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排序方式: 共有190条查询结果,搜索用时 15 毫秒
1.
Maya Koronyo-Hamaoui Eva Gak Daniel Stein Amos Frisch Yardena Danziger Shani Leor Elena Michaelovsky Neil Laufer Cynthia Carel Silvana Fennig Marc Mimouni Alan Apter Boleslav Goldman Gad Barkai Abraham Weizman 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2004,(1):76-80
The human small-conductance Ca(2+)-activated potassium channel gene KCNN3 has been involved in mechanisms underlying neuronal function and plasticity. A multiallelic CAG repeat polymorphism within the KCNN3 has been associated with schizophrenia and bipolar disorder. We have previously reported in a family-based study that longer CAG repeats are preferentially transmitted to patients with anorexia nervosa (AN). The present study extends the analysis of KCNN3 allele distribution to a larger series of AN female patients and control groups, incorporating information on ethnicity and co-morbidities associated with AN. The data analysis is presented while considering separately the two alleles of each individual, namely a minor (shorter) and a major (longer) allele. This study has found that the KCNN3 allele distribution in the general Israeli population does not differ significantly in at least four Jewish ethnic groups of Ashkenazi, North African, Iraqi, and Yemenite origin. These have been used as control groups in a matched case-control analysis that has demonstrated a significant over-representation of KCNN3 alleles with longer CAG repeats among AN patients (P < 0.001 for the major allele and P = 0.035 for allele sum). Under dichotomization, a significantly higher prevalence of the L allele (>19 repeats) has been observed among AN patients (P < 0.001). While considering AN and co-morbid phenotypes, a tendency towards longer (L) alleles has been observed in the subset of patients with obsessive-compulsive disorder (OCD) co-morbidity. These findings further implicate KCNN3 as a significant contributor to predisposition to AN. 相似文献
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Kidong Kim Suhyun Hwangbo Hyojin Kim Yong Beom Kim Jae Hong No Dong Hoon Suh Taesung Park 《Journal Of Gynecologic Oncology》2022,33(3)
ObjectiveThe need to perform genetic sequencing to diagnose the polymerase epsilon exonuclease (POLE) subtype of endometrial cancer (EC) hinders the adoption of molecular classification. We investigated clinicopathologic and protein markers that distinguish the POLE from the copy number (CN)-low subtype in EC.MethodsNinety-one samples (15 POLE, 76 CN-low) were selected from The Cancer Genome Atlas EC dataset. Clinicopathologic and normalized reverse phase protein array expression data were analyzed for associations with the subtypes. A logistic model including selected markers was constructed by stepwise selection using area under the curve (AUC) from 5-fold cross-validation (CV). The selected markers were validated using immunohistochemistry (IHC) in a separate cohort.ResultsBody mass index (BMI) and tumor grade were significantly associated with the POLE subtype. With BMI and tumor grade as covariates, 5 proteins were associated with the EC subtypes. The stepwise selection method identified BMI, cyclin B1, caspase 8, and X-box binding protein 1 (XBP1) as markers distinguishing the POLE from the CN-low subtype. The mean of CV AUC, sensitivity, specificity, and balanced accuracy of the selected model were 0.97, 0.91, 0.87, and 0.89, respectively. IHC validation showed that cyclin B1 expression was significantly higher in the POLE than in the CN-low subtype and receiver operating characteristic curve of cyclin B1 expression in IHC revealed AUC of 0.683.ConclusionBMI and expression of cyclin B1, caspase 8, and XBP1 are candidate markers distinguishing the POLE from the CN-low subtype. Cyclin B1 IHC may replace POLE sequencing in molecular classification of EC. 相似文献
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Rapid radiometric methods to detect and differentiate Mycobacterium tuberculosis/M. bovis from other mycobacterial species 总被引:13,自引:0,他引:13
S H Siddiqi C C Hwangbo V Silcox R C Good D E Snider G Middlebrook 《The American review of respiratory disease》1984,130(4):634-640
Rapid methods for the differentiation of Mycobacterium tuberculosis/M. bovis (TB complex) from other mycobacteria (MOTT bacilli) were developed and evaluated in a three-phase study. In the first phase, techniques for identification of Mycobacterium species were developed by using radiometric technology and BACTEC Middlebrook 7H12 liquid medium. Based on 14CO2 evolution, characteristic growth patterns were established for 13 commonly encountered mycobacterial species. Mycobacteria belonging to the TB complex were differentiated from other mycobacteria by cellular morphology and rate of 14CO2 evolution. For further differentiation, radiometric tests for niacin production and inhibition by Q-nitro-alpha-acetyl amino-beta-hydroxy-propiophenone (NAP) were developed. In the second phase, 100 coded specimens on Lowenstein-Jensen medium were identified as members of the TB complex, MOTT bacilli, bacteria other than mycobacteria, or "no viable organisms" within 3 to 12 (average 6.4) days of receipt from the Centers for Disease Control. Isolation and identification of mycobacteria from 20 simulated sputum specimens were carried out in phase III. Out of 20 sputum specimens, 16 contained culturable mycobacteria, and all of the positives were detected by the BACTEC method in an average of 7.3 days. The positive mycobacterial cultures were isolated and identified as TB complex or MOTT bacilli in an average of 12.8 days. The radiometric NAP test was found to be highly sensitive and specific for a rapid identification of TB complex, whereas the radiometric niacin test was found to have some inherent problems. Radiometric BACTEC and conventional methodologies were in complete agreement in Phase II as well as in Phase III. 相似文献
6.
