全文获取类型
收费全文 | 496篇 |
免费 | 45篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 22篇 |
妇产科学 | 29篇 |
基础医学 | 67篇 |
口腔科学 | 24篇 |
临床医学 | 57篇 |
内科学 | 89篇 |
皮肤病学 | 21篇 |
神经病学 | 24篇 |
特种医学 | 24篇 |
外科学 | 100篇 |
综合类 | 3篇 |
预防医学 | 14篇 |
眼科学 | 2篇 |
药学 | 45篇 |
中国医学 | 2篇 |
肿瘤学 | 16篇 |
出版年
2024年 | 3篇 |
2023年 | 19篇 |
2022年 | 21篇 |
2021年 | 48篇 |
2020年 | 36篇 |
2019年 | 31篇 |
2018年 | 34篇 |
2017年 | 26篇 |
2016年 | 31篇 |
2015年 | 23篇 |
2014年 | 19篇 |
2013年 | 25篇 |
2012年 | 36篇 |
2011年 | 34篇 |
2010年 | 8篇 |
2009年 | 19篇 |
2008年 | 20篇 |
2007年 | 31篇 |
2006年 | 17篇 |
2005年 | 9篇 |
2004年 | 7篇 |
2003年 | 17篇 |
2002年 | 7篇 |
2001年 | 11篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1991年 | 1篇 |
1985年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有543条查询结果,搜索用时 31 毫秒
1.
Yıldız Gizem Torun Bayram Meral Soylu Alper Kavukçu Salih 《International urology and nephrology》2021,53(2):391-392
International Urology and Nephrology - 相似文献
2.
Osman Serhat Guner Latif Volkan Tumay 《Asian journal of surgery / Asian Surgical Association》2021,44(6):841-847
BackgroundIn rectal cancer, extramural vascular invasion (EMVI) is the presence of tumour cells in blood vessels outside the muscular layer, which is associated with poor prognosis. Regression of EMVI on MRI following neoadjuvant chemoradiotherapy or its persistence may have prognostic implications.MethodsThis retrospective study included 52 patients with rectal cancer who underwent total mesorectal excision following long-course neoadjuvant chemoradiotherapy (CRT). EMVI assessments were done on previous pelvic MRIs obtained before neoadjuvant CRT and eight weeks after the completion of neoadjuvant chemoradiotherapy in initially EMVI positive cases.ResultsPersistently EMVI positive patients had worse overall survival and disease-free survival compared to initially EMVI negative patients and patients who returned to negative (p < 0.001 for both). Multivariate analysis identified persistent EMVI positivity after neoadjuvant treatment (HR, 102.9; p = 0.003) as significant independent predictor of worse overall survival; and persistent EMVI positivity (HR, 17.0; p = 0.002), mesorectal fascia involvement after neoadjuvant treatment (HR, 8.0; p = 0.017), and poor differentiation (HR, 10.3, p = 0.012) as significant independent predictors of worse disease-free survival.ConclusionPersistent EMVI positivity after neoadjuvant therapy appears to be an independent factor for poor overall survival; and persistent EMVI positivity as well as mesorectal fascia involvement on post neoadjuvant therapy MRI and poor differentiation appears to be important predictors of poor disease-free survival in rectal cancer patients. 相似文献
3.
Gizem Tezel Selin Seda Timur Filiz Kuralay R. Neslihan Gürsoy Kezban Ulubayram Levent Öner 《Journal of drug targeting》2021,29(1):29-45
Abstract Synthetic micro/nanomotors (MNMs) are novel, self-propelled nano or microscale devices that are widely used in drug transport, cell stimulation and isolation, bio-imaging, diagnostic and monitoring, sensing, photocatalysis and environmental remediation. Various preparation methods and propulsion mechanisms make MNMs “tailormade” nanosystems for the intended purpose or use. As the one of the newest members of nano carriers, MNMs open a new perspective especially for rapid drug transport and gene delivery. Although there exists limited number of in-vivo studies for drug delivery purposes, existence of in-vitro supportive data strongly encourages researchers to move on in this field and benefit from the manoeuvre capability of these novel systems. In this article, we reviewed the preparation and propulsion mechanisms of nanomotors in various fields with special attention to drug delivery systems. 相似文献
4.
