全文获取类型
收费全文 | 2296篇 |
免费 | 135篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 216篇 |
妇产科学 | 25篇 |
基础医学 | 235篇 |
口腔科学 | 59篇 |
临床医学 | 208篇 |
内科学 | 431篇 |
皮肤病学 | 76篇 |
神经病学 | 130篇 |
特种医学 | 492篇 |
外科学 | 207篇 |
综合类 | 41篇 |
预防医学 | 83篇 |
眼科学 | 26篇 |
药学 | 85篇 |
中国医学 | 4篇 |
肿瘤学 | 131篇 |
出版年
2022年 | 7篇 |
2021年 | 14篇 |
2020年 | 16篇 |
2019年 | 18篇 |
2018年 | 31篇 |
2017年 | 24篇 |
2016年 | 42篇 |
2015年 | 42篇 |
2014年 | 42篇 |
2013年 | 92篇 |
2012年 | 57篇 |
2011年 | 53篇 |
2010年 | 98篇 |
2009年 | 74篇 |
2008年 | 69篇 |
2007年 | 67篇 |
2006年 | 52篇 |
2005年 | 52篇 |
2004年 | 41篇 |
2003年 | 35篇 |
2002年 | 43篇 |
2001年 | 32篇 |
2000年 | 44篇 |
1999年 | 45篇 |
1998年 | 136篇 |
1997年 | 125篇 |
1996年 | 127篇 |
1995年 | 95篇 |
1994年 | 78篇 |
1993年 | 81篇 |
1992年 | 28篇 |
1991年 | 29篇 |
1990年 | 26篇 |
1989年 | 71篇 |
1988年 | 59篇 |
1987年 | 60篇 |
1986年 | 57篇 |
1985年 | 57篇 |
1984年 | 33篇 |
1983年 | 39篇 |
1982年 | 40篇 |
1981年 | 25篇 |
1980年 | 43篇 |
1979年 | 20篇 |
1978年 | 18篇 |
1977年 | 22篇 |
1976年 | 26篇 |
1975年 | 31篇 |
1973年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有2453条查询结果,搜索用时 421 毫秒
1.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
2.
I. Kaare Tesdal Werner Jaschke Mathias Bühler Ralf Adamus Thomas Filser Eggert Holm Max Georgi 《Cardiovascular and interventional radiology》1997,20(1):29-37
Purpose To evaluate prospectively our experience with transjugular intrahepatic portosystemic shunt (TIPS) using four different metallic
stents.
Methods Between November 1991 and April 1995, 57 patients (41 men and 16 women; age 35–72 years, mean 54 years) underwent the TIPS
procedure. Techniques for portal vein localization before and during TIPS were fluoroscopy, computed tomography (CT) studies,
wedged hepatic venography, arterial portography, and ultrasound. After predilation we deployed balloon-expandable (n=48) and self-expanding (n=45) metallic stents. Fifteen patients underwent variceal embolization. Initial follow-up angiograms (mean 6.9 months, range
3–24 months) were obtained in 39 of these patients.
Results Fifty-three patients (93%) had successful TIPS placement. The mean decrease in portal pressure was 42.7%. Besides fluoroscopy,
the most helpful techniques for portal vein localization were venography and CT. Residual stenosis (n=1) and late shortening (n=4) of Wallstents resulted in shunt dysfunction. The technical problems encountered with the Palmaz stent resulted from its
lack of flexibility. We combined balloon-expandable and self-expanding stents in 12 patients. The 30-day and late follow-up
(mean 11.9 months) percutaneous reintervention rates were 11.3% and 64.2%, respectively. There were no clinically significant
complications related to the TIPS insertions.
Conclusion An ideal stent does not exist for TIPS, and the authors recommend combining a Palmaz stent with a flexible self-expanding
stent. 相似文献
3.
4.
5.
6.
7.
8.
9.
10.
P Ll Sigurdsson Tryggvi Thorvaldsson Sveinbj
Rn Gizurarson Eggert Gunnarsson 《Drug delivery》1997,4(3):195-200
A vast number of potent neuropharmaceuticals, many of which are peptides, are excluded from entry into the brain because of the highly selective blood-brain barrier. The fact that a number of drugs have been shown to be transported directly to the central nervous system following application to the olfactory region of the nose is therefore of major interest. In the present study, the feasibility of delivering peptides to the brain via the olfactory route was assessed using insulin as a model peptide. Systemic hyperinsulinemia induced by subcutaneous injection did not significantly reduce the amount of 125I-insulin transported from the nose to the brain in vivo, which suggests that the impact of systemic absorption on drug transport is minimal. A linear relationship was seen between insulin accumulation in the brain and the dose applied, without any relevant saturation. Contrary to what was expected, both systemic and olfactory absorption of insulin was enhanced when the pH of the medium was near the isoelectric point. The amount absorbed to the brain was found to be linearly related to the net charge of the molecule (r = -0.61; n = 20). It was concluded that insulin gains access to the central nervous system from the olfactory region of the nose by a nonspecific pathway. The olfactory route may therefore become an important means to deliver peptides to the brain. 相似文献