Gak Hwangbo Chae-Woo Lee Seong-Gil Kim Hyeon-Su Kim 《Journal of Physical Therapy Science》2015,27(4):1153-1155
[Purpose] The aim of this study was to examine the effect of trunk stability exercise and
combined exercise program on pain, flexibility, and static balance in chronic low back
pain patients. [Subjects and Methods] Thirty persons diagnosed with chronic low back pain
were divided into a trunk stability exercise group and a combined exercise group and then
conducted exercise for six weeks. [Results] VAS and sway lengths decreased significantly
in both groups. A comparison of sway lengths after the intervention between the two groups
revealed that the trunk stability exercise group had a bigger decrease than the combined
exercise group. [Conclusion] The results of this study indicated that trunk stability
exercise would have bigger effect than combined exercise on the daily activities of
chronic low back pain patients as it strengthens deep abdominal muscles and improves
flexibility and balancing ability.Key words: Low back pain, Balance, Trunk stability exercise 相似文献
7.
[Purpose] The purpose of the study was to investigate the effects of action observation
training on the static balance and walking ability of patients who had suffered a stroke.
[Subjects] Forty patients with hemiplegia resulting from a stroke were divided into an
action observation gait training group (AOGT group, n=20) and a general gait training
group (GGT group, n=20). [Methods] The AOGT group watched a training video on flatland
gait, slope gait, and stair gait. The GGT group watched a video on nature. Both groups
watched their respective video for 10 minutes and then had gait training for 20 minutes
per day, five times per week, for eight weeks. [Results] The static balance and gait
ability of both groups significantly improved. Although there were significant differences
between the groups, the AOTG group showed greater improvements in sway speed, limit of
stability, and gait ability. [Conclusion] We recommend action observation training over
general gait training for patients with hemiplegia. Action observational training had a
positive effect on static balance and gait ability in stroke patients’ static balance and
gait ability. Further research is needed to generalize the results of this study.Key words: Hemiplegia, Action observation training, Gait 相似文献
8.
Dongjun Jeong PhD Yujun Jeong MS Ji Hye Park MD Sun Wook Han MD Sung Yong Kim MD PhD Yeo Joo Kim MD PhD Sang Jin Kim MD PhD Young Hwangbo MD PhD Soyoung Park MS Hyun Deuk Cho MD PhD Mee Hye Oh MD PhD Seung Ha Yang MD PhD Chang Jin Kim MD PhD 《Annals of surgical oncology》2013,20(3):759-766
Background
Activating somatic mutation of the BRAF V600E has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87 %) in different series by different methods. The BRAF V600E mutation is associated with various clinicopathological parameters. The mutation is an important factor for the management of the PTC patients. The objective of this study was to detect the BRAF V600E mutation in PTCs by peptide nucleic acid (PNA) clamp real-time PCR and to analyze the results with clinicopathological parameters.Methods
We performed genetic analysis of BRAF V600E by PNA clamp real-time PCR in 211 PTCs in Korea, stratified by clinicopathological parameters.Results
The BRAF V600E mutation was detected in 90 % of PTC cases, and it occurred significantly more often in female patients than in male patients (p = 0.001). The clinicopathological parameters of age, tumor size, and disease stage were not associated with the BRAF V600E mutation, while extrathyroid invasion (p = 0.031), lymph nodal metastasis (p = 0.002), and tumor multiplicity (p = 0.020) were.Conclusions
The prevalence (90 %) of the BRAF V600E mutation in this study is the highest ever reported, confirming the key role of this mutation in PTC tumorigenesis. The BRAF V600E mutation was associated with aggressive clinical behaviors including extrathyroid invasion, lymph nodal metastasis and tumor multifocality. The PNA clamp real-time PCR method for the BRAF V600E mutation detection is sensitive and is applicable in a clinical setting. 相似文献9.
Hyo Hyun Yang Kyoung Hwangbo Ming Shan Zheng Jung Hee Cho Jong-Keun Son Hwa Young Kim Suk Hwan Baek Hyung Chul Choi So Young Park Jae-Ryong Kim 《Archives of pharmacal research》2014,37(9):1219-1233
Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as age-related disease. In this study, we investigated compounds from Polygonum aviculare to determine if they inhibited cellular senescence in human primary cells, human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Ten compounds from P. aviculare were purified and their inhibitory effects on adriamycin-induced cellular senescence were measured by observing senescence-associated β-galactosidase (SA-β-gal) activity and reactive oxygen species. Among them, compound 9 (quercetin-3-O-β-d-glucuronide) showed inhibitory effects against cellular senescence in HDFs and HUVECs treated with adriamycin. Additionally, compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 represses cellular senescence in human primary cells and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or aging-associated diseases. 相似文献
10.
Arking R Novoseltseva J Hwangbo DS Novoseltsev V Lane M 《The journals of gerontology. Series A, Biological sciences and medical sciences》2002,57(11):B390-B398
We review the empirical data obtained with our normal-lived Ra control strain of Drosophila and show that this one genome is capable of invoking at least three different responses to external stimuli that induce the animal to express one of three different extended longevity phenotypes, each of which arises from one of three different antagonistic molecular mechanisms of stress resistance. The phenotypes are distinguished by different age-specific mortality patterns. Depending on the selected mechanism, the genome may respond by expressing a delayed onset of senescence (type 1), an increased early survival (type 2), or an increased late survival (type 3) phenotype, suggesting their different demographic effects. We suggest that the different demographic effects stem in part from the differential ability of each selection regime to reallocate the organism's energy from reproduction to somatic maintenance. These data document the complexity of the aging process and argue for a relationship between molecular mechanisms and longevity phenotypes. 相似文献