Die Pharmakologie des herzwirksamen Stoffes der Mistel

Naunyn-Schmiedeberg's Archives of Pharmacology -     

A Chinese adolescent girl with Fechtner-like syndrome

We describe a 15-y-old girl with Fechtner-like syndrome, who is the first Chinese reported to have this rare syndrome. She presented with left homonymous hemianopia and neuroimaging revealed haemorrhage in both parietal and occipital lobes. Peripheral blood smear showed macrothrombocytopenia and intracytoplasmic inclusion bodies inside leucocytes. Thrombocytopenia and proteinuria responded to intravenous immunoglobulin and pulsed methylprednisolone. This case illustrates that life-threatening haemorrhage can occur in patients with Fechtner syndrome. Although there was no effective treatment reported in the literature, high dose steroid and immunoglobulin seemed to be useful in our patient. Our patient also had nephritic-nephrotic syndrome with renal insufficiency, which is unusual in adolescent female patients.     

Gastroesophageal Reflux,Motility Disorders,and Psychological Profiles in the Etiology of Globus Pharyngis

The aim of this study was to investigate the origin of globus pharyngis with particular reference to esophageal disorders such as gastroesophageal reflux disease (GERD), motility disorders, structural abnormalities, other gastrointestinal tract diseases, and psychological profile. Previous studies on this subject using 24-hour pH monitoring give conflicting results and are hampered by the high background prevalence of asymptomatic GERD in the normal Western population. The local Chinese population is known to have a very low background level of GERD and therefore is an ideal study population. Twenty-six patients with globus pharyngis underwent 24-hour ambulatory pH monitoring, esophageal manometry, and esophagogas-troduodenoscopy with lower esophageal biopsy. A control group of 20 patients presenting with non-ulcer dyspepsia was similarly investigated. Personality profiles of the globus pharyngis subjects and an appropriate control group were assessed. Eight of the globus pharyngis group (30.7%) had evidence of GERD, whereas only one of the controls (5%) demonstrated GERD on 24-hour esophageal pH monitoring (P < 0.05). The manometric and personality profile studies did not show significant differences between study and control groups. We concluded that the finding of GERD in patients with globus pharyngis is not a coincidental finding but that there is a true association between GERD and globus pharyngis.     

Changes of immunoglobulin concentrations in the bile after proximal gastric vagotomy in rats

We have investigated the influence of proximal gastric vagotomy in rats (PGV) on the immunoglobulin concentration in the serum, bile, and intestinal fluid. Clear differences for serum IgA were noted: after PGV, rats had 1.5 mg/ml IgA in contrast to only 0.25 mg/ml in sham-operated controls. The other serum immunoglobulins remained unchanged. Bile immunoglobulins were elevated in PGV rats with regard to IgA, IgG1, IgG2a, and IgG2b. In addition, PGV rats had higher IgA, IgG1, IgG2a, and IgG2b concentrations in the intestinal fluid than controls. An explanation for these high Ig concentrations in the secretions might be the challenge by intestinal (microbial) antigens and, perhaps, mucosal inflammation with changes in the permeability. Indications for the former were the increase in the number of bacteria after PGV.     

Le Infezioni Perinatali

Le infezioni microbiche possono mettere a rischio la gravidanza e/o la salute del bambino. Esse possono provocare aumento delia morbilitÀ F. dar luogo, a seconda del momento della gestazione in cui si verificano, ad infezione del prodotto del concepimento, ad aborto, a nascita di un nato morto, a malformazioni, ad alterazioni dello sviluppo, a malattie neonatali e ad infezioni croniche dal decorso variabile.     

THE PROLONGED COEXISTENCE OF VACCINIA VIRUS IN HIGH TITRE AND LIVING CELLS IN ROLLER TUBE CULTURES OF CHICK EMBRYONIC TISSUES

1. The virus of vaccinia in so called roller tube cultures of mixed embryonic chick tissue rapidly increases to maximal titre. 2. Under these conditions the quantity of virus in the tissue remains at or near the maximum for at least 9 weeks and considerable amounts are present in the fluids removed each day. 3. The same results are obtained when only fragments of embryonic chick heart are employed. 4. Many, though not necessarily all, of the cells in infected cultures remain alive and retain the capacity to proliferate. The presence of these living cells is essential for the persistence of the virus. 5. No apparent differences in the rate or amount of growth of cells in infected as contrasted with non-infected cultures can be discerned in the gross. 6. It is suggested, but not proved, that virus is continually being produced rather than simply preserved throughout the period.