Cetin Gecmen MD Gonca G. Gecmen MD Muzaffer Kahyaoglu MD Mehmet Aksut MD Nuri Havan MD Ahmet Guner MD Ender O. Cakmak MD Sukran Sarikaya MD Semih Kalkan MD Murat Rabus MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(8):1234-1235
An 83‐year‐old male patient presented to the outpatient clinic with complaint of swelling at right antecubital area. Ultrasonographic examination of the right upper extremity revealed a mass lesion within the right cephalic vein, which was consistent with thrombus. A computed tomography (CT) venography showed contrast enhancement in cephalic vein at distal arm and an aneurysmatic thrombus area displaying regular borders with a size of 28*30 mm; there was no contrast enhancement at more proximal levels at the cephalic vein. 相似文献
5.
Muzaffer Kahyaoglu MD Arzu Kalayci MD Cetin Gecmen MD Munevver Sari MD Ahmet Guner MD Mehmet Celik MD Ibrahim Akin İzgi MD Cevat Kirma MD 《Echocardiography (Mount Kisco, N.Y.)》2018,35(2):258-259
A 42‐year‐old female patient was referred our clinic for investigation of a history of acute retinal artery occlusion. Transthoracic echocardiography showed a cyst‐like, mobile formation on posterior mitral valve leaflet. 2D and real time 3D transesophageal echocardiography showed a flexible circular mobile structure which was attached to posterior mitral valve leaflet. Echocardiographic appearance and morphological characteristics were suggestive of accessory mitral valve tissue. 相似文献
6.
Evaluation of the congenital supravalvular aortic stenosis by different imaging modalities
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ahmet Guner MD Nuri Havan MD Sabahattin Gunduz MD Taylan Akgun MD Busra Guvendi MD Gokhan Kahveci MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(9):1376-1378
A 36‐year‐old female was admitted to hospital exhibiting chest pain, dyspnea, and a heart murmur on the right upper sternal border, radiating to both carotid arteries. The blood pressure of the patient's right arm exceeded the pressure in the left by 25 mm Hg (Coanda effect). In spite of laboratory results that did not fall outside the expected range, the left ventricle was revealed to be hypertrophic following electrocardiography. Transthoracic echocardiography revealed a severe supravalvular aortic stenosis (SVAS) with a peak Doppler velocity of 6.04 cm/s and an estimated mean pressure gradient of 89 mm Hg, with moderate aortic and mitral regurgitation. Contrast‐enhanced computed tomography (CCT) indicated a partial hourglass‐shaped narrowing of the ascending aorta. Lesions associated with supravalvular stenosis of the pulmonary artery, patent ductus arteriosus, and aortic coarctation were ruled out by the CCT. Congenital SVAS is a rare heart condition, and three anatomically distinct forms have been described. The most common type is the “hourglass,” which produces a marked thickening and disorganization of the aortic tissue, producing a constricting annular ridge at the superior margin of the sinuses of Valsalva. 相似文献
7.
