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排序方式: 共有684条查询结果,搜索用时 15 毫秒
1.
Kristin K Zorn Tomas Bonome Lisa Gangi Gadisetti V R Chandramouli Christopher S Awtrey Ginger J Gardner J Carl Barrett Jeff Boyd Michael J Birrer 《Clinical cancer research》2005,11(18):6422-6430
PURPOSE: The presence of similar histologic subtypes of epithelial ovarian and endometrial cancers has long been noted, although the relevance of this finding to pathogenesis and clinical management is unclear. Despite similar clinical characteristics, histologic subtypes of cancers of the ovary and endometrium are treated according to organ of origin. This study compares the gene expression profiles of analogous histologic subtypes of cancers of the ovary and endometrium using the same genomic platform to determine the similarities and differences between these tumors. EXPERIMENTAL DESIGN: Gene expression profiles of 75 cancers (endometrioid, serous, and clear cell) of the ovary and endometrium, five renal clear cell cancers, and seven normal epithelial brushings were determined using a 11,000-element cDNA array. All images were analyzed using BRB ArrayTools. Validation was done using real-time PCR on select genes and immunohistochemical staining. RESULTS: Comparison across endometrial and ovarian cancers and serous and endometrioid tumors showed expression patterns reflecting their organ of origin. Clear cell tumors, however, showed remarkably similar expression patterns regardless of their origin, even when compared with renal clear cell samples. A set of 43 genes was common to comparisons of each of the three histologic subtypes of ovarian cancer with normal ovarian surface epithelium. CONCLUSIONS: The comparison of the gene expression profiles of endometrioid and serous subtypes of ovarian and endometrial cancer are largely unique to the combination of a particular subtype in a specific organ. In contrast, clear cell cancers show a remarkable similarity in gene expression profiles across organs (including kidney) and could not be statistically distinguished. 相似文献
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Amanda Reiff Metz Matthew Bauer Chelsey Epperly Ginger Stringer Kristen E. Marshall Lindsey Martin Webb Molly Hetherington-Rauth Shannon R. Matzinger Sarah Elizabeth Totten Emily A. Travanty Kristen M. Good Alexis Burakoff 《Emerging infectious diseases》2022,28(8):1551
A COVID-19 outbreak occurred among Cameron Peak Fire responders in Colorado, USA, during August 2020–January 2021. The Cameron Peak Fire was the largest recorded wildfire in Colorado history, lasting August–December 2020. At least 6,123 responders were involved, including 1,260 firefighters in 63 crews who mobilized to the fire camps. A total of 79 COVID-19 cases were identified among responders, and 273 close contacts were quarantined. State and local public health investigated the outbreak and coordinated with wildfire management teams to prevent disease spread. We performed whole-genome sequencing and applied social network analysis to visualize clusters and transmission dynamics. Phylogenetic analysis identified 8 lineages among sequenced specimens, implying multiple introductions. Social network analysis identified spread between and within crews. Strategies such as implementing symptom screening and testing of arriving responders, educating responders about overlapping symptoms of smoke inhalation and COVID-19, improving physical distancing of crews, and encouraging vaccinations are recommended. 相似文献
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Ju-Hyeong Park Eungul Lee Ethan D. Fechter-Leggett Ellie Williams Shobha Yadav Arundhati Bakshi Stefanie Ebelt Jesse E. Bell Heather Strosnider Ginger L. Chew 《Environmental health perspectives》2022,130(8)
Background: Studies of thunderstorm asthma to understand risk factors using high-resolution climate data and asthma outcomes on a large scale are scarce. Moreover, thunderstorm asthma is not well studied in the United States.Objectives: We examined whether climate parameters involved in thunderstorms are associated with emergency department (ED) visits for acute asthma attacks in the United States.Methods: We analyzed 63,789 asthma-related, daily ED visits for all age groups, and thunderstorm-associated climate data in Louisiana during 2010 through 2012. We performed time-series analyses using quasi-Poisson regression models with natural cubic splines of date, parish, holiday, day of week, season, daily maximum concentrations of ozone () and fine particulate matter [PM in aerodynamic diameter ()], and daily mean pressure, precipitation, and temperature. Because of a significant interaction effect between temperature and lightning days on asthma-related visits, we performed stratified analyses by days with/without lightning or thunderstorm (defined by any lightning and precipitation).Results: On