、第14天（雄性）小鼠血清ALT含量升高（P〈0.05,P〈0.01）;第2天、第7天、第14天（雌性）小鼠血清BUN含量降低（P〈0.05～P〈0.01）;第2天（雌性）、第7天小鼠血清CRE含量降低（P〈0.05～P〈0.01）.结论 维吾尔医药学炮制方法处理新疆曼陀罗子（生品）能降低其毒性.