全文获取类型
收费全文 | 9026篇 |
免费 | 540篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 206篇 |
妇产科学 | 249篇 |
基础医学 | 1273篇 |
口腔科学 | 195篇 |
临床医学 | 950篇 |
内科学 | 2100篇 |
皮肤病学 | 89篇 |
神经病学 | 758篇 |
特种医学 | 298篇 |
外科学 | 1112篇 |
综合类 | 111篇 |
一般理论 | 13篇 |
预防医学 | 708篇 |
眼科学 | 176篇 |
药学 | 692篇 |
中国医学 | 5篇 |
肿瘤学 | 584篇 |
出版年
2023年 | 53篇 |
2022年 | 78篇 |
2021年 | 164篇 |
2020年 | 136篇 |
2019年 | 157篇 |
2018年 | 173篇 |
2017年 | 136篇 |
2016年 | 115篇 |
2015年 | 209篇 |
2014年 | 260篇 |
2013年 | 421篇 |
2012年 | 656篇 |
2011年 | 671篇 |
2010年 | 348篇 |
2009年 | 307篇 |
2008年 | 578篇 |
2007年 | 650篇 |
2006年 | 627篇 |
2005年 | 604篇 |
2004年 | 576篇 |
2003年 | 521篇 |
2002年 | 561篇 |
2001年 | 85篇 |
2000年 | 83篇 |
1999年 | 112篇 |
1998年 | 109篇 |
1997年 | 97篇 |
1996年 | 85篇 |
1995年 | 88篇 |
1994年 | 67篇 |
1993年 | 64篇 |
1992年 | 62篇 |
1991年 | 71篇 |
1990年 | 51篇 |
1989年 | 46篇 |
1988年 | 41篇 |
1987年 | 37篇 |
1986年 | 43篇 |
1985年 | 36篇 |
1984年 | 39篇 |
1983年 | 28篇 |
1982年 | 57篇 |
1981年 | 28篇 |
1980年 | 26篇 |
1979年 | 27篇 |
1978年 | 25篇 |
1977年 | 31篇 |
1976年 | 15篇 |
1975年 | 25篇 |
1973年 | 21篇 |
排序方式: 共有9607条查询结果,搜索用时 15 毫秒
1.
Steven V Koenen Anjoke J M Huisjes Jules Dings Yolanda van der Graaf Gerard H A Visser Hein W Bruinse 《The journal of maternal-fetal & neonatal medicine》2006,19(2):93-99
OBJECTIVE: To determine if there is a diurnal pattern in the clinical symptoms of HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) syndrome. STUDY DESIGN: A retrospective study was performed in 134 pregnancies complicated by HELLP syndrome. The medical records were reviewed to describe each HELLP episode. Time of day was divided into three periods, day, evening, and night. The following parameters were categorized according to the time of day: onset of symptoms, consultation by the doctor, initial blood sampling, diagnosis and decrease of symptoms. Biochemical parameters at clinical presentation and consecutive changes within 24 h were recorded. RESULTS: In 65 pregnancies 77 HELLP episodes were well documented. Times of onset of symptoms and consultation by the doctor were significantly higher during the evening and night (p < 0.001), whereas times of diagnosis and decrease of symptoms occurred significantly more during the day (p < 0.001). In only 49.3% of the cases were diagnostic laboratory criteria met at clinical presentation. This was mainly due to platelet values in excess of 100 x 10(9)/l. Several hours later (median 8 h, range 2-23) the decrease in platelets occurred. CONCLUSIONS: A diurnal pattern exists in the clinical symptoms of HELLP syndrome that is characterized by an exacerbation during the night and recovery during the day. There is a considerable delay between the onset of symptoms and the fulfillment of diagnostic laboratory criteria. 相似文献
2.
3.
4.
Gerard J Molloy Derek W Johnston Chuan Gao Miles D Witham Joan M Gray Ishbel S Argo Allan D Struthers Marion E T McMurdo 《European journal of cardiovascular prevention and rehabilitation》2006,13(3):381-387
BACKGROUND: The impact of exercise programmes for heart failure on those close to the patient is largely unknown. We examined the effect of a hospital and home-based exercise intervention on burden, anxiety and depression of informal caregivers. DESIGN: The study was a randomized, controlled trial. Heart failure patients were randomized to a seated 12-week hospital-based exercise programme. Caregiver measures were gathered at baseline, 3 months later and 6 months following baseline. METHODS: Sixty caregivers (mean age 63.4 years, 65% female) of heart failure patients (n = 82, mean age 80.5 years, 44% female) participating in a trial of an exercise intervention were recruited. Caregiver burden, anxiety and depression were assessed. RESULTS: There were no differences in caregiver burden, depression or anxiety between the two groups of caregivers at baseline (caregiver burden, patient control 33.1 versus patient exercise 34.1; anxiety 4.1 versus 5.5; depression 2.8 versus 3.8). At 3 months there were no differences between caregivers in the two groups on outcomes. At 6-month follow-up caregivers of heart failure patients in the exercise group had burden scores that were significantly worse than the control group. There were no differences between the carers of exercise and control groups in anxiety and depression. Levels of anxiety and depression in the entire carer sample were marginally higher than reference values in a healthy non-clinical sample. CONCLUSION: The present exercise interventions for frail older patients did not benefit caregivers and was associated with an increase in caregiver burden. We suggest that future exercise interventions for heart failure patients should actively incorporate informal caregivers into research designs. 相似文献
5.
