全文获取类型
收费全文 | 1692篇 |
免费 | 176篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 115篇 |
妇产科学 | 37篇 |
基础医学 | 145篇 |
口腔科学 | 52篇 |
临床医学 | 140篇 |
内科学 | 437篇 |
皮肤病学 | 35篇 |
神经病学 | 52篇 |
特种医学 | 199篇 |
外科学 | 219篇 |
综合类 | 115篇 |
现状与发展 | 1篇 |
一般理论 | 1篇 |
预防医学 | 114篇 |
眼科学 | 47篇 |
药学 | 98篇 |
中国医学 | 5篇 |
肿瘤学 | 89篇 |
出版年
2024年 | 4篇 |
2023年 | 19篇 |
2022年 | 20篇 |
2021年 | 47篇 |
2020年 | 27篇 |
2019年 | 22篇 |
2018年 | 44篇 |
2017年 | 61篇 |
2016年 | 49篇 |
2015年 | 49篇 |
2014年 | 84篇 |
2013年 | 100篇 |
2012年 | 82篇 |
2011年 | 62篇 |
2010年 | 93篇 |
2009年 | 85篇 |
2008年 | 56篇 |
2007年 | 93篇 |
2006年 | 66篇 |
2005年 | 48篇 |
2004年 | 45篇 |
2003年 | 34篇 |
2002年 | 32篇 |
2001年 | 37篇 |
2000年 | 22篇 |
1999年 | 26篇 |
1998年 | 79篇 |
1997年 | 69篇 |
1996年 | 62篇 |
1995年 | 54篇 |
1994年 | 50篇 |
1993年 | 45篇 |
1992年 | 13篇 |
1991年 | 10篇 |
1990年 | 19篇 |
1989年 | 28篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 23篇 |
1985年 | 20篇 |
1984年 | 13篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 4篇 |
1980年 | 10篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 13篇 |
1975年 | 9篇 |
排序方式: 共有1919条查询结果,搜索用时 15 毫秒
1.
The effect of substance P and other tachykinins on inositol phospholipid hydrolysis in rabbit retina, superior colliculus and retinal cultures 总被引:1,自引:0,他引:1
Substance P and eledoisin stimulate the accumulation of inositol phosphates in a dose-dependent manner in retinal and superior colliculus slices of the rabbit. The EC50 values for substance P and eledoisin in both tissues were of the same order (1.5-4.9 microM), suggesting that the receptors in the two tissues were alike with characteristics of the SP-P subtype rather than the SP-E subtype. These data suggest that the SP-immunoreactive material in the retinal ganglion and amacrine cells is identical. The effectiveness for a number of tachykinin substances at 10(-5) M for stimulating inositol phosphates accumulation was as follows: Substance P greater than eledoisin greater than neurokinin A greater than neurokinin B greater than substance P (octapeptide) greater than substance P (pentapeptide). Spantide [(D-Arg1, D-Try7.9, Leu11) substance P] and (D-Pro2, D-Try7.9) substance P did not stimulate inositol phospholipid hydrolysis. However, spantide, at a concentration of 10(-6) M, was an antagonist of the effect produced by substance P, but had no action on the effect produced by neurokinin A or neurokinin B. Substance P and other tachykinins were also effective in stimulating inositol phosphates accumulation in 3-5-day-old rabbit retinal cultures but did not elicit a response in the older (25-30-day-old) cultures which lacked neurones but contained Müller cells. Furthermore, substance P was only active in the younger cultures in stimulating an increase in internal calcium levels. It is therefore concluded that retinal tachykinin receptors linked to phosphoinositide turnover and calcium mobilisation are associated exclusively with neurones and not with Müller cells. 相似文献
2.
Trigger finger is uncommon among children and often caused by various lesions. We report a 5-year old girl who presented with chronic painless triggering of the right ring finger and normal X-ray. She underwent exploration of the finger flexor tendons and release of the A1 pulley. Lack of obvious pathology dictated further wound exploration which revealed a hidden osteochondroma of the proximal phalanx. We believe that adequate surgical wound exposure is necessary if no obvious cause of triggering could be seen in order to rule out an atypical osteochondroma even in the presence of normal X-rays. 相似文献
3.
4.
5.
Calciphylaxis – a topical overview 总被引:3,自引:0,他引:3
G Arseculeratne† AT Evans‡ SM Morley† 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):493-502
'Calciphylaxis', a calcification syndrome associated with ischaemic cutaneous necrosis, is acquired naturally in humans in disease states. It is a life and limb-threatening complication, usually observed in patients with renal disease and secondary hyperparathyroidism, but known to occur in the absence of renal or parathyroid disease. The reported mortality rate, which ranges from 60-80%, relates to wound infection, sepsis and organ failure. It is a small-vessel vasculopathy, which is estimated to occur in about 4% of haemodialysis patients. Clinically, violaceous, reticulate areas of cutaneous necrosis and eschar may be evident, particularly in the extremities. In addition to the clinical picture, a raised calcium phosphorous product, an elevated parathyroid hormone level, radiographic evidence of vessel and soft-tissue calcification and the finding of mural calcification affecting small arteries and arterioles on histopathology help to confirm the diagnosis of this entity which generally has a poor prognosis. A high index of suspicion and an active multidisciplinary management approach, with rigorous attention to wound care and prevention of sepsis, are vital in the management of these patients. In this overview, we discuss the pathophysiology, clinical features and associations, risk factors, diagnosis and management issues relating to calciphylaxis. 相似文献
6.
Bastiaan R Klarenbeek Alexander AFA Veenhof Elly SM de Lange Willem A Bemelman Roberto Bergamaschi Piet Heres Antonio M Lacy Wim T van den Broek Donald L van der Peet Miguel A Cuesta 《BMC surgery》2007,7(1):16
Backround
Diverticulosis is a common disease in the western society with an incidence of 33–66%. 10–25% of these patients will develop diverticulitis. In order to prevent a high-risk acute operation it is advised to perform elective sigmoid resection after two episodes of diverticulitis in the elderly patient or after one episode in the younger (< 50 years) patient. Open sigmoid resection is still the gold standard, but laparoscopic colon resections seem to have certain advantages over open procedures. On the other hand, a double blind investigation has never been performed. The Sigma-trial is designed to evaluate the presumed advantages of laparoscopic over open sigmoid resections in patients with symptomatic diverticulitis. 相似文献7.
8.
9.
10.