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排序方式: 共有82条查询结果,搜索用时 357 毫秒
1.
Prognostic Implications of Defibrillation Threshold Testing in Patients With Hypertrophic Cardiomyopathy 下载免费PDF全文
2.
FABIO PIZZA KEIVAN K. MOGHADAM STEFANO VANDI STEFANIA DETTO FRANCESCA POLI EMMANUEL MIGNOT RAFFAELE FERRI GIUSEPPE PLAZZI 《Journal of sleep research》2013,22(1):32-40
In the diagnostic work‐up of hypersomnias of central origin, the complaint of excessive daytime sleepiness should be objectively confirmed by MSLT findings. Indeed, the features and diagnostic utility of spontaneous daytime sleep at 24 h continuous polysomnography (PSG) have never been investigated. We compared daytime PSG features to MSLT data in 98 consecutive patients presenting with excessive daytime sleepiness and with a final diagnosis of narcolepsy with cataplexy/hypocretin deficiency (n = 39), narcolepsy without cataplexy (n = 7), idiopathic hypersomnia without long sleep time (n = 19), and ‘hypersomnia’ with normal sleep latency at MSLT (n = 33). Daytime sleep time was significantly higher in narcolepsy‐cataplexy but similar in the other groups. Receiver operating characteristics (ROC) curves showed that the number of naps during daytime PSG predicted a mean sleep latency ≤8 min at MSLT with an area under the curve of 0.67 ± 0.05 (P = 0.005). The number of daytime sleep‐onset REM periods (SOREMPs) in spontaneous naps strikingly predicted the scheduled occurrence of two or more SOREMPs at MSLT, with an area under the ROC curve of 0.93 ± 0.03 (P < 10?12). One spontaneous SOREMP during daytime had a sensitivity of 96% with specificity of 74%, whereas two SOREMPs had a sensitivity of 75%, with a specificity of 95% for a pathological REM sleep propensity at MSLT. The features of spontaneous daytime sleep well correlated with MSLT findings. Notably, the occurrence of multiple spontaneous SOREMPs during daytime clearly identified patients with narcolepsy, as well as during the MSLT. 相似文献
3.
MARCO SCAGLIONE M.D. DOMENICO CAPONI M.D. MATTEO ANSELMINO M.D. Ph.D. FRANCESCA DI CLEMENTE M.D. ALESSANDRO BLANDINO M.D. FEDERICO FERRARIS M.D. PAOLO DI DONNA M.D. ELISA EBRILLE M.D. FRANCK HALIMI M.D. JEAN F. LECLERCQ M.D. COSTANZA IUNCO M.D. CARLOEUGENIO VAUDAGNA M.D. FEDERICO CESARANI M.D. FIORENZO GAITA M.D. 《Journal of cardiovascular electrophysiology》2014,25(12):1299-1305
4.
FRANCESCA LUNDSTR
M-ROCHE 《British Journal of Learning Disabilities》1982,10(1):29-30
Over the past few years there has been a growing awareness of the sexual needs of mentally handicapped people (Craft and Craft, 1978). In many instances programmes of sex education have been set up for them. But has society in general come to any kind of acceptance of the sexual needs of the mentally handicapped, or even the fact that these people are men and women? 相似文献
5.
M. BODDI F. BARBANI† R. ABBATE‡ M. BONIZZOLI† S. BATACCHI† E. LUCENTE M. CHIOSTRI G. F. GENSINI A. PERIS† 《Journal of thrombosis and haemostasis》2010,8(1):121-128
Summary. Background : Deep vein thrombosis (DVT) is a major complication in intensive care units (ICU) but dedicated guidelines on its management are still lacking. Objectives and Methods : This study investigated the effect of a 1-year educational program for the implementation of DVT prophylaxis on the incidence of inferior limb DVT in a mixed-bed ICU that admits high-risk surgical and trauma patients, investigated during a first retrospective phase [126 patients, SAPS II score 42 (28–54)] and a following prospective phase [264 patients, SAPS II score II 41 (27–55)]. The role of baseline and time-dependent DVT risk factors in DVT occurrence was also investigated during the prospective phase. Results : The educational program on implementation of DVT prophylaxis was associated with a significant decrease in DVT incidence from 11.9% to 4.5% ( P < 0.01) and in the mean length of ICU stay ( P < 0.01). Combined with pharmacological prophylaxis, the use of elastic compressive stockings significantly also increased in the prospective phase ( P < 0.01). The duration of mechanical ventilation, vasopressor administration and neuromuscular block were significantly different between DVT-positive and DVT-negative patients ( P < 0.01). Multivariate analysis identified neuromuscular block as the strongest independent predictor for DVT incidence. Conclusion : One-year ICU-based educational programs on implementation of DVT prophylaxis were associated with a significant decrease in the incidence of DVT and also in the length of stay in ICU. 相似文献
6.