Mehmet Rasih Sonsoz Aytac Oncul Erdem Cevik Huseyin Orta Mustafa Yilmaz Elif Ayduk Govdeli Asli Nalbant Zeynep Gizem Demirtakan Mirac Tonyali Damla Durmus Ilkay Anakli Ozlem Polat Yunus Catma Naci Senkal Alpay Medetalibeyoglu Murat Kose Samim Emet Tufan Tukek 《The American journal of the medical sciences》2021,361(5):591-597
BackgroundThe information on electrocardiographic features of patients with coronavirus disease 2019 (COVID-19) is limited. Our aim was to determine if baseline electrocardiographic features of hospitalized COVID-19 patients are associated with markers of myocardial injury and clinical outcomes.MethodsIn this retrospective, single center cohort study, we included 223 hospitalized patients with laboratory-confirmed COVID-19. Clinical, electrocardiographic and laboratory data were collected and analyzed. Primary composite endpoint of mortality, need for invasive mechanical ventilation, or admission to the intensive care unit was assessed.ResultsForty patients (17.9%) reached the primary composite endpoint. Patients with the primary composite endpoint were more likely to have wide QRS complex (>120 ms) and lateral ST-T segment abnormality. The multivariable Cox regression showed increasing odds of the primary composite endpoint associated with acute respiratory distress syndrome (odds ratio 7.76, 95% CI 2.67–22.59; p < 0.001), acute cardiac injury (odds ratio 3.14, 95% CI 1.26–7.99; p = 0.016), high flow oxygen therapy (odds ratio 2.43, 95% CI 1.05–5.62; p = 0.037) and QRS duration longer than >120 ms (odds ratio 3.62, 95% CI 1.39–9.380; p = 0.008) Patients with a wide QRS complex (>120 ms) had significantly higher median level of troponin T and pro-BNP than those without it. Patients with abnormality of lateral ST-T segment had significantly higher median level of troponin T and pro-BNP than patients without.ConclusionsThe presence of QRS duration longer than 120 ms and lateral ST-T segment abnormality were associated with worse clinical outcomes and higher levels of myocardial injury biomarkers. 相似文献
8.
Alibaz-Oner Fatma Ergelen Rabia Ergenc Ilkay Seven Gizem Yazıcı Ayten Cefle Ayse Bes Cemal Atug Ozlen Direskeneli Haner 《Digestive diseases and sciences》2021,66(8):2750-2755
Digestive Diseases and Sciences - Behçet’s disease (BD) and Crohn’s disease (CD) cannot be easily differentiated in young adults presenting with nonspecific gastrointestinal (GI)... 相似文献
9.
Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage‐laden gelatine hydrogels
下载免费PDF全文
![点击此处可从《Journal of tissue engineering and regenerative medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Camille Dollinger Sait Ciftci Helena Knopf‐Marques Rabia Guner Amir M. Ghaemmaghami Christian Debry Julien Barthes Nihal Engin Vrana 《Journal of tissue engineering and regenerative medicine》2018,12(2):330-340
The success of tissue engineering strategy is strongly related to the inflammatory response, mainly through the activity of macrophages that are key cells in initial immune response to implants. For engineered tissues, the presence of resident macrophages can be beneficial for maintenance of homeostasis and healing. Thus, incorporation of macrophages in engineered tissues can facilitate the integration upon implantation. In this study, an in‐vitro model of interaction was developed between encapsulated naive monocytes, macrophages induced with M1/M2 stimulation and incoming cells for immune assisted tissue engineering applications. To mimic the wound healing cascade, naive THP‐1 monocytes, endothelial cells and fibroblasts were seeded on the gels as incoming cells. The interaction was first monitored in the absence of the gels. To mimic resident macrophages, THP‐1 cells were encapsulated in the presence or absence of IL‐4 to control their phenotype and then these hydrogels were seeded with incoming cells. Without encapsulation, activated macrophages induce apoptosis in endothelial cells. Once encapsulated no adverse effects were seen. Macrophage‐laden hydrogels attracted more endothelial cells and fibroblasts compared to monocytes‐laden hydrogels. The induction (M2 stimulation) of encapsulated macrophages did not change the overall number of attracted cells; but significantly affected their morphology. M1 stimulation by a defined media resulted in more secretion of both pro‐ and anti‐inflammatory cytokines compared to M2 stimulation. It was demonstrated that there is a distinct effect of encapsulated macrophages on the behaviour of the incoming cells; this effect can be harnessed to establish a microenvironment more prone to regeneration upon implantation. 相似文献
10.
Uzuner Selcuk Durcan Gizem Sahin Sezgin Bahali Kayhan Barut Kenan Kilicoglu Ali Guven Adrovic Amra Bilgic Ayhan Kasapcopur Ozgur 《Clinical rheumatology》2021,40(12):5025-5032
Clinical Rheumatology - Having a child with a chronic illness is a source of stress for the whole family, especially the primary caregiver. The aim of this study was to evaluate the associations... 相似文献