thunderstorm days, higher asthma-related ED visits were associated with higher daily mean precipitation [ (95% CI: 1.009, 1.300)] and lower daily mean temperature [ per 1°C change (1.000–1.021)] without carry-over effect to the next non-thunderstorm day. These higher risks were found mainly among children and adults of age. We observed similar results on lightning days. However, we did not find similar associations for non-thunderstorm or non-lightning days. Daily maximum and levels were not significantly associated with asthma ED visits on thunderstorm days.Discussion: Higher precipitation and lower temperature on thunderstorm days appear to contribute to asthma attacks among people with asthma, suggesting they should consider taking precautions during thunderstorms. EDs should consider preparing for a potential increase of asthma-related visits and ensuring sufficient stock of emergency medication and supplies for forecasted severe thunderstorm days. https://doi.org/10.1289/ EHP10440相似文献
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Antigen-presenting cells (APC) play a key role in orchestrating immune responses. T-cell proliferative responses are inhibited during the erythrocyte stages of malaria infection, and a number of studies have suggested that APC are responsible for this phenomenon. In the present studies we examine individual components of the T-cell-activating function of APC: expression of costimulatory and major histocompatibility complex (MHC) class II proteins, the ability to process and present antigen to T cells, and the ability to support cytokine production. We find that during the acute phases of Plasmodium yoelii erythrocyte stage infection, APC upregulate the expression of class II MHC and CD80, maintain expression of CD86, process and present antigen, and support gamma interferon production. However the CD11b(+) subpopulation produces a soluble factor or factors that specifically inhibit interleukin-2 (IL-2) production by responding CD4 T cells. This factor is distinct from prostaglandin E(2), NO, or transforming growth factor beta. The data suggest that IL-2 suppression observed during malaria infection is not due to functional defects of APC but is triggered by production of a factor(s) that actively suppresses production of IL-2 by T cells. 相似文献
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A Randomized Controlled Trial of Team-Based Care: Impact of Physician-Pharmacist Collaboration on Uncontrolled Hypertension 总被引:1,自引:0,他引:1 下载免费PDF全文
Hunt JS Siemienczuk J Pape G Rozenfeld Y MacKay J LeBlanc BH Touchette D 《Journal of general internal medicine》2008,23(12):1966-1972
OBJECTIVE Evaluate the effectiveness of collaborative management of hypertension by primary care-pharmacist teams in community-based
clinics.
STUDY DESIGN A 12-month prospective, single-blind, randomized, controlled trial in the Providence Primary Care Research Network of patients
with hypertension and uncontrolled blood pressure.
METHODS As compared to usual primary care, intervention consisted of pharmacy practitioners participating in the active management
of hypertension in the primary care office according to established collaborative treatment protocols. At baseline, there
was no significant difference in blood pressure between groups. Primary outcome measures were the differences in mean systolic
and diastolic blood pressures between arms at study end. Secondary measures included blood pressure goal attainment (<140/90 mmHg),
hypertension-related knowledge, medication adherence, home blood pressure monitoring, resource utilization, quality of life,
and satisfaction.
RESULTS A total of 463 subjects were enrolled (n = 233 control, n = 230 intervention). Subjects receiving the intervention achieved
significantly lower systolic (p = 0.007) and diastolic (p = 0.002) blood pressures compared to control (137/75 mmHg vs. 143/78 mmHg).
In addition, 62% of intervention subjects achieved target blood pressure compared to 44% of control subjects (p = 0.003).
The intervention group received more total office visits (7.2 vs. 4.9, p < 0.0001), however had fewer physician visits (3.2
vs. 4.7, p < 0.0001) compared to control. Intervention subjects were prescribed more antihypertensive medications (2.7 vs.
2.4, p = 0.02), but did not take more antihypertensive pills per day (2.4 vs. 2.5, p = 0.87). There were minimal differences
between groups in hypertension-related knowledge, medication adherence, quality of life, or satisfaction.
CONCLUSIONS Patients randomized to collaborative primary care-pharmacist hypertension management achieved significantly better blood pressure
control compared to usual care with no difference in quality of life or satisfaction.
The primary author had full access to all of the data in the study and takes responsibility for the integrity of the data
and the accuracy of the data analysis. 相似文献