全文获取类型
收费全文 | 267150篇 |
免费 | 8742篇 |
国内免费 | 4633篇 |
专业分类
耳鼻咽喉 | 2177篇 |
儿科学 | 7850篇 |
妇产科学 | 3991篇 |
基础医学 | 28238篇 |
口腔科学 | 3258篇 |
临床医学 | 22420篇 |
内科学 | 45125篇 |
皮肤病学 | 2259篇 |
神经病学 | 21838篇 |
特种医学 | 13224篇 |
外国民族医学 | 21篇 |
外科学 | 38729篇 |
综合类 | 14367篇 |
现状与发展 | 28篇 |
一般理论 | 43篇 |
预防医学 | 24336篇 |
眼科学 | 5235篇 |
药学 | 18963篇 |
67篇 | |
中国医学 | 4543篇 |
肿瘤学 | 23813篇 |
出版年
2024年 | 207篇 |
2023年 | 1075篇 |
2022年 | 2643篇 |
2021年 | 3851篇 |
2020年 | 2762篇 |
2019年 | 2704篇 |
2018年 | 24497篇 |
2017年 | 19749篇 |
2016年 | 22072篇 |
2015年 | 4972篇 |
2014年 | 5953篇 |
2013年 | 6079篇 |
2012年 | 14609篇 |
2011年 | 28903篇 |
2010年 | 23841篇 |
2009年 | 15920篇 |
2008年 | 25194篇 |
2007年 | 27166篇 |
2006年 | 5908篇 |
2005年 | 6965篇 |
2004年 | 7109篇 |
2003年 | 7951篇 |
2002年 | 5667篇 |
2001年 | 2049篇 |
2000年 | 1868篇 |
1999年 | 1509篇 |
1998年 | 1124篇 |
1997年 | 1043篇 |
1996年 | 808篇 |
1995年 | 737篇 |
1994年 | 715篇 |
1993年 | 505篇 |
1992年 | 487篇 |
1991年 | 488篇 |
1990年 | 473篇 |
1989年 | 386篇 |
1988年 | 268篇 |
1987年 | 268篇 |
1986年 | 215篇 |
1985年 | 182篇 |
1984年 | 123篇 |
1983年 | 120篇 |
1982年 | 128篇 |
1981年 | 96篇 |
1980年 | 130篇 |
1978年 | 54篇 |
1977年 | 50篇 |
1974年 | 57篇 |
1938年 | 63篇 |
1932年 | 58篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Kei Kamide Yoshihiro Kokubo Hironori Hanada Junko Nagura Jin Yang Shin Takiuchi Chihiro Tanaka Mariko Banno Yoshikazu Miwa Masayoshi Yoshii Tetsutaro Matayoshi Hisayo Yasuda Takeshi Horio Akira Okayama Hitonobu Tomoike Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(4):243-252
Mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2, HSD11B2, cause a rare monogenic juvenile hypertensive syndrome called apparent mineralocorticoid excess (AME). In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension. Here, we have studied whether genetic variations in HDS11B2 are implicated in essential hypertension in Japanese hypertensives and the general population. By sequencing the entire coding region and the promoter region of HDS11B2 in 953 Japanese hypertensives, we identified five missense mutations in 11 patients (L14F, n = 5; R74H, n = 1; R147H, n = 3; T156I, n = 1; R335H, n = 1) and one novel frameshift mutation (4884Gdel, n = 1) in a heterozygous state, in addition to 19 genetic variations. All genetic variations identified were rare, with minor allele frequencies less than 0.005. Four of 12 patients with the missense/frameshift mutations showed renal failure. Four missense mutations, L14F, R74H, R147H, and R335H, were successfully genotyped in the general population, with a sample size of 3,655 individuals (2,175 normotensives and 1,480 hypertensives). Mutations L14F, R74H, R147H, and R335H were identified in hypertensives (n = 6, 8, 3, and 0, respectively) and normotensives (n = 8, 12, 5, and 0, respectively) with a similar frequency, suggesting that these missense mutations may not strongly affect the etiology of essential hypertension. Since the allele frequency of all of the genetic variations identified in this study was rare, an association study was not conducted. Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese. 相似文献
2.
3.
Jin Sik Burm 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(3):253-256
This paper describes the use of a composite graft from the mastoid area consisting of full-thickness skin peripherally and selectively localised fascia-fat tissue underneath the skin centrally for immediate reconstruction of moderate defects of the nasal tip including the columella and soft triangle. Mastoid composite grafting is a simple and safe procedure that avoids partial graft loss and provides adequate augmentation of soft tissue, easy reshaping of the new nostril rim, minimal post-operative shrinkage, and no donor-site morbidity. Then, it results in a satisfactory nasal appearance with adequate tip projection and symmetry. This procedure may represent a preferred method of nasal tip reconstruction. 相似文献
4.
5.
6.
Susanne Ramsauer 《Zeitschrift für Psychodrama und Soziometrie》2007,6(2):293-302
Anliegen dieses Artikels ist, die besondere Qualit?t und Chance von Psychodramatischer Supervision zu beschreiben, und gleichzeitig
die Kompatibilit?t und fruchtbare Erg?nzung des Moreno’schen Ansatzes innerhalb des Formats Supervision innerhalb der Sozialen
Arbeit auf zuzeigen. Dies wird anhand von 2 ausgew?hlten Praxisbeispielen dargestellt. Die Handlungskompetenz von Supervisandinnen
und Supervisanden kann durch einfache psychodramatische Interventionen erweitert werden. Handlungshemmung wird überwunden,
Spontaneit?t und Kreativit?t kommen ins Laufen und er?ffnen Perspektiven. 相似文献
7.
8.
Debra L. Roter Richard M. Frankel Judith A. Hall David Sluyter 《Journal of general internal medicine》2006,21(1):28-34
Relationship-centered care reflects both knowing and feeling: the knowledge that physician and patient bring from their respective domains of expertise, and the physician’s and patient’s experience, expression, and perception of emotions during the medical encounter. These processes are conveyed and reciprocated in the care process through verbal and nonverbal communication. We suggest that the emotional context of care is especially related to nonverbal communication and that emotion-related communication skills, including sending and receiving nonverbal messages and emotional self-awareness, are critical elements of high-quality care. Although nonverbal behavior has received far less study than other care processes, the current review argues that it holds significance for the therapeutic relationship and influences important outcomes including satisfaction, adherence, and clinical outcomes of care. 相似文献
9.
10.