Described in 1981 by the Chinese authors Yang Kuofan et al. [1] as a free flap, then in 1982 by Lu et al. [2] as a retrograde
flow pedicle flap, this fasciocutaneous flap is designed at the level of the anterior and external faces of the forearm, and
vascularized by the radial artery via a network of septal arteries. Prior to utilization it must be reversed on its distal
pedicle. This flap allows repairing cutaneous substance loss of the whole hand and fingers. The emergence of the Chinese flap
in the 1980’s resulted in a regression of the Mac Gregor groin flap that was widely used at this time [3,4]. Nevertheless,
other forearm flaps, less “expensive” in terms of vascular involvement [5–9] have reduced its indications. The Chinese flap
however keeps two essential indications: the multi-finger important defect that no other forearmflapmay cover; and composite
substance loss of the thumb (despite the fact that the Chinese flap shares these indications with interosseous artery composite
flaps). 相似文献
6.
Tass H Malik Iain A Bruce Gerard Kelly Richard T Ramsden Shakeel R Saeed 《Skull base》2007,17(4):235-238
In cases of cerebrospinal fluid (CSF) rhinorrhea following lateral skull base surgery, fibrosis and fibrin formation resulting from meningitis has been postulated as a mechanism of spontaneously resolving the CSF leak. This study was undertaken to explore any possible relationship between the cessation of CSF leak and meningitis. A retrospective study at a tertiary referral center of 232 consecutive patients was performed. Out of a total of 232 procedures, 29 patients developed CSF rhinorrhea, of whom 7 subsequently developed meningitis. Bacteria were isolated in CSF obtained at lumbar puncture in 5 cases, with the CSF analysis in the remaining 2 cases suggesting aseptic meningitis. Conservative treatment failed to stop the CSF rhinorrhea in 6 of 7 cases. In this study, the development of meningitis did not appear to aid in the resolution of the CSF rhinorrhea. We conclude that surgical intervention should not be delayed in the expectation that meningitis and conservative interventions may promote CSF leak resolution. 相似文献
7.
8.
Mario Sénéchal Isabelle Lemieux Isabel Beucler Gerard Drobinski Sylvie Cormont Michelle Dubois Iradj Gandjbakhch Jean-Pierre Després Richard Dorent 《The Journal of heart and lung transplantation》2005,24(7):819-826
BACKGROUND: This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD). METHODS: In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28%) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles. RESULTS: Seventy-seven per cent of patients with waist circumference values >/= 90 cm and with elevated triglyceride levels (>/=2.0 mmol/liter) were characterized by this atherogenic metabolic triad. Patients with the atherogenic metabolic triad were at markedly increased risk of CAD (odds ratio of 25.3, 95% CI: 1.11-577.3, p < 0.04) compared to heart transplant patients without the atherogenic metabolic triad. CONCLUSIONS: About 30% of heart transplant patients showed the features of the atherogenic metabolic triad. Measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles. The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population. 相似文献
9.
Dexmedetomidine and Cardiac Arrest 总被引:2,自引:0,他引:2
10.
Susanne Binder Mireille Bonnet Michaela Velikay Jean-Pierre Gerard Ulrike Stolba Andreas Wedrich Hannelore Hohenberg 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1994,232(4):211-214
In a prospective study of the effect of postoperative radiation therapy for the prevention of reproliferation of membranes and recurrent proliferative vitreoretinopathy (PVR) two similar groups of patients with retinal detachment and PVR grade D1 to D3 in one eye were compared. Half the eyes (30) received a total dose of 3000 cGy after surgery; the other half remained untreated. After a followup of 6 months and 14 months or more (maximum 36 months) the anatomical and functional results of each group were compared. After 6 months in the unirradiated group 57% (17/30) remained attached and 43% (13/30) had detached again. In the irradiated group 63% (19/30) were attached and 37% (11/30) had detached. However, there was no statistically significant difference between the two groups (P=0.479, Fisher's Exact Test). After 14 months the number of cured and uncured eyes remained the same in the unirradiated group, while in four of the eyes in the irradiated group a later onset of reproliferation and detachment occurred (after 7, 8, 12 and 14 months, respectively). A final cure rate of 57% (17/30) was achieved in the unirradiated group and a 50% (15/30) cure rate in the irradiated group. Thus the failure rate was 43% (13/30) in the unirradiated group and 50% (15/30) in the irradiated group (P=0.473, Fisher's Exact Test). No side effects from the radiation were observed in any case and no radiation retinopathy occurred during an observation period of up to 3 years. The visual acuity of the cured treated and cured untreated eyes was similar in the two groups. From these results we conclude that immediate radiation treatment does not improve the long-term results and does not reduce the number of reoperations. In a considerable number of treated eyes the onset of reproliferation was delayed from 7 to 14 months, whereas in the untreated group reproliferation was always observed during the first 6 months. A combination of various antiproliferative and antiinflammatory therapies are needed to suppress recurrent PVR after succesful vitreoretinal surgery and to minimize the side effects of these treatments.Presented in part at the XVIIth Meeting of the Club Jules Gonin, 1–6 September 1990, Lausanne 相似文献