全文获取类型
收费全文 | 3830篇 |
免费 | 236篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 124篇 |
妇产科学 | 82篇 |
基础医学 | 623篇 |
口腔科学 | 40篇 |
临床医学 | 368篇 |
内科学 | 983篇 |
皮肤病学 | 75篇 |
神经病学 | 457篇 |
特种医学 | 76篇 |
外科学 | 295篇 |
综合类 | 6篇 |
预防医学 | 156篇 |
眼科学 | 37篇 |
药学 | 315篇 |
中国医学 | 2篇 |
肿瘤学 | 425篇 |
出版年
2023年 | 18篇 |
2022年 | 62篇 |
2021年 | 97篇 |
2020年 | 56篇 |
2019年 | 80篇 |
2018年 | 85篇 |
2017年 | 74篇 |
2016年 | 93篇 |
2015年 | 99篇 |
2014年 | 154篇 |
2013年 | 182篇 |
2012年 | 303篇 |
2011年 | 324篇 |
2010年 | 181篇 |
2009年 | 150篇 |
2008年 | 246篇 |
2007年 | 264篇 |
2006年 | 232篇 |
2005年 | 250篇 |
2004年 | 210篇 |
2003年 | 209篇 |
2002年 | 190篇 |
2001年 | 34篇 |
2000年 | 29篇 |
1999年 | 29篇 |
1998年 | 55篇 |
1997年 | 33篇 |
1996年 | 28篇 |
1995年 | 34篇 |
1994年 | 15篇 |
1993年 | 11篇 |
1992年 | 23篇 |
1991年 | 16篇 |
1990年 | 22篇 |
1989年 | 16篇 |
1988年 | 14篇 |
1987年 | 19篇 |
1986年 | 16篇 |
1985年 | 11篇 |
1984年 | 15篇 |
1983年 | 16篇 |
1982年 | 12篇 |
1981年 | 6篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1973年 | 5篇 |
1971年 | 5篇 |
1970年 | 6篇 |
1969年 | 5篇 |
1966年 | 6篇 |
排序方式: 共有4086条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Fabio Frosio Federico Mocchegiani Grazia Conte Enrico Dalla Bona ANDrea Vecchi Daniele Nicolini Marco Vivarelli 《World journal of gastrointestinal surgery》2019,(6)
Cholangiocarcinoma(CCA) is a malignant tumor of the biliary system and includes, according to the anatomical classification, intra hepatic CCA(iCCA),hilar CCA(hCCA) and distal CCA(dCCA). Hilar CCA is the most challenging type in terms of diagnosis, treatment and prognosis. Surgery is the only treatment possibly providing long-term survival, but only few patients are considered resectable at the time of diagnosis. In fact, tumor's extension to segmentary or subsegmentary biliary ducts, along with large lymph node involvement or intrahepatic metastases, precludes the surgical approach. To achieve R0 margins is mandatory for the disease-free survival and overall survival. In case of unresectable locally advanced hCCA, radiochemotherapy(RCT) as neoadjuvant treatment demonstrated to be a therapeutic option before either hepatic resection or liver transplantation. Before liver surgery, RCT is believed to enhance the R0 margins rate. For patients meeting the Mayo Clinic criteria, RCT prior to orthotopic liver transplant(OLT) has proved to produce acceptable 5-years survivals. In this review, we analyze the current role of neoadjuvant RCT before resection as well as before OLT. 相似文献
5.
Rocco Spagnuolo Alessandro Corea Mariantonietta Blumetti Alessia Giovinazzo Massimiliano Serafino Caterina Pagliuso Raffaele Pagnotta Grazia Curto Cristina Cosco Vincenzo Cosco Rosellina Margherita Mancina Pietro Garieri Anna Papaleo Laura Grande Anna Barilaro Eugenio Garofalo Andrea Bruni Patrizia Doldo 《Journal of advanced nursing》2020,76(11):2993-3002
6.
