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Yulia Lin Everad Tilokee Sophie Charg Asim Alam Christine Cserti‐Gazdewich Wendy Lau Christie Lee Lani Lieberman Paula Nixon Wendy Owens Katerina Pavenski Jacob Pendergrast Elianna Saidenberg Nadine Shehata Robert Skeate Qi‐Long Yi David Conrad Jill Dudebout Cyrus C. Hsia Michael Murphy Oksana Prokopchuk‐Gauk Akshay Shah Ziad Solh Jacqueline Trudeau Michelle P. Zeller Jeannie Callum 《Transfusion》2019,59(6):2141-2149
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Despite advances in treatment, heart failure remains one of the top killers in Canada. This recognition motivated a new research focus to harness the fundamental repair properties of the human heart. Since then, cardiac stem cells (CSCs) have emerged as a promising cell candidate to regenerate damaged hearts. The rationale of this approach is simple with ex vivo amplification of CSCs from clinical-grade biopsies, followed by delivery to areas of injury, where they engraft and regenerate the heart. In this review we will summarize recent advances and discuss future developments in CSC-mediated cardiac repair to treat the growing number of Canadians living with and dying from heart failure. 相似文献
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