JOSEP L. TORRES FRANCESCA REIG GREGORIO VALENCIA RAQUEL E. RODRÍGUEZ JOS M. GARCÍA-ANT
N 《Chemical biology & drug design》1988,31(5):474-480
Different synthetic strategies have been attempted for the synthesis of a glycosylpeptide resulting from the covalent bonding of a sugar residue to the C-terminal carboxyl group of an enkephalin related pentapeptide. The final structure is: Tyr-d -Met-Gly-Phe-Pro [N15-β-d -glucopyranosyl] amide. The in vitro potency on the GPI test of this analogue was IC50= 64.0 nm . However, its antinociceptive activity by tail immersion tests, after intraperitoneal administration, was 2000 and 200 times higher than morphine in rats and mice, respectively. 相似文献
7.
ANTONIO MICHELUCCI LUIGI PADELETTI REA CHELUCCI ALESSANDRO MEZZANI MARIA C. PORCIANI FEDERICO CARUSO EMANUELE LEBRUN FRANCESCA BACCI MOIRA MARTELLI GIAN FRANCO GENSINI 《Pacing and clinical electrophysiology : PACE》1996,19(5):758-767
Signal-averaged P wave of 42 patients with lone paroxysmal atrial fibrillation (PAF) and 29 normal subjects (N) were recorded, using three orthogonal leads and analyzed in the time and frequency (entire P wave or a 100-ms segment ranging from 75 ms before to 25 ms after the end of P wave) domains. PAFs were divided into a group of 12 having ≥ 2 attacks a month (HF) and a group of 30 having ≤ 2 attacks a year (LF). Statistically significant differences were absent with regard to ages of PAF and N; ages of HF, LF, and N at the time of signal-averaged ECG; ages of HF and LF at the time of the first arrhythmic episode; and elapsed times from the first episode. Length of P wave and some frequency-domain parameters were found to be significantly correlated with age. PAF showed a significantly longer duration of P wave in the frontal plane using the time-domain analysis. Frequency analysis was found to be useful in evaluating the influence of attack frequency. HF showed significantly higher values of some frequency-domain parameters than LF and N, while the three groups did not differ for time-domain analysis. P wave duration and frequency content of the three orthogonal leads proved to be significantly different in PAF and N. Right and left atrial echocardiographic dimensions proved to be higher (even if within normal limits) in HF than in LF and N. Results suggest that frequency analysis should be performed on the entire P wave. 相似文献
8.
ANDREW BOTTOMLEY phd CHANTAL QUINTEN msc CORNEEL COENS msc FRANCESCA MARTINELLI msc MURIELLE MAUER phd JOHN MARINGWA phd CHARLES S. CLEELAND phd HENNING FLECHTNER phd CAROLYN GOTAY phd EVA GREIMEL phd MADELEINE KING phd DAVID OSOBA md MARTIN J.B. TAPHOORN phd BRYCE B. REEVE phd JOLIE RINGASH phd JOSEPH SCHMUCKER-VON KOCH phd & JOACHIM WEIS phd 《European journal of cancer care》2009,18(2):105-107
9.
Impact of a Chronic Total Occlusion in an Infarct‐Related Artery on the Long‐Term Outcome of Ventricular Tachycardia Ablation 下载免费PDF全文
ANDREA DI MARCO M.D. GABRIELE PAGLINO M.D. TERESA OLORIZ M.D. GIUSEPPE MACCABELLI M.D. FRANCESCA BARATTO M.D. PASQUALE VERGARA M.D. Ph.D. CATERINA BISCEGLIA M.D. Ph.D. IGNASI ANGUERA M.D. Ph.D. SIMONE SALA M.D. NICOLETA SORA M.D. PAOLO DALLAGLIO M.D. ALESSANDRA MARZI M.D. NICOLA TREVISI M.D. PATRIZIO MAZZONE M.D. PAOLO DELLA BELLA M.D. 《Journal of cardiovascular electrophysiology》2015,26(5):532-539
10.
ETTORE BISMUTO GIOVANNI COLONNA FRANCESCA SAVY GAETANO IRACE 《Chemical biology & drug design》1985,26(2):195-207
The effects of heme removal on the molecular structure of tuna and sperm whale myoglobin have been investigated by comparing the solvent accessibility to the heme pocket of the two proteins with that of the corresponding apoproteins. Although the heme microenvironment of tuna myoglobin is more polar than that of sperm whale myoglobin, the accessibility of solvent to heme is identical in the two proteins as revealed by thermal perturbation of Soret absorption. The removal of heme produces loss of helical folding and increase of solvent accessibility but the effects are rather different for the two proteins. More precisely, the loss of helical structure upon heme removal is 50% for tuna myoglobin and 15% for sperm whale myoglobin; moreover, the solvent accessibility of the heme pocket of tuna apomyoglobin is 2–3-fold greater than that of sperm whale apomyoglobin. These results have been explained in terms of the lack of helical folding in segment D, the structural organization of which may have a relevant effect in regulating the accessibility of ligands to the heme. The effects produced by charged quenchers reveal that the ligand path from the surface of the molecule to the ion atom of the heme involves a positively charged residue which may reasonably be identified as Arg-45 (sperm whale myoglobin) or Lys-41 (tuna myoglobin) on the basis of recent X-ray crystallographic information. 相似文献