Paolo Mazzone Fabrizio Stocchi Salvatore Galati Angelo Insola Maria Grazia Altibrandi Nicola Modugno Domenicantonio Tropepi Livia Brusa Alessandro Stefani 《Neuromodulation》2006,9(3):221-228
Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l ‐dopa–induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. Materials and Methods. The routine utilization of our innovative stereotactic apparatus allows us to implant, at the same time, both the CM‐Pf complex together with the GPi in six Parkinson disease patients. Both intraoperative and postoperative neurophysiologic assessments helped us recognize functional subregions while optimizing implantation of electrodes. Unified Parkinson disease rating scale (UPDRS) motor scores, AIMs, and freezing were carefully blindly evaluated for each condition. Results. A significant amelioration of UPDRS scores was achieved by simultaneous activation of both targets. CM‐Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro‐catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit. 相似文献
7.
8.
Antinori Andrea Cingolani Antonella Lorenzini Patrizia Giancola Maria Letizia Uccella Ilaria Bossolasco Simona Grisetti Susanna Moretti Francesca Vigo Beniamino Bongiovanni Marco Del Grosso Bruno Arcidiacono Maria Irene Fibbia Giovanni Carlo Mena Maurizio Finazzi Maria Grazia Guaraldi Giovanni Ammassari Adriana Monforte Antonella dArminio Cinque Paola De Luca Andrea 《Journal of neurovirology》2003,9(1):47-53
Human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML) remains a relevant clinical problem even in the era of highly active antiretroviral therapy (HAART). Aims of the study were to analyze clinical and treatment-related features and the survival probability of PML patients observed within the Italian Registry Investigative Neuro AIDS (IRINA) during a 29-month period of HAART. Intravenous drug use, the presence of focal signs, and the involvement of white matter at neuroradiology increased the risk of having PML. A reduced probability of PML was observed when meningeal signs were reported. Patients starting HAART at PML diagnosis and previously naïve for antiretrovirals showed significantly higher 1-year probability of survival (.58), compared to those continuing HAART (.24), or never receiving HAART (.00). Higher CD4 cell count were associated with a higher survival probability (.45). At multivariate analysis, a younger age, higher CD4, starting HAART at PML diagnosis, the absence of previous acquired immunodeficiency syndrome (AIDS)-defining events, and the absence of a severe neurologic impairment were all associated with a reduced hazard of death. The use of cidofovir showed a trend towards a reduced risk of death. 相似文献
9.
Maria Grazia Daidone Rosella Silvestrini Nadia Zaffaroni Egle Grignolio Fabio Landoni 《Investigational new drugs》1987,5(3):245-250
An in vitro assay, which evaluates drug effect on 3H-thymidine incorporation, was used to investigate the absolute and relative activities of cisplatin (DDP), carboplatin (CBDCA) and iproplatin (CHIP) on 317 specimens from untreated tumors, including breast and ovarian cancers and malignant melanomas. Similar activities were generally observed for DDP and CHIP, whereas CBDCA exhibited a lower, although not significantly different cytotoxicity on breast and ovarian cancers. The relative activities of Platinum analogues were analyzed on 239 two-way drug sensitivity comparisons. The overall agreement rates ranged from 80.2 to 83.9% for the different comparisons. High coresistance, from 61.1 to 93.8%, was observed for all the comparisons, regardless of the tumor type. Cosensitivity rates were poor for breast and ovarian cancers, from 0 to 37.5%, whereas for melanomas an association in sensitivity was observed in 80% of the cases. 相似文献
10.
L. Intorre C. Blandizzi G. Natale D. Intorre Grazia Mengozzi G. Soldani 《Autonomic & autacoid pharmacology》1994,14(5):345-352
1 The purpose of the present study was to analyse the effects of the α2-adrenoceptor agonist medetomidine and the antagonist yohimbine on gastrin release in conscious dogs. 2 Gastrin secretion was investigated under both basal conditions and stimulation by 2-deoxy-D-glucose, food or bombesin. 3 Basal gastrin under fasting conditions was significantly reduced by medetomidine and increased by yohimbine. 4 2-deoxy-D-glucose-induced gastrin increase was fully inhibited by medetomidine; this effect was antagonized by yohimbine. 5 Medetomidine significantly inhibited food-induced increase in plasma gastrin; under these conditions yohimbine was without effect per se, but significantly antagonized the inhibitory action of medetomidine. 6 Gastrin release induced by bombesin was not affected by medetomidine or yohimbine. 7 These results suggest that α2-adrenoceptors play an inhibitory role under conditions in which gastrin release is mainly mediated through cholinergic and non-cholinergic nervous pathways; in contrast, they do not indicate the presence of α2-adrenoceptors on G cells of the dog stomach. 相似文献